Translational stroke research

01 20 October 2026

DOI 10.1007/s12975-026-01507-9

Integrated Transcriptomic and Single-Cell Sequencing Identifies Altered Expression of Circadian Rhythm-Related Genes Pomc and Bmp4 in Post-Stroke Depression

Open DOI

Yuntai Wang, Jing Li, Yihuan Yuan et al.

02 13 October 2026

DOI 10.1007/s12975-026-01502-0

Acute Ischaemic Stroke: Therapeutic Targets and Key Modulators of the Fibrinolytic System and Clot Formation

Open DOI

Oshi Swarup, Anna H. Balabanski, Geoffrey C. Cloud et al.

The processes of clot formation and clot dissolution with fibrinolysis underpin the pathophysiological mechanisms of acute ischaemic stroke (AIS) and its treatment. Detailed understanding of the modulation of this system is required to d...

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03 13 October 2026

DOI 10.1007/s12975-026-01497-8

Long-Term Quantitative MRI and Quality-of-Life After Endovascular Therapy in Acute Ischemic Stroke – A MR CLEAN-NO IV Substudy

Open DOI

Praneeta R. Konduri, Dimitrios Karkalousos, Alexandra de Sitter et al.

This study aims to explore the long-term evolution of endovascular treatment after acute ischemic stroke (AIS) using quantitative MRI, and its relationship with quality of life (QoL). In this long-term substudy of patients from the MR CL...

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04 8 October 2026

DOI 10.1007/s12975-026-01499-6

Lipid Traits and Risk of Subarachnoid Haemorrhage: A Systematic Review and Mendelian Randomization Study in UK Biobank

Open DOI

Frederick Ewbank, Cameron Pinn, Benjamin Gaastra et al.

Lipid traits are established risk factors for atherosclerotic disease; however, their relationship with intracranial aneurysms and subarachnoid haemorrhage (SAH) remains unclear. Recent Mendelian randomisation (MR) studies have reported ...

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05 3 October 2026

DOI 10.1007/s12975-026-01500-2

Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Cognitive Outcome after Stroke: A Systematic Review

Open DOI

Prach Uthayo, Marc Feldman, Natalie Olivares

06 2 October 2026

DOI 10.1007/s12975-026-01498-7

Chemokine CXCL10 and Incident Stroke Risk in the Northern Manhattan Study

Open DOI

Mohammad Nafeli Shahrestani, Christian Agudelo, Hannah Gardener et al.

Inflammation contributes to cerebrovascular disease, but prospective studies of broad immune marker panels and incident stroke are limited. We aimed to identify plasma immune markers independently associated with incident stroke. Stroke-...

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07 25 September 2026

DOI 10.1007/s12975-026-01495-w

Exogenous Hydrogen Sulfide Donors Suppress Neointimal Hyperplasia by Modulating Mitochondrial Dysfunction in Vascular Smooth Muscle Cells

Open DOI

Yanyan He, Chenqing Li, Bing Zhang et al.

08 23 September 2026

DOI 10.1007/s12975-026-01496-9

Effect Modification of Rescue Stenting in ICAS-Related Middle Cerebral Artery Occlusion: The Role of Thrombectomy Failure, Stenosis Severity, and ASPECTS

Open DOI

Andrea M. Alexandre, Luca Scarcia, Adam A. Dmytriw et al.

Rescue stenting (RS) is increasingly used for intracranial artery stenosis-related large vessel occlusion (ICAS-LVO), but optimal patient selection remains uncertain. We investigated the baseline and procedural factors associated with re...

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09 28 August 2026

DOI 10.1007/s12975-026-01490-1

Thrombin Generation Capacity is Associated With Worse Outcome in r-tPA Treated Patients With Stroke

Open DOI

Sarina Falcione, Twinkle Joy, Danielle Munsterman et al.

10 27 August 2026

DOI 10.1007/s12975-026-01494-x

Salvaging the No-Reflow Zone: Intra-arterial Cranial Bone-Derived MSCs Restore Neurovascular Integrity After Stroke

Open DOI

Takeshi Hara, Masaaki Takeda, Masashi Kuwabara et al.

Successful macrovascular recanalization does not always translate into functional recovery, in part because early post-reperfusion injury can drive infarct expansion. Here, we investigated whether hyperacute intra-arterial transplantatio...

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