Thrombosis and haemostasis

01 14 October 2026

DOI 10.1055/a-2979-5643

Small interfering RNA targeting protein Z-dependent protease inhibitor improves hemostasis in Von Willebrand factor- and Factor X-deficient mice

Open DOI

Rim Hamze, Mariem Khamari, Kaitlyn R Calabro et al.

Non-factor therapeutics have transformed the treatment paradigm in hemophilia A. Owing to their mode of action, these agents may also provide benefit for other rare bleeding disorders (RBDs) such as von Willebrand disease (VWD)-type 3 an...

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02 13 October 2026

DOI 10.1055/a-2980-6716

Antithrombotic Therapy in Coronary Embolism: A Multicenter Study

Open DOI

Alberto Vera, Eva Jover, Jeanne Varlot et al.

Background Coronary embolism (CE) is an uncommon cause of acute myocardial infarction, and the optimal post-discharge antithrombotic strategy remains uncertain. Methods Retrospective multicenter study including patients with definite or ...

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03 8 October 2026

DOI 10.1055/a-2977-5555

Estimates, temporal evolution, and contributors of the stroke burden due to air pollution and non-optimal temperature across G20 nations, 1990–2023

Open DOI

Renfang Zhang, Fei Lin, Yongbin Wang

Background: Air pollution and non-optimal temperature are major modifiable environmental risk factors for stroke. This study assessed their attributable stroke burden across G20 countries from 1990 to 2023 and projected trends to 2040. M...

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04 8 October 2026

DOI 10.1055/a-2969-4582

Associations of Triglyceride Glucose Index-related Obesity Indices, Genetic Susceptibility, and the Risk of Venous Thromboembolism: Insights from a Prospective Cohort Study

Open DOI

Yuyang Sun, Jun Deng, Xi Cao et al.

The triglyceride glucose (TyG) index and related obesity metrics are commonly recognized as important indicators of insulin resistance. However, the associations of several novel TyG-related obesity indices developed with venous thromboe...

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05 6 October 2026

DOI 10.1055/a-2972-1645

ML Models for early and accurate prediction of disseminated intravascular coagulation: The diagnosis of DIC depends on the diagnostic tool.

Open DOI

Hideo Wada

06 30 September 2026

DOI 10.1055/a-2958-5047

Design Update for Refining Validated Tools for Pulmonary Embolism Identification in Electronic Databases: The PE-EHR+ Extension Study

Open DOI

Julia Malejczyk, Sina Rashedi, Christopher Amalan et al.

07 28 September 2026

DOI 10.1055/a-2939-4076

Machine Learning Models for Suspected Pulmonary Embolism in Emergency Department Patients: A Multicentre Diagnostic Study

Open DOI

Christophe A. Fehlmann, Ben Meuleman, Helia Robert-Ebadi et al.

Pulmonary embolism (PE) is frequently suspected in emergency departments (EDs). Safely ruling out PE without additional testing could reduce imaging use and ED crowding. Machine learning (ML) may improve accuracy and efficiency. To evalu...

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08 23 September 2026

DOI 10.1055/a-2954-8993

Ticagrelor vs. Clopidogrel in ACS Patients Underwent PCI: An Analysis Based on Systemic Immune-inflammation Risk Stratification

Open DOI

Hengbo Zhai, Miaohan Qiu, Kun Na et al.

The systemic immune-inflammation index (SII) is an established prognostic marker in coronary artery disease. This study investigated the association between SII and 1-year prognosis in patients with acute coronary syndrome (ACS) undergoi...

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09 22 September 2026

DOI 10.1055/a-2963-4851

VLDL Subfractions and Risk of Future Venous Thromboembolism— The HUNT Study

Open DOI

Inga Aalberg Røstvold, Ben Michael Brumpton, Kristian Hveem et al.

In vitro studies have suggested prothrombotic properties of very low-density lipoproteins (VLDL). Whether differences in VLDL particle size and lipid composition are related to venous thromboembolism (VTE) risk has been scarcely investig...

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10 22 September 2026

DOI 10.1055/a-2963-4595

Val325Met Mutation Affects N-glycosylation and Impairs the Function of Protein C

Open DOI

Shijie Zhou, Junwei Yuan, Xi Wu et al.

Protein C (PC) is a key anticoagulant protein that regulates hemostatic balance. Hereditary PC deficiency increases the risk of thrombosis. We identified the same mutation, c.1099G > A:p.V325 M (V325 M), in the PROC gene in four unrelate...

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