The Journal of antimicrobial chemotherapy

01 6 October 2026

DOI 10.1093/jac/dkag333

Benzylpenicillin exposure during veno-venous extracorporeal membrane oxygenation: pre- and post-oxygenator levels in a case report

Open DOI

Lieke van Gastel, Eva van Haren, Tim Smeets et al.

02 6 October 2026

DOI 10.1093/jac/dkag344

Sitagliptin attenuates urease-associated phenotypes and potentiates meropenem in multidrug-resistant Gram-negative clinical isolates: a preliminary repurposing study

Open DOI

Afaf Eladl, Hisham A Abbas, Marwa Ibrahim Abd El-Hamid et al.

Background: Urease contributes to urinary tract pathogenesis and catheter encrustation, whereas metallo-β-lactamases contribute to carbapenem resistance. Objectives: We investigated whether the dipeptidyl peptidase-4 inhibitor sitaglipti...

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03 6 October 2026

DOI 10.1093/jac/dkag346

Genomic evidence of clonal and IncX3 plasmid-mediated dissemination of bla NDM-7 in the Klebsiella pneumoniae complex

Open DOI

Yujing Zhang, Guqi Ren, Jing Wu et al.

Background: Carbapenem-resistant Enterobacterales (CRE), particularly those carrying New Delhi metallo-β-lactamase (NDM) variants, pose a major global health threat. Among these, NDM-7 has attracted increasing attention due to its enhanc...

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04 6 October 2026

DOI 10.1093/jac/dkag345

Direct measurement of eravacycline effluent concentrations during continuous venovenous haemodiafiltration: negligible clearance in a critically ill patient

Open DOI

Guanghui Chen, Qiang Qu, Yanyan Zhou et al.

05 6 October 2026

DOI 10.1093/jac/dkag342

Determinants of levofloxacin prophylaxis failure in high-risk haematology patients: a prospective study integrating resistant colonization and pharmacokinetic/pharmacodynamic target attainment—authors’ response

Open DOI

Cemre Boşnak, Gökhan Metan, Pınar Zarakolu et al.

06 6 October 2026

DOI 10.1093/jac/dkag339

Phylogenetic diversification of the PoxtA ribosomal protection determinant

Open DOI

Lara M Almeida, Felipe M Zorzi, Kawany M Araujo et al.

Objectives: Three ATP-binding cassette subfamily F (ABC-F) PoxtA protein sequences are currently represented in NCBI’s Pathogen Detection Reference Gene Catalog (WP_002415638.1, WP_209691075.1, and WP_094899500.1), while the number of pu...

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07 6 October 2026

DOI 10.1093/jac/dkag323

Oxazolidinones in the Clinical Management of Staphylococcal Infection—Linezolid or Tedizolid? A review on behalf of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Staphylococci and Staphylococcal Diseases (ESGS)

Open DOI

Liana Macpherson, Anne-Grete Martson, Jose L Del Pozo et al.

There is limited information in the existing literature regarding the choice of oxazolidinone in clinical practice to treat infections caused by staphylococcal species. As members of the European Society of Clinical Microbiology and Infe...

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08 6 October 2026

DOI 10.1093/jac/dkag341

Comment on: Determinants of levofloxacin prophylaxis failure in high-risk haematology patients: a prospective study integrating resistant colonization and pharmacokinetic/pharmacodynamic target attainment

Open DOI

Basavaraj Poojar

09 6 October 2026

DOI 10.1093/jac/dkag338

Intergeneric mobilization of a genomic island mediated by a helper integrative conjugative element from Streptococcus suis to Enterococcus faecalis

Open DOI

Kaiwei Nie, Jiaqi Zhao, Cai Yin et al.

Background and objectives: Mobile genetic elements drive antimicrobial-resistance dissemination in Gram-positive pathogens. In Streptococcus suis we previously identified a genomic island, GISsuJHJ17_rpsI, integrated at the conserved rps...

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10 6 October 2026

DOI 10.1093/jac/dkag337

Tigecycline displays bactericidal activity against multidrug-resistant Neisseria gonorrhoeae and enhances clearance from a mouse infection model

Open DOI

Xia Sun, Wenyan Lu, Haoyu Ge et al.

Objectives: The global emergence of ceftriaxone-resistant Neisseria gonorrhoeae threatens current first-line treatment and necessitates alternative therapeutic options. Tigecycline, a last-line glycylcycline antibiotic approved for compl...

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