The Journal of antibiotics

01 19 October 2026

DOI 10.1038/s41429-026-00965-5

Correction: Amino acid mapping–guided scaffold selection and hit identification of histidine kinase inhibitors from a virtual library of over 12 million compounds

Open DOI

Teruhiko Ishikawa, Yoko Eguchi, Toshihide Okajima et al.

02 9 October 2026

DOI 10.1038/s41429-026-00963-7

In vitro activity and comparative efficacy of novel nitrofuran-containing ciprofloxacin analogs against bacterial pathogens including ciprofloxacin-resistant Staphylococcus aureus

Open DOI

Kate Marshall, Patricia A. Miller, Reilly M. Coates et al.

The rapid rise of antimicrobial resistance, especially in Staphylococcus aureus , highlights the urgent need for improved antibacterial agents. In 2019 alone, AMR caused an estimated 1.27 million deaths and contributed to nearly 5 millio...

Read abstract

03 9 October 2026

DOI 10.1038/s41429-026-00962-8

Inhibition of vasculogenic mimicry by 22-benzyloxydaphlongaminone via glycolysis suppression

Open DOI

Yuma Tanaka, Akari Murase, Makoto Muroi et al.

Vasculogenic mimicry (VM) is a phenomenon in which tumor cells themselves form vascular-like tubular structures within the tumor. Identification of novel VM inhibitors is an important research subject in tumor biology. In this study, we ...

Read abstract

04 30 September 2026

DOI 10.1038/s41429-026-00953-9

Amino acid mapping–guided scaffold selection and hit identification of histidine kinase inhibitors from a virtual library of over 12 million compounds

Open DOI

Teruhiko Ishikawa, Yoko Eguchi, Toshihide Okajima et al.

Waldiomycin is a natural product originally isolated from actinomycete extracts. It inhibits histidine kinases (HKs), which are essential components of bacterial two-component signal transduction systems, by targeting the conserved H-box...

Read abstract

05 28 September 2026

DOI 10.1038/s41429-026-00961-9

P450 cyptide synthase KwwB catalyzes non-native cross-link at Tyr-C3–Trp-N1 and tolerates leader peptide mutations

Open DOI

Gaja Swarna Kumari, Abujunaid Habib Khan, Jabal Rahmat Haedar et al.

Cyptides refer to a rapidly growing class of ribosomally synthesized and post-translationally modified peptides (RiPPs) containing biaryl cyclophanes installed by P450 enzymes. Here, we further investigated P450 cyptide synthase KwwB fro...

Read abstract

06 14 September 2026

DOI 10.1038/s41429-026-00958-4

New anti-fungal compounds 1PB1 and 45R from Streptomyces chrestomyceticus ADP4 target exo-β-1,3-glucanase and ergosterol biosynthesis in Candida albicans

Open DOI

Jyoti Shukla, Ashok K. Dubey

07 2 September 2026

DOI 10.1038/s41429-026-00957-5

CSA-13 treatment in a murine model of Pseudomonas pneumonia-induced sepsis and its effects on renal injury, inflammation, and glycocalyx derangement

Open DOI

Ugur Aksu, Cagla Bozkurt-Guzel, Gonca Erkose-Genc et al.

08 24 August 2026

DOI 10.1038/s41429-026-00954-8

“Lariocidin and ribosome-targeting lasso peptides as emerging antimicrobial agents against multidrug-resistant bacteria”

Open DOI

Ahmed Mahdy, Khaled M. Alam-ElDein, Ismail Amin et al.

Lasso peptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) with mechanically constrained structures that provide high stability and target selectivity. Among them, lariocidin (LAR), produced by Paenibac...

Read abstract

09 21 August 2026

DOI 10.1038/s41429-026-00955-7

Taxonomic characterization of Kribbella broussonetiae sp. nov., a novel rare actinomycete isolated from the rhizosphere soil of Broussonetia papyrifera

Open DOI

Ming-Yue Li, Yan Xiao, Jian Gao

A novel rare actinomycete strain, WER1T, was isolated from rhizosphere soil of Broussonetia papyrifera collected from Xiangtan City, Hunan province, China. Strain WER1T contained ll-diaminopimelic acid as the diagnostic diamino acid in t...

Read abstract

10 21 August 2026

DOI 10.1038/s41429-026-00956-6

Two new diastereomeric sterigmatocystin derivatives from the culture broth of Hypomyces sp.

Open DOI

Yongkuk Lee, Dae-Cheol Choi, Dae-Won Ki et al.

Two new sterigmatocystin derivatives, named hyposterigmatocystin A and B (1 and 2), and three known compounds, 3a,12c-dihydro-8,12c-dihydroxy-6-methoxy-7H-furo[3′,2′:4,5]furo[2,3-c]xanthen-7-one (3), sterigmatocystin (4), and secosterigm...

Read abstract