Science translational medicine

01 14 October 2026

DOI 10.1126/scitranslmed.aem8786

Editorial Expression of Concern for the Research Article “In vivo CRISPR activation screen identifies acyl-CoA–binding protein as a driver of bone metastasis”

Open DOI

Valda Vinson, Orla Smith

02 14 October 2026

DOI 10.1126/scitranslmed.aem5154

Retraction of the Research Article “SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies”

Open DOI

Valda Vinson, Orla Smith

On 27 July 2022, Science Translational Medicine published the Research Article “SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies” by K. W. Ng et al. (1). After an investigation, the Francis Crick Institute has c...

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03 14 October 2026

DOI 10.1126/scitranslmed.aeh1292

Orthogonal Fc engineering enables multiplexed delivery of mRNA-encoded bispecific antibodies that constrain viral escape

Open DOI

Anna Z. Wec, Alice Cho, Simone Pecetta et al.

The continuous antigenic evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has repeatedly undermined the effectiveness of monoclonal antibody (mAb) therapies, underscoring the need for innovative approaches that i...

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04 14 October 2026

DOI 10.1126/scitranslmed.aeg5988

Rifampicin-resistant TB: An inflection point in antimicrobial resistance

Open DOI

Cesar Augusto Roque-Borda, João Perdigão, Fernando Rogério Pavan

Rifampicin-resistant TB should be integrated into the global AMR response through diagnostics, surveillance, and optimized treatment regimens.

05 14 October 2026

DOI 10.1126/scitranslmed.aef8416

Innovative roadmaps for sustainable antimicrobial resistance interventions

Open DOI

Gianmarco Gasperini, Silvia Rossi Paccani, Karen O’DWyer et al.

Integrated strategies to combat antibiotic-resistant bacteria and fungi require innovative commercial models, new discovery platforms, standardized genomic surveillance, and streamlined clinical trials. Machine learning and other new tec...

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06 14 October 2026

DOI 10.1126/scitranslmed.aee4629

From code to cure: Harnessing AI for antibiotic discovery and design

Open DOI

Aarti Krishnan, Hanqun Cao, James J. Collins et al.

Artificial intelligence (AI) now enables the exploration of vast chemical and sequence spaces, the design of synthesizable antibiotics, and the prioritization of safe, mechanism-diverse candidates through integrated modeling and accelera...

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07 14 October 2026

DOI 10.1126/scitranslmed.aec9689

Quinolinic acid contributes to maladaptive kidney injury and acute kidney injury–to–chronic kidney disease transition

Open DOI

Marie Christelle Saade, Afaf Saliba, Amanda J. Clark et al.

The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) remains a major clinical problem with unclear underlying mechanisms. Emerging evidence suggests that alterations in tryptophan metabolism, particularly in the ...

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08 14 October 2026

DOI 10.1126/scitranslmed.aec5740

Preclinical and first-in-human evaluation of VG-3927/SAR448851, an oral small-molecule TREM2 agonist for Alzheimer’s disease

Open DOI

Borislav Dejanovic, Matthew D. Figley, Elizabeth Weisman et al.

Microglial dysfunction is increasingly implicated in Alzheimer’s disease (AD) pathogenesis, with loss-of-function variants in the microglial receptor TREM2 as major risk factors for late-onset AD. We report VG-3927, an oral, CNS-penetran...

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09 14 October 2026

DOI 10.1126/scitranslmed.adz4815

Metabolomic aging and mortality clocks based on ensemble learning identify systemic aging risk across the human life span in 18,476 individuals

Open DOI

Linlin Cao, Yifan Chen, Wei Zhang et al.

Aging is characterized by progressive functional decline, yet metabolomic signatures across the human life span remain incompletely defined. Here, we profiled plasma metabolomes from 18,476 participants aged 1 to 96 years across six cent...

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10 14 October 2026

DOI 10.1126/scitranslmed.ady4852

Restoration of PP2A AαB56αC trimer formation by RPT04402 molecular glue in high-grade uterine cancer

Open DOI

Irene Peris, Terrance J. Haanen, Alexander Day et al.

The incidence and mortality of high-grade endometrial cancers are increasing, and heterozygous hotspot mutations in PPP2R1A are drivers of the most aggressive forms of uterine cancer. PPP2R1A encodes the Aα scaffolding subunit of the het...

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