Protein & cell

01 10 October 2026

DOI 10.1093/procel/pwag068

Correction: Postnatal state transition of cardiomyocyte as a primary step in heart maturation

Open DOI

02 1 October 2026

DOI 10.1093/procel/pwag073

Mosaic Loss of the Y Chromosome: Mechanisms and Diseases

Open DOI

Qi Zhang, Jiang Yu, Xiaoqian Zhai et al.

Mosaic loss of the Y chromosome (mLOY) is a male‑specific somatic loss of the Y chromosome that is predominantly observed in peripheral blood leukocytes, but can also be found in other tissue types. It represents one of the most common m...

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03 30 September 2026

DOI 10.1093/procel/pwag071

Human intestinal organoid models: Advancing Inflammatory Bowel Disease Research

Open DOI

Haifang Wang, Yandong Chen, Hui Liu et al.

The incidence of inflammatory bowel disease (IBD), which affects the health of millions of people worldwide, is increasing. The etiology and pathogenesis of IBD are complex, and well-established in vitro models that closely mimic disease...

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04 23 September 2026

DOI 10.1093/procel/pwag072

NDRG2 orchestrates structural and functional adaptation for cardioprotection during mammalian hibernation

Open DOI

Ning Guo, Haijian Sun, Yan Wei et al.

Cold stress severely challenges the cardiovascular system under distinct physiological contexts: environmental cold exposure, systemic hypothermia, and donor heart cold preservation. Yet, hibernating mammals remarkably tolerate these ext...

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05 15 September 2026

DOI 10.1093/procel/pwag069

An H2A.Z-dependent epigenetic checkpoint in macrophages couples genetic risk to microbial metabolite signaling

Open DOI

Zhaoran Sun, Fanyi Meng, Chunjian Piao et al.

Inflammatory gene programs must be precisely controlled to maintain immune homeostasis, yet the chromatin mechanisms enforcing transcriptional shutdown remain unclear. Here we show that the histone variant H2A.Z is evicted from pro-infla...

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06 15 September 2026

DOI 10.1093/procel/pwag070

Evolution of debate on the human adult hippocampal neurogenesis

Open DOI

Biyu Yang, Kun Cui, Jiuyang Ding et al.

07 8 September 2026

DOI 10.1093/procel/pwag064

The lifelong transcriptomic landscape of human blood cells

Open DOI

Xiaowei Xie, Lianshuo Li, Fang Hong et al.

Single-cell technologies have transformed our view of normal and malignant hematopoiesis, yet a framework linking lifelong homeostatic hematopoiesis to hematological diseases in blood ecosystem remains incomplete. Here, we constructed a ...

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08 4 September 2026

DOI 10.1093/procel/pwag067

Indole-3-propionic acid is an endogenic agonist of hypoxia-inducible factor-1α to protect the heart against hypoxia

Open DOI

Ziang Zhang, Sen Yu, Yuan Xing et al.

Tryptophan catabolism by the gut microbiota is increasingly recognized as a hub connecting environmental challenges to cardiovascular health. By systematically profiling tryptophan metabolites in humans who had moved from low altitude to...

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09 4 September 2026

DOI 10.1093/procel/pwag066

A Dual role of alveolar macrophage in driving host defense and pulmonary immunopathology during hypervirulent Acinetobacter baumannii pneumonia

Open DOI

Duo Su, Yan Wang, Lu Li et al.

Hypervirulent Acinetobacter baumannii (hvAB) is a leading cause of refractory bacterial pneumonia. However, cellular and molecular mechanisms underlying hvAB-induced host protection and pulmonary immunopathology remain poorly understood....

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10 3 September 2026

DOI 10.1093/procel/pwag065

Guanine promotes acute lung injury by repressing H3K27me3 in sepsis

Open DOI

Chao-Qun Wang, Hui-Juan Wang, Yue-Yu Kong et al.

Sepsis is systemic inflammation with high mortality, accompanied by multi-organ failure including acute respiratory distress syndrome. Extracellular vesicles (EVs) encapsulating bioactive cargoes, mediate cell-cell communication to exert...

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