Physiological research

01 31 August 2026

DOI 10.33549/physiolres.935799

Trichostatin A Inhibits Cytokines Released in LPS-Induced THP-1 Cells via Downregulating Deacetylated-Syntaxin 17 and Promoting Autophagosome-Lysosome Fusion

Open DOI

Le Sang, Ran Zang, Zewei Yu et al.

Sepsis is a complicated disorder caused by infection, which may trigger various symptoms. Lipopolysaccharides (LPS) are among the primary pathogens which can stimulate host’s immunoreaction. In the late stage of sepsis, the patients’ imm...

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02 31 August 2026

DOI 10.33549/physiolres.935851

Hydrogen Sulfide Suppresses RANKL-Induced Osteoclast Differentiation by Modulating Nrf2/GPX4 Signaling

Open DOI

Zelin Huang, Ming Lai, Qinglan Wei et al.

Excessive osteoclast activity drives bone-resorptive disorders, and oxidative stress is a key regulator of osteoclast differentiation. Hydrogen sulfide (H₂S), an endogenous antioxidant, may modulate this process, but its mechanisms remai...

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03 31 August 2026

DOI 10.33549/physiolres.935744

Electrical Impedance Tomography-Guided Synergistic Intervention of Respiratory Muscle Training and Postural Adjustment for Lung Recruitment in Critically Ill Patients With Respiratory Failure

Open DOI

Hongfei Wang, Zhu Lin, Hongmei Gao

Lung collapse and ventilation heterogeneity are common in mechanically ventilated critically ill patients. Electrical impedance tomography (EIT) enables real-time bedside monitoring of regional ventilation and may facilitate individualiz...

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04 31 August 2026

DOI 10.33549/physiolres.935737

Peripubertal Exposure to Silver Nanoparticles (AgNPs) Triggers Follicle Activation, Probably Leading to “Burnout” by Stimulating the PI3K/AKT/mTOR/AMPK Signaling Pathway

Open DOI

Saber Nehdi, Waleed Aldahmash, Abeer Alhazmi et al.

Despite the widespread use of silver nanoparticles (AgNPs) in consumer, industrial, and biomedical products, their potential effects on female reproductive health, particularly during critical developmental periods, remain insufficiently...

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05 31 August 2026

DOI 10.33549/physiolres.935816

Exploring the Regulatory Mechanism of Sodium Butyrate on Milk Fat Synthesis in Lactating Goats Fed a High-Concentrate Diet Based on Metabolomics Technology

Open DOI

Lin Li, Yanfen Lyu Hongxia Hou, Binbin Gong et al.

This study investigated the effects of sodium butyrate (SB) supplementation on milk fat synthesis in lactating goats fed a high-concentrate (HC) diet. Twelve lactating Saanen goats were randomly allocated into two groups: a control group...

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06 31 August 2026

DOI 10.33549/physiolres.935854

Metabolic Exhaustion, p38 MAPK/Rac1 GTPase/MLKL Signaling, and Ca2+ Influx Mediate Solasodine-Triggered Eryptosis

Open DOI

Iman A. Alajeyan, Jawaher Alsughayyir, Mohammad A. Alfhili

Solasodine (SOL) is a steroidal glycoalkaloid that shows a wide range of biological effects, most notably anticancer activities. Eryptosis is the programmed cell death of erythrocytes that leads to anemia. Specifically, chemotherapy-indu...

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07 31 August 2026

DOI 10.33549/physiolres.935803

The Defect of iNKT Cells Mediates Mitochondrial Dysfunction Through IL-6/STAT3 Signaling to Induce Atrial Inflammation and Fibrosis to Aggravate Postoperative Atrial Fibrillation

Open DOI

Xiao Tian, Guangshu Tian, Zhishuo Liu et al.

Atrial inflammation and fibrosis are the pathogenesis of postoperative atrial fibrillation (POAF). It has been reported that invariant natural killer T (iNKT) cells can coordinate tissue inflammation, but whether it can regulate POAF is ...

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08 31 August 2026

DOI 10.33549/physiolres.935812

Altered Expression of Energy Metabolism-Related Genes in Placental Trophoblast Cells in Preeclampsia

Open DOI

Xin Wang, Jing Wang, Ling-Chao Wang et al.

Preeclampsia (PE) is a pregnancy-specific hypertensive disorder characterized by new-onset hypertension after 20 weeks of gestation, with or without proteinuria, frequently accompanied by systemic arteriolar spasm and dysfunction or inju...

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09 31 August 2026

DOI 10.33549/physiolres.935810

Targeting Mitochondria in MASLD: Comparative Evaluation of MitoQ and SS-31 (Elamipretide) in Aged Female Mice under Nutritional Stress

Open DOI

Di Xiao, Xingxing Cui, Sajad Ali et al.

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a major cause of cirrhosis, liver cancer, and cardiovascular disease. Early mitochondrial dysfunction drives lipid imbalance, inflammation, and fibrosis. Given the lack ...

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10 31 August 2026

DOI 10.33549/physiolres.935743

Treadmill Exercise in Rats Attenuates Chronic Unpredictable Stress-Induced Depressive-like Behavior Associated with Melatonin–SIRT1/Nrf2 Signaling in the Prefrontal Cortex

Open DOI

Ji-Ping He, Xiao-Yun Su, Jie Men et al.

To explore the ameliorating effect of treadmill exercise on depression-like behavior in rats with chronic unpredictable stress (CUS). Thirty-six Sprague-Dawley rats were divided into three groups (n=12 per group): a control group, a CUS ...

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