Pharmaceutical research

01 15 October 2026

DOI 10.1007/s11095-026-04223-z

Long-lasting Inhibition of L-type Amino Acid Transporter 1 by Nanvuranlat is Associated with Prolonged Cellular Retention Counteracted by Cancer-type OATP1B3 in Cholangiocarcinoma Cells

Open DOI

Kiyoshi Oka, Yusuke Masuo, Atsunosuke Yamada et al.

Nanvuranlat (JPH203, NVL) is a selective L-type amino acid transporter 1 (LAT1) inhibitor that shows antitumor activity despite rapidly declining blood concentrations. This study investigated whether its long-lasting inhibition of LAT1 i...

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02 12 October 2026

DOI 10.1007/s11095-026-04222-0

Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

Open DOI

Ankita Dhiman, Rahul Singh, Rituraj Purohit

Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Models were generated using AlphaFold-Colab for f...

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03 12 October 2026

DOI 10.1007/s11095-026-04224-y

A Hierarchical Dual-barrier Nanoparticle System Combining Solid Lipid Nanoparticles and Enteric Coating for Effective Oral Insulin Delivery

Open DOI

Xinyi Che, Jingxin Gou, Xing Tang et al.

Oral delivery of insulin is limited by enzymatic degradation and instability in the gastrointestinal tract, as well as inefficient intestinal absorption. This study aimed to develop a dual-barrier oral insulin delivery system to protect ...

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04 12 October 2026

DOI 10.1007/s11095-026-04221-1

Screening of Unexplored FDA-approved Inactive Ingredients as Stabilizers for Monoclonal Antibody Products

Open DOI

Divya Agrawal, Charu Mittal, Avinash Mishra et al.

Monoclonal antibodies (mAbs) are susceptible to physical and chemical degradation, which can compromise product quality, efficacy, safety, and shelf life. Although excipients play a critical role in stabilizing mAb formulations, only a l...

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05 12 October 2026

DOI 10.1007/s11095-026-04212-2

Development of a Mechanistic Distribution Model for Predicting Drug Partitioning into Human Milk

Open DOI

Neel Deferm, Anna Murphy, Iain Gardner et al.

Limited clinical data on drug safety during lactation complicate benefit-risk assessment for breastfeeding women who require pharmacotherapy. Mechanistic prediction of the milk-to-plasma ratio within physiologically-based pharmacokinetic...

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06 8 October 2026

DOI 10.1007/s11095-026-04193-2

Correction: Quantification of Unencapsulated Drug in Target Tissues Demonstrates Pharmacological Properties and Therapeutic Effects of Liposomal Topotecan (FF-10850)

Open DOI

Toshifumi Kimura, Ken Okada, Yasushi Morohashi et al.

07 7 October 2026

DOI 10.1007/s11095-026-04138-9

Evaluating the Antimicrobial Activity of Curcumin-loaded Lipid Nanocarriers When Applying Photodynamic and Sonodynamic Therapy for the Treatment of Skin Infections

Open DOI

Omar Molina-Alejandre, Angélica Villanueva-Martínez, María Guadalupe Nava-Arzaluz et al.

Purpose: The antimicrobial activity of curcumin is the focus of this article, which sought to enhance it by formulating curcumin in lipid nanocarriers, and by applying Sonodynamic Therapy (ST) and Photodynamic Therapy (PT). Methodology: ...

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08 7 October 2026

DOI 10.1007/s11095-026-04204-2

Polar vs Non-polar Excipients in BSA Aggregation

Open DOI

Samuel Tien, Simone Nørgaard Krabbe, Annika Sollann Sørensen et al.

Purpose: In recent years, there has been a rapid expansion in the development of new protein therapeutics in the pharmaceutical industry. Problematically, proteins are conformationally and colloidally marginally stable, and thus it is ne...

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09 5 October 2026

DOI 10.1007/s11095-026-04216-y

Triazavirin And Its Derivatives Act As Influenza A Virus Fusion Inhibitors

Open DOI

Zaret G. Denieva, Egor S. Bulavko, Eva V. Bersneva et al.

10 2 October 2026

DOI 10.1007/s11095-026-04140-1

Matricaria chamomilla L. Essential Oil: The Preparation and Characterization of the Self-microemulsion Drug Delivery System, and Repair Effect in Ulcerative Colitis

Open DOI

Wanjing Rong, Michael Adu-Frimpong, Hong Chen et al.