Pain

01 14 November 2026

DOI 10.1097/01.j.pain.0001288788.94119.7e

Editorial Board

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02 14 November 2026

DOI 10.1097/01.j.pain.0001288792.76932.77

On the Cover

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03 19 October 2026

DOI 10.1097/j.pain.0000000000004124

Targeting GPR183 to reduce peripheral sensitization: evidence from rodent and human tissue analyses

Open DOI

Kyle Oberkrom, Kathryn Braden, Evelyn Li et al.

Peripheral sensitization is a key process in the development of painful inflammatory conditions, driven in part by immune-cell mediator release following tissue injury. The G protein–coupled receptor, GPR183, predominantly expressed on i...

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04 13 October 2026

DOI 10.1097/j.pain.0000000000004132

The analgesic efficacy of opioids in different application modalities for the treatment of breakthrough cancer pain—a systematic review with network meta-analysis

Open DOI

Hanns-Christian Dinges, Sophie Thiedmann, Johanna Weyland et al.

Breakthrough cancer pain episodes often require oral immediate release opioids or parenteral opioid treatment. Different formulations and application modalities have been approved for this condition. This study aimed to identify the most...

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05 13 October 2026

DOI 10.1097/j.pain.0000000000004069

Invisible cost of pain management by the current International Classification of Diseases coding system, a study in a tertiary care inpatient setting: erratum

Open DOI

Sarasate Eiamtanasate, Kannika Smithiseth, Nantthasorn Zinboonyahgoon et al.

06 13 October 2026

DOI 10.1097/j.pain.0000000000004129

Pain education in Brazilian medical schools: a national curriculum analysis

Open DOI

Thayna Caetano Alves Silva, Felipe Maia Domingues, Daiane Lazzeri Medeiros et al.

Pain is a leading cause of disability worldwide, yet undergraduate medical education remains insufficient to prepare future physicians for its assessment and management. The International Association for the Study of Pain (IASP) has prop...

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07 5 October 2026

DOI 10.1097/j.pain.0000000000004127

Beyond intensity: pain distribution shapes healthcare- and treatment-seeking beliefs in individuals with and without clinical pain

Open DOI

Tom Frankenstein, Sophia Intert, Tibor M. Szikszay et al.

Pain is commonly described in sensory terms, yet its spatial characteristics are rarely quantified. We investigated whether lay beliefs about pain distribution influence theoretical decisions to seek care and treatment preferences. In a ...

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08 5 October 2026

DOI 10.1097/j.pain.0000000000004126

Evoked alpha oscillatory activity is suppressed by prolonged elbow pain and modulated by repetitive transcranial magnetic stimulation

Open DOI

Nahian S. Chowdhury, Joshua D. Hoddinott, Wei-Ju Chang et al.

Alpha-band oscillatory activity, assessed using electroencephalography (EEG), is among the most widely studied neurophysiological markers of pain. However, the literature has focused predominantly on resting-state measures, leaving uncle...

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09 2 October 2026

DOI 10.1097/j.pain.0000000000004125

Brain gray matter changes across chronic pain trajectories: MRI evidence from 35,000 individuals

Open DOI

Katerina Zorina-Lichtenwalter, Carmen I. Bango, Bogdan Petre et al.

Chronic pain affects brain gray matter structure, but the magnitude, pattern, and reversibility of brain changes upon pain recovery remain unclear because of inconsistent findings from small-scale studies. We analyzed data from 35,052 UK...

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10 30 September 2026

DOI 10.1097/j.pain.0000000000004123

Pain as a predictive process in the brain: how the Bayesian brain generates, amplifies, and relieves pain

Open DOI

Stanley Lyndon, Srdjan S. Nedeljkovic

Pain is not a passive readout of nociceptor traffic; it reflects the brain's inference about bodily threat under uncertainty. Building on predictive processing, active inference, and the free energy principle, we frame acute, chronic, an...

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