Organic letters

01 22 October 2026

DOI 10.1021/acs.orglett.6c04497

Photoinduced Amination of α-CF3 Alkyl Bromides with Oxime Carbonates by Merging Energy Transfer and Boryl Radical-Mediated Halogen-Atom Transfer

Open DOI

Jian Song, Dahong Li, Jingfeng Luo et al.

Herein, we report a metal-free photoinduced amination of α-CF3 alkyl bromides with oxime carbonates, providing a broad scope of structurally diverse α-trifluoromethyl amines. Oxime carbonates function as bifunctional reagents that underg...

Read abstract

02 22 October 2026

DOI 10.1021/acs.orglett.6c03533

Visible-Light-Mediated Skeletal Editing of Furans to N -Aminopyrroles

Open DOI

Yan Lei, Lu-Lu Qin, Zhi-Peng Ye et al.

N-Aminopyrroles are privileged scaffolds in pharmaceuticals, agrochemicals, and bioactive natural products. Despite some advances in their synthesis, general and efficient routes to these motifs remain underexplored. Herein, we report a ...

Read abstract

03 21 October 2026

DOI 10.1021/acs.orglett.6c04088

Dual PCET-Enabled Chemoselective Decarboxylative Sulfinylation with N -Sulfinyl Phthalimides as Bench-Stable Sulfinyl Radical Precursors

Open DOI

Jin Yang, Wenhang Dong, Shaolei Xia et al.

Herein, we disclose N-sulfinyl phthalimides as a new class of bench-stable and readily accessible sulfinyl radical precursors for the direct decarboxylative sulfinylation of carboxylic acids to sulfoxides via a dual proton-coupled electr...

Read abstract

04 21 October 2026

DOI 10.1021/acs.orglett.6c04104

S -Arylsulfinamides via Photoredox-Catalyzed Arylation of N -Sulfinylamines with Diaryliodonium Salts

Open DOI

Polina V. Zaikina, Dmitry I. Bugaenko, Alexander V. Karchava

A transition-metal-free, visible-light-mediated S-arylation of N-sulfinylamines using diaryliodonium salts and eosin Y efficiently affords diverse S-arylsulfinamides. This protocol tolerates both symmetrical diaryliodonium salts and unsy...

Read abstract

05 21 October 2026

DOI 10.1021/acs.orglett.6c04451

Catalytic Substrate- and Site-Selective Transesterification

Open DOI

Chengyi Shan, King Hung Nigel Tang, Kazumasa Kon et al.

Substrate- and site-selective esterification is a powerful synthetic tool to reduce the number of steps required for the synthesis of complex molecules. To address the challenges associated with achieving such selectivity, a variety of s...

Read abstract

06 21 October 2026

DOI 10.1021/acs.orglett.6c03942

LaCl3-Enabled Synthesis of 2′- C -Substituted Galidesivir Analogues

Open DOI

James M. Wood, Rinu Shrestha, Ashley Nutsford et al.

The first synthesis of 2′-C-ethynylgalidesivir is reported. Access to this highly congested imino-C-nucleoside required development of a LaCl3·2LiCl-enabled addition of a 9-deazaadenine-derived Grignard reagent to 2′-C-substituted cyclic...

Read abstract

07 21 October 2026

DOI 10.1021/acs.orglett.6c04269

Nickel-Catalyzed Enantioselective Carbo-Carbonylation of Alkenes Using Formic Acid as a CO Surrogate: Access to Oxindoles Bearing Chiral Quaternary Carbon

Open DOI

Krishnamoorthy Kathirvel, Govindasamy Sekar

Carbonylation reactions typically rely on toxic carbon monoxide gas, often under pressurized conditions. Herein, we report an enantioselective nickel-catalyzed carbonylative difunctionalization of activated olefins using formic acid as a...

Read abstract

08 20 October 2026

DOI 10.1021/acs.orglett.6c04049

Structural Factors That Impact Thioimidate Isomerization and Peptide Backbone Conformation

Open DOI

Dionicio N. Reyes V, Katharina Tucker, Brendan J. Wall et al.

Thioimidates exhibit an unusual conformational equilibrium among peptide backbone functional groups, often populating their trans and cis isomers in nearly equal amounts. Despite their growing use as intermediates for peptide backbone ed...

Read abstract

09 20 October 2026

DOI 10.1021/acs.orglett.6c04068

Photoinduced Charge-Transfer Complex-Mediated Decarboxylative Phosphoniumation

Open DOI

Hailong He, Jiajin Chen, Hongyao Wang et al.

Phosphonium salts are valuable intermediates in organic synthesis, but their preparation often requires harsh conditions and specific carbon precursors. Herein, we report a photoinduced decarboxylative phosphoniumation of redox-active es...

Read abstract

10 20 October 2026

DOI 10.1021/acs.orglett.6c04105

TfOH/HFIP Cluster-Promoted Divergent C–C Bond Cleavage and Reconstruction of Alkynoic Acids

Open DOI

Yilin Xing, Xinyu Song, Yuanyuan Liu et al.

C–C bond cleavage and reconstruction of carboxylic acids is predominantly directed at the C–C(O) position. Herein, we have successfully developed a TfOH/HFIP cluster-promoted divergent strategy for the C–C bond cleavage of alkynoic acids...

Read abstract