Oncogene

01 19 October 2026

DOI 10.1038/s41388-026-04019-w

Activation of the endocytosis pathway stratifies subtypes and therapeutic sensitivity in colorectal cancer

Open DOI

Hiroyuki Arai, Andrew Elliott, Yan Yang et al.

Endocytosis regulates receptor trafficking and signaling, yet its role in colorectal cancer (CRC) remains unclear. We analyzed transcriptomic data from 15,025 CRC tumors to evaluate gene expression in clathrin-mediated endocytosis (CME) ...

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02 17 October 2026

DOI 10.1038/s41388-026-04015-0

Phosphorylation of IRS4 at YY111/112 promotes LUSC progression via PI3K/AKT pathway activation

Open DOI

Yilixiati Aihemaiti, Qiuhan Ren, Xiangling Jiang et al.

03 17 October 2026

DOI 10.1038/s41388-026-04023-0

Liver-specific amino acid metabolism impacts on efficacy of cancer immunotherapy

Open DOI

Yuma Fukumoto, Fumiaki Mukohara, Momoko Iwatsuru et al.

The combination immunotherapies, including those with atezolizumab and bevacizumab (Atez/Bev), have become standard therapy for hepatocellular carcinoma (HCC). However, its efficacy remains limited and reliable biomarkers are lacking. In...

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04 16 October 2026

DOI 10.1038/s41388-026-04018-x

Dual novel compounds destroy mitochondrial morphology and function to treat glioblastoma by promoting the p62-mediated protein degradation of mitochondrial respiratory chain complex

Open DOI

Hanyi Xu, Yanping Huang, Dongyuan Su et al.

Therapeutic efficacy of temozolomide (TMZ) remains limited, and GBM patients generally experience poor outcomes due to the presence of multiple mechanisms of TMZ resistance. Previously, we developed two novel compounds: EPIC-1027, which ...

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05 16 October 2026

DOI 10.1038/s41388-026-04017-y

Dynamic remodeling of the KRAS interactome by direct RAS inhibitors with distinct mechanism of action reveals convergent responses

Open DOI

Yang Yang, Tingyu Liu, Charles Y. Cho et al.

KRAS is mutated in 30% of all human cancers. Small molecule inhibitors targeting KRAS with distinct mechanisms-of-action and variable specificities have entered the clinic, but their full effect on the RAS signaling network remains uncle...

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06 15 October 2026

DOI 10.1038/s41388-026-04013-2

Methylation-driven SOX18 nuclear translocation by IGF2BP1-stabilized METTL21A promotes lymphatic metastasis in gastric cancer

Open DOI

Ruofan He, Yi Zhang, Songyi Liu et al.

Gastric cancer (GC) is frequently associated with lymph node metastasis, which contributes to a poor prognosis; however, the underlying molecular mechanisms remain incompletely understood. In this study, we identify the N6-methyladenosin...

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07 12 October 2026

DOI 10.1038/s41388-026-04008-z

TNFα-driven epigenetic upregulation of TIGIT creates a targetable vulnerability in tumors

Open DOI

Xuefeng Huang, Chaoyang Xiong, Minghang Yu et al.

T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a key inhibitory receptor on cytotoxic lymphocytes, yet the mechanisms governing its context-dependent upregulation in tumors remain poorly defined. Here, we identify tumor necros...

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08 12 October 2026

DOI 10.1038/s41388-026-04005-2

Correction: Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activation

Open DOI

Cheng Xu, Yunfei Wang, Qiu Tu et al.

09 10 October 2026

DOI 10.1038/s41388-026-04011-4

PTK7 scaffolds DNA-PKcs to promote DNA damage response and immune evasion in triple-negative breast cancer

Open DOI

Xueying Liu, Kejing Zhang, Yu Zhang et al.

10 10 October 2026

DOI 10.1038/s41388-026-04012-3

Adrenomedullin 2 drives intratumoral cancer cell invasion, intravasation and metastasis

Open DOI

Konstantin Stoletov, Seyedeh Sara Karimian, Douglas Brown et al.