Nature neuroscience

01 15 October 2026

DOI 10.1038/s41593-026-02470-2

Spatiotemporal AI-based modeling of gene regulation and variant effects in the developing human brain using Seal

Open DOI

Yun Hao, Christopher Y. Park, Chandra L. Theesfeld et al.

Understanding how genetic variation shapes gene regulation in the developing human brain remains a central challenge in neuroscience, particularly in transient cell types and developmental stages where data are limited. We present Seal, ...

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02 15 October 2026

DOI 10.1038/s41593-026-02490-y

5-HT2A receptors in layer 5 pyramidal neurons mediate the neuroplastic but not the hallucinogenic effects of psilocybin

Open DOI

Jacob J. Baker, Emily Kogan, Shaorong Ma et al.

It is unclear how serotonin 2A receptors (5-HT2ARs) in cortical layer 5 pyramidal neurons differentially contribute to psilocybin-induced hallucinations versus neuroplasticity. Here we show that psilocybin promotes synapse formation and ...

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03 15 October 2026

DOI 10.1038/s41593-026-02431-9

A half-center oscillator regulates sleep pressure

Open DOI

Peter S. Hasenhuetl, Raffaele Sarnataro, Eleftheria Vrontou et al.

Changes in oscillatory neural dynamics reflect—but may not necessarily determine—transitions between sleep stages and variations in sleep pressure. Here we show that sleep-control neurons innervating the dorsal fan-shaped body of Drosoph...

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04 15 October 2026

DOI 10.1038/s41593-026-02461-3

Periventricular gradient pathology is linked to ependymal reactivity and cell adhesion disruption in multiple sclerosis

Open DOI

Adam M. R. Groh, Elia Afanasiev, Risavarshni Thevakumaran et al.

Cerebrospinal fluid (CSF)-adjacent brain areas are especially vulnerable to diffuse degeneration in multiple sclerosis (MS). Surface-in gradients arising from CSF-borne cytotoxic factors have been proposed to predict disease relapses ind...

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05 15 October 2026

DOI 10.1038/s41593-026-02465-z

An aging-sensitive secreted phospholipase confers neuroprotection and cognitive resilience

Open DOI

Cinzia Vicidomini, Travis D. Goode, Ruilin Yu et al.

Cognitive reserve theory posits that compensatory mechanisms during aging stave off cognitive decline and lower risk for Alzheimer’s disease. Here, in a screen for hippocampal dentate granule cell (DGC) synapse loss-induced factors in mi...

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06 14 October 2026

DOI 10.1038/s41593-026-02394-x

Ring attractor networks go full circle

Open DOI

Francesca Mastrogiuseppe, Srdjan Ostojic

07 14 October 2026

DOI 10.1038/s41593-026-02452-4

Symmetries and continuous attractors in disordered neural circuits

Open DOI

David G. Clark, L. F. Abbott, Haim Sompolinsky

08 13 October 2026

DOI 10.1038/s41593-026-02502-x

Author Correction: T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis

Open DOI

Shreeya Kedia, Hao Ji, Ruoqing Feng et al.

09 12 October 2026

DOI 10.1038/s41593-026-02481-z

Genome-wide analysis of common structural variants in Alzheimer’s disease identifies a risk-associated regulatory CCG repeat in FAM193B

Open DOI

Han Cao, Yifan Fu, Xiaopu Zhou et al.

Although Alzheimer’s disease (AD) has a polygenic architecture, with numerous associated single-nucleotide polymorphisms (SNPs) identified, the contribution of structural variants (SVs) is unclear. In this study, using long-read (n = 11)...

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10 12 October 2026

DOI 10.1038/s41593-026-02462-2

Investigating molecular and hemodynamic effects of LSD in the human brain

Open DOI

Drummond E-Wen McCulloch, Kristian Larsen, Annette Johansen et al.

Lysergic acid diethylamide (LSD) is a potent psychedelic with increasing therapeutic interest, yet qualification of target engagement using in vivo neuroimaging has not yet been performed. Using simultaneous positron emission tomography-...

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