Mutagenesis

01 8 October 2026

DOI 10.1093/mutage/geag035

Correction: Decreased adiposity resulting from reduced food intake likely contributes to the amelioration of genotoxic alterations in Omega-3–supplemented cafeteria diet–fed mice

Open DOI

02 3 October 2026

DOI 10.1093/mutage/geag034

Assessment of the DNA lesion specificity of the comet assay in combination with DNA repair inhibitors (Aphidicolin and Hydroxyurea/Cytosine Arabinoside)

Open DOI

E Saenz-Martinez, A López de Cerain, A Azqueta

The standard alkaline comet assay is a straightforward and cost-effective genotoxicity test commonly used in genetic toxicology to detect strand breaks and alkali-labile sites in DNA. Furthermore, with certain modifications, other altere...

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03 3 September 2026

DOI 10.1093/mutage/geag033

Next generation nicotine product aerosol extracts exhibit reduced toxicological effects compared to cigarette smoke extracts in the ToxTracker antioxidant and ToxProfiler MAX assays

Open DOI

Matthew Stevenson, Roman Wieczorek, Edgar Trelles Sticken et al.

Smoking is a cause of serious diseases in adult smokers. Next generation products (NGP) can provide potentially reduced harm alternatives of nicotine delivery, due to the reductions in numbers and levels of toxicants associated with thei...

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04 2 September 2026

DOI 10.1093/mutage/geag030

Expanding the comet assay toolbox for human biomonitoring using frozen whole blood

Open DOI

Xu He, Ines Peremin, Roger Godschalk et al.

The comet assay is a widely used tool for evaluating DNA damage in various biological samples, with frozen whole blood (WB) as an attractive biomatrix, due to its ease of collection, handling, and storage. Although frozen WB has been suc...

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05 1 September 2026

DOI 10.1093/mutage/geag032

Tryptophan metabolism and aryl hydrocarbon receptor activation are associated with fecal water–induced DNA damage in patients with inflammatory bowel disease

Open DOI

Luping Chen, Shan Wang, Corinne Spooren et al.

Inflammatory bowel disease (IBD) is associated with alterations in the intestinal luminal environment that may modify the composition of fecal water (FW) and its capacity to induce DNA damage. The aim of this study was to identify FW met...

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06 28 August 2026

DOI 10.1093/mutage/geag031

Acute oral dose toxicity study of micro- and nano-plastics of polystyrene in female Wistar albino rats

Open DOI

Srilekha Chintala, Asra Fathima, Ramakrishna Kakarla et al.

Human exposure scenarios to emerging pollutants, microplastics (MPs), and nanoplastics (NPs) are increasing. However, in vivo reports defining their acute genotoxic hazard, particularly under combined (MPs + NPs) exposure are limited. Po...

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07 18 August 2026

DOI 10.1093/mutage/geag029

Decreased adiposity resulting from reduced food intake likely contributes to the amelioration of genotoxic alterations in Omega-3–supplemented cafeteria diet–fed mice

Open DOI

Isadora de Oliveira Monteiro, Ângela Caroline da Luz Beretta, Marina Lummertz Magenis et al.

Obesity is defined as the excessive accumulation of fat that can lead to the development of several diseases, such as type 2 diabetes and cardiovascular diseases. Dietary studies using animal models are essential to elucidate the mechani...

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08 7 August 2026

DOI 10.1093/mutage/geag028

Morphine modulates doxorubicin-induced genomic instability with distinct effects in osteosarcoma and fibroblast cells

Open DOI

Jayne Torres de Sousa, Rafael Rodrigues Dihl, Cristina Brauwers Kubiaki et al.

Osteosarcoma is an aggressive malignant bone tumor that often requires chemotherapy with agents such as doxorubicin (Dox), which is known for its potent cytotoxic and genotoxic effects. To manage cancer-related pain, morphine is widely u...

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09 9 July 2026

DOI 10.1093/mutage/geag027

Antioxidant and genoprotective effects of naturally occurring delphinidin glycosides

Open DOI

Giorgia Martelli, Carima Lörch, Naji Said Aboud Hadi et al.

Anthocyanins are flavonoid pigments responsible for red, blue, and purple coloration in plants and play a protective role against abiotic stress through reactive oxygen species (ROS) scavenging. They are abundant in the human diet, with ...

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10 9 July 2026

DOI 10.1093/mutage/geag026

Industrial genotoxicology group: 38th annual meeting report

Open DOI

Grace Kocks, Fahima Begum, Peter Ceuppens et al.

The 38th annual meeting of the Industrial Genotoxicology Group was held at Lhasa Limited, Leeds, UK, on 2 December 2025, and focussed on the assessment of biological relevance in genotoxicity testing and the appropriate use of historical...

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