mSphere

01 16 October 2026

DOI 10.1128/msphere.00473-26

Characterization of the Peromyscus leucopus immunoglobulin germline repertoire and anti-OspA antibody response reveals conserved germline IGHV features among cricetid rodents

Open DOI

Yu Zhou, Sam R. Telford, Joanna Buchthal et al.

Peromyscus leucopus ( P. leucopus ) is an important reservoir host for several zoonoses, including Borrelia burgdorferi ( B. burgdorferi ), the causative agent of Lyme disease. However, the immunoglobulin germline repertoire underlying a...

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02 14 October 2026

DOI 10.1128/msphere.00674-26

HIV-1 Tat protects macrophages from killing by the exoenzyme U from Pseudomonas aeruginosa

Open DOI

Maxime Jansen, Aurélie Rivault, Angéline Tellier et al.

People living with HIV (PLWH) have a higher risk of developing other diseases, such as bacterial pneumonia. Pseudomonas aeruginosa is a common cause of pneumonia in humans. The most virulent strains produce ExoU, which is a key effector ...

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03 14 October 2026

DOI 10.1128/msphere.00732-26

Erratum for Bernier Gosselin et al., “Associations of antimicrobial and multidrug resistance in Escherichia coli from the fecal flora and housing environment of calves on dairy farms with atmospheric variables”

Open DOI

Véronique Bernier Gosselin, Martin Wegmann, Romane Zufferey et al.

04 8 October 2026

DOI 10.1128/msphere.00593-26

The synthesis of niclosamide derivative as a novel colistin adjuvant for reversing colistin resistance and its antibacterial activity with colistin in vitro

Open DOI

Peiyi Liu, Yingbiao Li, Fanlun Ding et al.

Colistin (COL) serves as a last-line therapeutic agent against multidrug-resistant gram-negative bacteria (GNB) infections. Nevertheless, widespread clinical use of COL has led to severe bacterial resistance. The anthelmintic drug niclos...

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05 8 October 2026

DOI 10.1128/msphere.00601-26

The Agrobacterium fabrum efflux pump PecM serves as a critical metabolic relief valve to maintain cellular homeostasis

Open DOI

Arpita Ghosh, Ahmed Al-Tohamy, Fabrizio Donnarumma et al.

Agrobacterium fabrum infects a wide range of plants, resulting in significant economic losses. In the rhizosphere, the bacterium is exposed to several stressors, including compounds secreted from other bacteria, fungi, or plants. A. fabr...

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06 8 October 2026

DOI 10.1128/msphere.00403-26

Members of the Enterobacteriaceae family produce a diffusible signal factor that modulates enteric pathogen virulence

Open DOI

Paulina D. Pavinski Bitar, Rimi Chowdhury, Erick Maosa Bosire et al.

Diffusible signal factors (DSFs) are a gammaproteobacterial family of quorum-sensing signals that mediate the transition between sessile and planktonic lifestyles. In addition to coordinating behavior within producing species, DSFs can b...

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07 8 October 2026

DOI 10.1128/msphere.00433-26

Microbial communities on station and train surfaces in Chennai Metro: insights into urban transit microbiome

Open DOI

Vijaya Yuvaram Singh, Veerendra P. Gadekar, Srijith Sasikumar et al.

Urban public transport systems, particularly metro networks, serve as key hubs for microbial transmission, yet the urban microbiome in densely populated regions like India remains poorly characterized. Understanding these environments is...

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08 7 October 2026

DOI 10.1128/msphere.00594-26

Rate of osmotic pressure change in drying saliva microdroplets drives inactivation of model respiratory bacteria

Open DOI

Taylor Medina, Beiping Luo, Thomas Peter et al.

Transmission of respiratory pathogens depends on their ability to remain viable in drying respiratory droplets, yet the physicochemical drivers of bacterial inactivation during droplet evaporation remain poorly quantified. This study com...

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09 7 October 2026

DOI 10.1128/msphere.00427-26

Discovery of novel anti- Prototheca compounds with diverse modes of action through screening of a chemical library

Open DOI

Amir Aliramezani, Magdalena Widziolek, Łukasz Chajec et al.

Prototheca , a genus of unpigmented yeast-like microscopic algae, is an emerging pathogen of humans and animals. Treatment of Prototheca infections is often unsuccessful because the unusual algal biology of these pathogens limits the ava...

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10 7 October 2026

DOI 10.1128/msphere.00619-26

Tropolone and hinokitiol act against Staphylococcus aureus by concentration-dependent iron restriction or toxic iron overload

Open DOI

Bethany L. Hardman, Gary J. Sharples

Transition metal homeostasis is a critical component of bacterial physiology and thus represents a promising opportunity for antimicrobial intervention. Here, we demonstrate that the naturally occurring chelators tropolone (TRO) and hino...

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