Molecular neurobiology

01 16 July 2026

DOI 10.1007/s12035-026-06068-4

Astrocytic HMGCR-Mediated Cholesterol Alleviated Parkinson's Disease Phenotypes by Inhibiting NF-κB Neuroinflammation.

Open DOI

Xiaofeng Tian, Qing Liu, Jiacheng Zhang et al.

In recent years, the association between abnormal cholesterol metabolism and Parkinson's disease (PD) has attracted considerable attention, but the specific mechanism remains controversial. First, we used Mendelian Randomization (MR) ana...

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02 15 July 2026

DOI 10.1007/s12035-026-06033-1

Mitigating Fixation Artifacts in Spatial Transcriptomics: Methodological Insights from Human Brain Tissue.

Open DOI

Kassandra Georges, Maiken Krogsbaek, Sara Newell Jensen et al.

Human brain bank material offers a great potential for studying a wide range of diseases from psychiatric to degenerative disorders, stroke, and pain. Historically, the primary limitation has been the technical usability of long-term for...

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03 15 July 2026

DOI 10.1007/s12035-026-06047-9

Antioxidant Effects of Vitamin E and L-Carnitine on Hippocampal Histology, Epigenetics, and Cognition in Morphine-Exposed Mice.

Open DOI

Marzieh Alizadeh, Tahereh Haghpanah, Massood Ezzatabadipour et al.

Chronic exposure to morphine induces oxidative stress and alters the hippocampal expression of genes encoding enzymes involved in epigenetic modifications (e.g., DNA methyltransferases; DNMTs and Histonedeacetylases; HDACs) and apoptosis...

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04 15 July 2026

DOI 10.1007/s12035-026-06065-7

Plant-derived Natural Products in Neurological and Psychiatric Disorders: Mechanisms of Action and Synergistic Roles with Probiotics.

Open DOI

Mustafa M Shokr, Abdelghafar M Abu-Elsaoud, Seham M Al Raish

Plant-derived natural products have emerged as promising therapeutic agents for neurological and psychiatric disorders due to their diverse bioactive compounds and multi-target mechanisms of action. This review provides a mechanistic ove...

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05 15 July 2026

DOI 10.1007/s12035-026-06052-y

Exosome Biology at the Interface of Neurodegeneration and Therapeutic Innovation.

Open DOI

Dipan Maity, A Gowtham, Yogesh Mishra et al.

Neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, are defined by progressive neuronal loss, protein misfolding, and chronic neuroinflammation, yet effective disease-modify...

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06 14 July 2026

DOI 10.1007/s12035-026-06063-9

Neuroprotective Effect of Delicaflavone in Rotenone-induced Parkinson's Disease in Rats: Role of Nrf2/HO-1, NF-κB and PI3K/Akt/mTOR Pathways.

Open DOI

Wei Li, Xunxun Chen, Mengqi Gao et al.

Parkinson's disease is a progressive neurodegenerative disease characterized by degeneration of dopaminergic neurons in the substantia nigra, reduced striatal dopamine levels, mitochondrial dysfunction, oxidative stress, and neuroinflamm...

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07 14 July 2026

DOI 10.1007/s12035-026-06053-x

Ficus deltoidea Preserves Hippocampal Neuronal Integrity and Redox Balance in Oxidative Stress-Driven Alzheimer's Disease-Like Rat Model.

Open DOI

Alhaji Modu Bukar, Che Mohd Nasril Che Mohd Nassir, Michael Ayuba et al.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide, with oxidative stress playing a central role in its pathogenesis. Ficus deltoidea (FD), a medicinal plant rich in flavonoid...

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08 31 January 2026

DOI 10.1007/s12035-026-05708-z

Gulf War Illness: Neurological Impacts, Pathophysiological Insights, and Therapeutic Prospects

Open DOI

Fabian Mantilla, Nidhi Patel, Amanpreet K. Cheema et al.

Gulf War Illness (GWI) is a chronic, multi-system condition affecting a substantial proportion of veterans deployed during the 1990-1991 Gulf War. Neurological complications, including cognitive impairment, musculoskeletal pain, fatigue,...

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09 30 January 2026

DOI 10.1007/s12035-025-05654-2

Endoplasmic Reticulum Stress in Spinal Cord Injury: Pathological Roles, Molecular Targets, and Emerging Treatments: A Systematic Review

Open DOI

Seyed Mohammad Piri, Sajjad Ahmadpour, Mohammad Amin Habibi et al.

Spinal cord injuries (SCI) are associated with significant physical and economic burdens on individuals and healthcare systems. Research has shown that several molecular and cellular interactions significantly contribute to SCI progressi...

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10 30 January 2026

DOI 10.1007/s12035-026-05684-4

4E-BP2-dependent translational control in GABAergic interneurons is required for long-term memory

Open DOI

Ziying Huang, Niaz Mahmood, Konstantina Psycharis et al.

MRNA translational repression by eukaryotic initiation factor 4E-binding proteins (4E-BPs), plays a critical role in synaptic plasticity and the formation of long-term memory (LTM). Among the three 4E-BP paralogs, 4E-BP2 is the predomina...

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