Modern rheumatology case reports

01 6 October 2026

DOI 10.1093/mrcr/rxag095

A Unique Case of Granulomatosis with Polyangiitis Presenting with Proximal Muscle Weakness

Open DOI

Jason L Chen, Kaitlyn Baber, Jared Stillman et al.

Granulomatosis with polyangiitis (GPA) is a subtype of ANCA-associated vasculitis that can have a heterogeneous clinical presentation. Although classically involving the respiratory tract and kidneys, GPA can rarely present with predomin...

Read abstract

02 5 October 2026

DOI 10.1093/mrcr/rxag096

Golimumab-induced lupus erythematosus complicated by angioedema and anti–galactocerebroside antibody–positive dysphagia

Open DOI

Makoto Misaki, Toshiaki Shimizu, Reo Yamazato et al.

Drug-induced lupus erythematosus is an autoimmune condition that resembles systemic lupus erythematosus and occurs after exposure to specific medications, including tumor necrosis factor alpha inhibitors. We report a rare case of golimum...

Read abstract

03 5 October 2026

DOI 10.1093/mrcr/rxag098

Successful use of a Janus-kinase (JAK) inhibitor in chronic chikungunya arthritis refractory to conventional synthetic DMARDs: a case report

Open DOI

Jobson Lopes de Oliveira, José Kennedy Amaral, Igor Albuquerque Nogueira et al.

Chronic chikungunya arthritis is a debilitating post-viral inflammatory condition that clinically mimics rheumatoid arthritis and often requires long-term treatment with disease-modifying antirheumatic drugs. Treatment options are limite...

Read abstract

04 3 October 2026

DOI 10.1093/mrcr/rxag097

Sjögren disease and idiopathic inflammatory myopathy overlap presenting as complement-mediated thrombotic microangiopathy/atypical haemolytic uremic syndrome with a complement factor B variant: A case report

Open DOI

Momoka Hasegawa, Yoshia Miyawaki, Moe Sakamoto-Tokunaga et al.

Complement-mediated thrombotic microangiopathy (CM-TMA) is often triggered by autoimmune diseases; however, reports of CM-TMA in patients with Sjögren disease (SjD) and idiopathic inflammatory myopathy (IIM) are limited. We describe the ...

Read abstract

05 1 October 2026

DOI 10.1093/mrcr/rxag093

Anti-c-Mpl antibody-positive acquired amegakaryocytic thrombocytopenia with immune thrombocytopenia-like features in mixed connective tissue disease

Open DOI

Tatsuya Ueno, Shunjiro Kurihara, Kodai Kato et al.

Acquired amegakaryocytic thrombocytopenia is a rare cause of severe thrombocytopenia characterized by a marked reduction in bone marrow megakaryocytes and may be difficult to distinguish clinically from immune thrombocytopenia. Acquired ...

Read abstract

06 30 September 2026

DOI 10.1093/mrcr/rxag094

Tocilizumab for refractory cerebral arteritis in a patient with systemic lupus erythematosus: A case report

Open DOI

Yasuto Minegishi, Takehisa Ogura, Chihiro Imaizumi et al.

Cerebral arteritis is a rare (<1%) but life-threatening manifestation of systemic lupus erythematosus (SLE). The optimal treatment of cerebral arteritis in refractory cases remains unclear; conventional immunosuppressive therapy results ...

Read abstract

07 10 July 2026

DOI 10.1093/mrcr/rxag070

Polyarteritis Nodosa and Sarcoidosis Presenting with Myalgia and Myositis-Mimicking MRI Findings: A Report of Two Cases.

Open DOI

Masayuki Shinojima, Satoshi Kubo, Ippei Miyagawa et al.

Diseases presenting with muscle symptoms are diverse. We report two cases initially suspected of idiopathic inflammatory myopathies (IIMs) that were ultimately diagnosed as polyarteritis nodosa and sarcoidosis, respectively. Case 1 was a...

Read abstract

08 10 July 2026

DOI 10.1093/mrcr/rxag068

Infliximab for laryngopharyngeal involvement in Behçet’s syndrome

Open DOI

Miyu Wakatsuki, Hiroyuki Yamashita, Hiroshi Kaneko

Laryngopharyngeal involvement in Behçet’s syndrome is rare but clinically significant because it may cause severe odynophagia, dysphagia, and airway compromise. Optimal treatment has not been established, and irreversible structural sequ...

Read abstract

09 1 July 2026

DOI 10.1093/mrcr/rxag051

Early postoperative onset of immune thrombocytopenia in rheumatoid arthritis with concomitant systemic lupus erythematosus: a case report.

Open DOI

Kazuhiro Nishikawa, Takahito Suto, Satoshi Shinagawa et al.

Immune thrombocytopenia (ITP) is often already recognised as a pre-existing comorbidity before surgery and managed with interventions to maintain platelet counts at levels considered adequate for surgery. Acute postoperative onset of ITP...

Read abstract

10 29 June 2026

DOI 10.1093/mrcr/rxag089

Primary erythromelalgia associated with an SCN9A variant can mimic systemic lupus erythematosus in skin manifestations: A case report

Open DOI

Atsuko Tomikawa, Kazuyuki Meguro, Keishi Etori et al.

Primary erythromelalgia (PEM) is a rare autosomal dominant disorder characterised by episodic erythema and burning pain of the extremities, typically triggered by exercise or fatigue. PEM usually begins in childhood and is caused by gain...

Read abstract