mBio

01 16 October 2026

DOI 10.1128/mbio.01630-26

Acetate modulates host physiology and bacterial energetics to improve antibiotic efficacy during obesity-associated infection

Open DOI

Arsalan Hussain, Prateek Bhardwaj, Ashish Kumar Ray et al.

Antibiotic efficacy is conventionally attributed to the susceptibility of the infecting pathogen. However, obese patients experience disproportionately poor infection outcomes despite receiving antibiotics to which pathogens remain genet...

Read abstract

02 15 October 2026

DOI 10.1128/mbio.01645-26

Diversity of dirammox microorganisms

Open DOI

Gantuya Khasbaatar, Qun Han, Xiao-Kang Wang et al.

Our knowledge of the nitrogen cycle has been advanced by the discovery of anammox bacteria, ammonia-oxidizing archaea, and comammox bacteria, along with their high diversity. Direct ammonia oxidation (dirammox), a recently discovered het...

Read abstract

03 14 October 2026

DOI 10.1128/mbio.03545-25

Dual-barrier mechanism of superinfection exclusion in Newcastle disease virus: nucleoprotein and hemagglutinin-neuraminidase cooperate to block secondary infection

Open DOI

Kejia Lu, Xuhong Cao, Zhengwu Chang et al.

Superinfection exclusion (SIE) is a well-documented phenomenon in virology, wherein a primary viral infection prevents subsequent infection by the same or closely related viruses through various mechanisms. This phenomenon has been obser...

Read abstract

04 14 October 2026

DOI 10.1128/mbio.01683-26

A novel adenovirus 19K/IX protein enhances infection by attenuating proteasomal degradation of tyrosine-ubiquitinated capsid protein IX

Open DOI

Erik Schubert, Vasileios Rafail Evangelopoulos, Mårten Larsson et al.

Human adenoviruses (HAdVs) are double-stranded DNA viruses that cause a wide range of diseases, including respiratory, ocular, and gastrointestinal infections. HAdVs rely extensively on alternative splicing to expand their coding capacit...

Read abstract

05 14 October 2026

DOI 10.1128/mbio.02090-26

HIV-1 hijacks HGF/c-MET signaling to promote viral entry and replication in primary CD4 + T cells

Open DOI

Shraddha Tripathi, Madeleine M. Allen, Li Wu

The mesenchymal-epithelial transition factor (c-MET) is a receptor tyrosine kinase best known for mediating hepatocyte growth factor (HGF) signaling in cancer, but its role in HIV-1 infection has remained unclear. Here, we identify c-MET...

Read abstract

06 14 October 2026

DOI 10.1128/mbio.02176-26

A protective hybrid protein vaccine informed by mapping major histocompatibility class II epitopes in Cryptococcus neoformans chitin deacetylases that stimulate CD4 + T-cell responses

Open DOI

Charles A. Specht, Lorena V. N. Oliveira, Diana Carlson et al.

Infections due to Cryptococcus species are estimated to cause over 100,000 deaths a year. No cryptococcal vaccines are approved for human use. We have shown that vaccine formulations consisting of C. neoformans chitin deacetylase 2 (Cda2...

Read abstract

07 14 October 2026

DOI 10.1128/mbio.02247-26

Pan-proteome regulation of marine Synechococcus nutrient stress plasticity

Open DOI

Nathan S. Garcia, Mak A. Saito, Renne Harcourt et al.

Variable phytoplankton resource demands can buffer productivity to climate-driven declines in nutrient supply, but the extent of this buffering depends on limits to cellular elemental plasticity. Elemental plasticity is driven by a combi...

Read abstract

08 14 October 2026

DOI 10.1128/mbio.00214-26

Monoclonal antibodies raised against the Junín virus glycoprotein show broad reactivity and provide protection in vivo

Open DOI

Garazi Pena Alzua, Sharon Jan, Fatima Amanat et al.

Argentine hemorrhagic fever (AHF) is a disease caused by the Junín virus (JUNV) that can be fatal in 15%–30% of untreated cases. Although JUNV is the only arenavirus for which efficient therapy and vaccination have been established, its ...

Read abstract

09 14 October 2026

DOI 10.1128/mbio.01933-26

Establishment of an ex vivo vascular tissue model to investigate bunyavirus-triggered vascular endothelial injury

Open DOI

Zihan Guan, Xi Chen, Yujie Fang et al.

Severe fever with thrombocytopenia syndrome, an emerging infectious disease caused by the tick-borne bunyavirus severe fever with thrombocytopenia syndrome virus (SFTSV), is associated with a high clinical fatality rate of 12%–50%. Vascu...

Read abstract

10 14 October 2026

DOI 10.1128/mbio.00244-26

Altered physiology of drug-resistant Mycobacterium tuberculosis restricts adaptation to host-relevant conditions and produces condition-dependent collateral vulnerabilities

Open DOI

William J. Jowsey, Kate R. Harding, Caitlin E. Cunniffe et al.

Antibiotic resistance mutations often disrupt essential cellular processes; however, the physiological consequences of these mutations under host-relevant conditions remain poorly understood in many bacterial pathogens. Here, we have use...

Read abstract