Journal of molecular cell biology

01 16 October 2026

DOI 10.1093/jmcb/mjag040

Medium-Frequency Electrotherapy-Driven Remodeling of Tumor Biology and Overcoming Treatment Resistance: Molecular Mechanisms and Clinical Integration

Open DOI

Xiumin Wu, Yao Liu, Zhifei He et al.

Electrotherapy exerts antitumor effects by applying specific electric currents or fields to tumor tissues, inducing biological responses through thermal, non-thermal, and electrochemical mechanisms. In recent years, electrotherapy has em...

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02 15 October 2026

DOI 10.1093/jmcb/mjag041

A histological staining identifies malignancy-correlated stromal vimentin across human cancer tissues

Open DOI

Qianyue Chen, Xuedi Gao, Chenglin Miao et al.

03 8 October 2026

DOI 10.1093/jmcb/mjag038

A Deep Learning system for Automated Quality Control of Medical Questionnaire data in Large-Scale Cohort Studies

Open DOI

Minmin Cao, Yanan Duan, Dong Lang et al.

Recent advances in natural language processing combined with deep learning have transformed disease prediction, diagnosis, and treatment, yet their application in automated quality control of medical questionnaire data remains largely un...

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04 29 September 2026

DOI 10.1093/jmcb/mjag037

Wdr5 Modulates Synaptic Development and Memory Consolidation in the Hippocampus and Cerebral Cortex

Open DOI

Huishan Wang, Wei Li, Pengcheng Ma et al.

WD-repeat domain 5 (Wdr5), a core component of the SET1/MLL family of histone methyltransferases, is widely involved in the regulation of development, epigenetic control, transcription, and cell division. Wdr5 has been linked to neurodev...

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05 1 September 2026

DOI 10.1093/jmcb/mjag036

Immune licensing of exercise: B cells wire a liver–muscle glutamate axis

Open DOI

Yiqi Yu, Rong Rong, Weiwei Dai

06 29 August 2026

DOI 10.1093/jmcb/mjag035

Jer1–Ga2–LpR1 axis mediates upstream input of alpha-mannosidosis

Open DOI

Wenting Li, Shengnan Li, Qi Wang et al.

Alpha-mannosidosis (AMD) is a well-known lysosomal storage disorder caused by the loss of α-mannosidase activity due to the mutation of the MAN2B1 gene. Defective α-mannosidase cannot completely degrade the sugar chains of upstream input...

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07 29 August 2026

DOI 10.1093/jmcb/mjag034

MAD2B guides chromosome stability in mitosis via the MAD2B–CIP2A signaling axis

Open DOI

Umer Ejaz, Fangyuan Xiong, Hengyi Shao et al.

Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, monitored by the spindle assembly checkpoint machinery, which prevents precocious chromosome segregation and reduces the risk of aneuploidy. MAD2B, a h...

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08 26 August 2026

DOI 10.1093/jmcb/mjag033

LAMTOR1 sorts APP to late endosomes via AP-3-mediated trafficking

Open DOI

Chenqian Zhou, Wenyuan Cao, Rixu Cong et al.

β-Amyloid precursor protein (APP), an amyloid β-peptide (Aβ) generating protein, plays a central role in Alzheimer’s disease (AD). Its intracellular trafficking and proteolytic processing are precisely regulated, but the mechanisms remai...

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09 19 August 2026

DOI 10.1093/jmcb/mjag031

Topoisomerase 1 initiates biliary-derived liver regeneration through the Dnmt1–p53 axis

Open DOI

Chuanfang Qian, Zhuolin Yang, Xuemeng Xu et al.

In end-stage liver disease, impaired hepatocyte proliferation prevents regeneration. Biliary epithelial cell transdifferentiation thus becomes a critical alternative for liver repair, yet its efficiency remains low in mammals. Elucidatin...

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10 17 August 2026

DOI 10.1093/jmcb/mjag030

ALKBH3 is an NPM1-dependent nucleolar protein required for rRNA biogenesis and translation

Open DOI

Xixi Ma, Yuliang Huang, Hao Jin et al.

The nucleolus is a membraneless nuclear organelle formed by liquid–liquid phase separation and serves as the hub for ribosomal RNA (rRNA) transcription and ribosome assembly. Here, we identify ALKBH3, a Fe(II)/α-ketoglutarate-dependent d...

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