Impact Factor
4.73
Journal Citation Impact
Estimated influence, citation density, publishing volume, and citation integrity from the analytics table.
Citation rate
7.83
17,810 total citations
h5-index
111
h5 depth signal
Cited share
89.9%
2,080 of 2,314
Total citations
17,810
Citation footprint
Metric signal
7.72
External metric anchor
Self-citation
10.2%
1,824 self-citations
Citations Trend
Monthly Publications Cadence
Citing Geographic Demographics
United States
3,286
China
3,155
Germany
989
United Kingdom
884
Italy
699
Citing Fields of Research
Cancer, Autophagy & Apoptosis
1,799
Cancer Drugs
1,005
Drug Delivery Systems
958
Immunology
951
Protein Structure & Folding
860
Publishing Activity & Reach
Volume, recency, access pattern, and citing-community signals from the journal analytics record.
All-time article footprint
40,638
Articles tracked across the journal lifetime
Indexed publication set
2,314
2,080 cited publications
Last 12 months
1,592
132.7 publications/month
Open access share
21.5%
343 OA publications in the last year
Leading citing country
United States
3,286 citing publications
Leading citing field
Cancer, Autophagy & Apoptosis
1,799 citing publications
Latest tracked publication
18 October 2026
10 recent records available
Coverage & Indexing History
v8n4,Jul. 1965-
v8n4,Jul. 1965-
Active Coverage
Active Coverage
Research Focus & Classification
Indexed Subjects
Cancer, Autophagy & Apoptosis
Immunology
Drug Delivery Systems
Cancer Drugs
Breast Cancer
Oncology
Radiation & Isotope-Based Techniques
Issuing & Sponsoring Bodies
Contributor
American Chemical Society
Broad Categories
Chemistry
Cancer, Autophagy & Apoptosis
Immunology
Molecular & Cellular Toxicology
Cellular Membrane Transporters & Receptors
Protein Structure & Folding
Radiochemistry
Immunotherapy
MeSH Descriptors
Chemistry, Pharmaceutical
Latest Publications
Recent article records with DOI-first linking and condensed abstracts.
01
DOI 10.1021/acs.jmedchem.6c00563
Open DOI
Cascade Mono- and Di-Functionalization of Anticancer Diastereomeric Benzoxazole-Ansamycins toward the Development of Highly Potent Hsp90 Inhibitors of Decreased Toxicity in Normal Cells
To reduce toxicity of geldanamycin (GDM), the domino transformation of its benzoquinone core into benzoxazole has been performed. Structural studies of ester-phenol and ester-ether benzoxazole-type ansamycins indicate that the former is ...
02
DOI 10.1021/acs.jmedchem.6c01450
Open DOI
Ligands Targeting α9-Containing Nicotinic Acetylcholine Receptors: Structure−Activity Relationships and Therapeutic Potential in Neuropathic Pain
Neuropathic pain remains a significant clinical challenge due to the varying efficacies and aversive effects associated with the currently available treatments. Most notably, the addiction potential associated with opioid use for pain pr...
03
DOI 10.1021/acs.jmedchem.6c01914
Open DOI
Discovery of Epoxysuccinates as Potent Covalent Inhibitors of SARS-CoV-2 Papain-like Protease
The papain-like protease (PLpro) of SARS-CoV-2, essential for viral processing and immune evasion, is a promising therapeutic target for coronavirus infections. Incorporating strategies used to enhance activity of non-covalent inhibitors...
04
DOI 10.1021/acs.jmedchem.6c02325
Open DOI
De Novo Design of Multi-Mechanistic AIE Photosensitizer for Broad-Spectrum Bacterial Eradication
Antibiotic resistance poses a serious threat to human health. Inspired by the clinical practice of employing drug combinations to achieve combined effects, we hypothesized that integrating multiple mechanisms into a single molecule could...
05
DOI 10.1021/acs.jmedchem.6c02769
Open DOI
gem -Dimethylcarbinol: A tert -Butyl Bioisostere with Greatly Reduced Lipophilicity
The tert-butyl group is a large substituent that could be useful in some contexts for filling protein pockets, but this highly lipophilic group typically worsens the ADMET properties of the parent scaffold. Although many bioisosteres of ...
06
DOI 10.1021/acs.jmedchem.6c02247
Open DOI
Design, Synthesis, and Biological Evaluation of Pentacyclic Triterpene Derivatives as Intestinal FXR Antagonists for Type 2 Diabetes
Intestinal farnesoid X receptor (FXR) antagonism has emerged as a strategy to enhance endogenous glucagon-like peptide-1 (GLP-1) secretion and improve metabolic control in type 2 diabetes mellitus (T2DM). Dihydrooleanolic acid methyl est...
07
DOI 10.1021/acs.jmedchem.6c02155
Open DOI
A Novel Small-Molecule Antagonist of the NOD1 Signaling Pathway as a Therapeutic Strategy for Acute Pancreatitis
Acute pancreatitis (AP) is a sterile inflammatory disease characterized by aberrant zymogen activation, tissue autodigestion, and cross-amplifying inflammatory cascades that complicate targeted therapies. Our single-cell transcriptomics ...
08
DOI 10.1021/acs.jmedchem.6c01856
Open DOI
Dual Peptide Modification via Isopeptide Bonding and Lipidation Boosts Antifungal Activity
The rapid rise in drug-resistant infectious diseases urgently demands new therapeutic strategies, particularly against fungi. Antimicrobial peptides (AMPs) are key effectors of innate immunity in all organisms, killing various microorgan...
09
DOI 10.1021/acs.jmedchem.6c02281
Open DOI
Enhancing the Specificity of the CAIX-Targeted Radionuclide Probe via the Optimization Cyclic Peptide Cyclization Linker
Carbonic anhydrase IX (CAIX) is a key biomarker for clear cell renal cell carcinoma (ccRCC) PET imaging. The reported probe 68Ga-DPI-4452 strongly targets both hCAIX and hCAII, therefore hindering its clinical applications. This study de...
10
DOI 10.1021/acs.jmedchem.6c02225
Open DOI
Design, Synthesis and Dual-Stage Antimalarial Evaluation of β-Carboline−Metronidazole Hybrids: Structure−Activity Relationship and Molecular Docking Correlations
Malaria remains a major global health challenge, exacerbated by emerging drug-resistant Plasmodium strains. Herein, we report the design, synthesis, and dual-stage antimalarial evaluation of β-carboline−metronidazole hybrids. The synthes...
Bibliographical & Catalog Notes
Title from cover.
Some issues for 1978?- accompanied by supplementary material on microfiche; Mar. 17 1995?- by supporting information on microfiche.
Also issued online.
Vol. 33, no. 1 (JAN 1990)19890828 Notice not published Printed on acid-free paper