Journal of clinical pharmacology

01 16 October 2026

DOI 10.1002/jcph.70313

Pain Severity Trajectories and Patient Profiles in Chronic Pain Patients Treated with Cannabis‐Based Medicinal Products: A k‐Means Clustering Analysis of the UK Medical Cannabis Registry

Open DOI

Simon Erridge, Aritra Datta, Aditya Mukherjee et al.

Cannabis‐based medicinal products (CBMPs) are increasingly prescribed for chronic pain, yet the supporting evidence remains limited and the extent to which patients differ in their response is poorly understood. This study applied longit...

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02 15 October 2026

DOI 10.1002/jcph.70312

Concentration‐QTc Analysis Supporting Thorough QT Study Waiver for Forvisirvat: Electrocardiogram Assay Sensitivity Demonstrated via Meal Effect

Open DOI

Yushi Kashihara, Yoshiyuki Igawa, Kei Okita et al.

Concentration‐QTc analysis from Phase 1 studies is increasingly used to evaluate QTc prolongation risk as an alternative to thorough QT (TQT) studies. According to International Conference on Harmonization E14 documents, such analyses sh...

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03 14 October 2026

DOI 10.1002/jcph.70308

Mechanistic Prediction of Maternal, Fetal, and Amniotic Fluid Betamethasone Concentrations to Support Dosing Optimization in Pregnancy

Open DOI

Alaa Mahdi, Khaled Abduljalil, Fernanda de Lima Moreira et al.

Respiratory distress syndrome (RDS) remains a major cause of neonatal mortality following premature birth. Antenatal betamethasone is the standard of care to accelerate fetal lung maturation and improve neonatal outcomes; however, curren...

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04 13 October 2026

DOI 10.1002/jcph.70307

Fostering Clinical Pharmacology and Drug Development in India: A Perspective From SAC‐ACCP

Open DOI

Karthik Venkatakrishnan, Abhigyan Ravula, Sagar Bachhav et al.

Since its inception in 2006, the South Asian College, Affiliate of the American College of Clinical Pharmacology (SAC‐ACCP), headquartered in Mumbai, India, has fostered the discipline, emphasizing education, training and dialogue across...

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05 12 October 2026

DOI 10.1002/jcph.70310

Development and Evaluation of a Population Pharmacokinetic Model for High‐Dose Methotrexate in Japanese Pediatric Patients with Acute Lymphoblastic Leukemia

Open DOI

Takuya Suzuoka, Tsubura Noda, Kota Tsuge et al.

Methotrexate is a key chemotherapeutic agent for treating pediatric acute lymphoblastic leukemia (ALL); however, its pharmacokinetics exhibit substantial inter‐individual variability. Population pharmacokinetic (PPK) models have identifi...

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06 6 October 2026

DOI 10.1002/jcph.70301

ACCP Call to Action—The Need for Vaccine Education

Open DOI

Kenneth Todd Moore, Sindura Gollamudi, Amir S. Youssef

07 6 October 2026

DOI 10.1002/jcph.70302

A Brief Review of Vaccine History, Hesitancy, and Education Today

Open DOI

Amir S. Youssef, Aman Gupta, Sindura Gollamudi et al.

Vaccination remains one of the most effective global health interventions, preventing substantial morbidity and mortality and advancing population health worldwide. However, vaccine hesitancy continues to limit vaccine confidence and upt...

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08 29 September 2026

DOI 10.1002/jcph.70305

Evaluation and Extrapolation of a Tacrolimus Population Pharmacokinetic Model in Adult Recipients of Allogeneic Hematopoietic Cell Transplantation Receiving Post‐Transplant Cyclophosphamide

Open DOI

Riley M. Randolph, Tyler C. Dunlap, Stephany Gonzalez Tineo et al.

Allogeneic hematopoietic cell transplant (allo‐HCT) is potentially curative for many hematologic diseases but complicated by acute graft‐versus‐host disease (aGVHD). While tacrolimus remains the cornerstone of aGVHD prophylaxis, regimens...

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09 29 September 2026

DOI 10.1002/jcph.70264

Physiologically Based Pharmacokinetic Modeling to Characterize the Disposition of Topiramate in Children with and without Obesity

Open DOI

Patricia D. Maglalang, Daniel Gonzalez, William J. Muller et al.

Topiramate (TPM) is used to treat seizures in adults and children ≥2 years. In children, TPM dosing is body weight based. It is unknown whether children with obesity may benefit from an alternative dosing strategy. We developed a novel p...

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10 29 September 2026

DOI 10.1002/jcph.70258

Exposure–Response Analyses of Ropeginterferon Alfa‐2b in Essential Thrombocythemia

Open DOI

Albert Qin, Lucia Masarova, Haoqi Chen et al.

Ropeginterferon alfa‐2b is a new‐generation interferon therapy for the treatment of myeloproliferative neoplasms (MPNs), including essential thrombocythemia (ET). This investigation was designed to characterize its population pharmacokin...

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