Journal of cell science

01 20 October 2026

DOI 10.1242/jcs.264721

cAMP signaling promotes acute lysosome biogenesis through TFEB nuclear import-export dynamics.

Open DOI

Saumya Bhatt, Mohammad Ali Abbas Zaidi, Hadley R. Taggart et al.

Cyclic adenosine monophosphate (cAMP) signaling is a major stimulus for lipid and glucose catabolism, yet catabolic processes like these can also coordinate with lysosome-dependent degradation. However, the impact of cAMP signaling on ly...

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02 16 October 2026

DOI 10.1242/jcs.264945

Septins as novel regulators of podosome cluster organization and dynamics in human immature dendritic cells

Open DOI

Koen van Den Dries, Rozanne Straten, Alessandra Cambi

Podosomes are actin-rich adhesions that enable cells to probe their environment, migrate across tissue boundaries, and degrade extracellular matrix. They are often organized in clusters, where their spatial organization is governed by co...

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03 14 October 2026

DOI 10.1242/jcs.265097

Visualisation of the regulation of CDK/cyclin complexes by p21 (CDKN1A) in living cells using FLIM-FRET

Open DOI

Christian Melle, Birgit Hoffmann, Annett Wiesenburg et al.

The cell cycle is controlled in G1-phase by activities of three cyclin-dependent kinases (CDKs), CDK4/6 and CDK2, and their regulatory partners, cyclin D and cyclin E, respectively. p21 (CDKN1A), a member of the KIP/CIP family, is involv...

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04 14 October 2026

DOI 10.1242/jcs.264805

Two-step regulation of bouquet formation by mating pheromone signaling and Pat1 activity reduction during fission yeast meiosis

Open DOI

Alimul Islam, Shinnosuke Kawai, Ayumu Yamamoto

Upon meiosis initiation in the fission yeast Schizosaccharomyces pombe, centromeres detach from the spindle pole body (SPB), while telomeres cluster at the SPB, forming the bouquet, which promotes homologous chromosome pairing. Bouquet f...

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05 14 October 2026

DOI 10.1242/jcs.265358

First person – Iván Hidalgo-Cenalmor

Open DOI

First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Iván Hidalgo-Cenalmor is first author on ‘ Nuclei...

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06 14 October 2026

DOI 10.1242/jcs.265152

NucleiSky enables cross-scale multimodal registration of microscopy data using nuclei constellations

Open DOI

Iván Hidalgo-Cenalmor, Adán Olguín-Olguín, Carolina Prieto et al.

Integrating tissue-level organisation with subcellular resolution and molecular information often requires combining multiple microscopy modalities and scales. However, aligning images acquired with different modalities, settings or inst...

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07 12 October 2026

DOI 10.1242/jcs.265305

First person – Harshath Amal

Open DOI

First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Harshath Amal is first author on ‘ TGF-β signalin...

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08 12 October 2026

DOI 10.1242/jcs.264997

TGF-β signaling modulates adhesion and actomyosin contractility to pattern epithelial permeability in Drosophila ovaries

Open DOI

Harshath Amal, Thea Jacobs, Max Lohrberg et al.

Epithelial morphogenesis and homeostasis depend on dynamic remodeling of cell–cell junctions. Tricellular junctions (TCJs) control epithelial permeability and plasticity, yet how TCJs are remodeled remains unclear. In the Drosophila ovar...

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09 9 October 2026

DOI 10.1242/jcs.265349

A phosphoinositide and RAB switch controls early macropinocytosis

Open DOI

Hélène Spangenberg, Emilie Løgith Moe, Øyvind Ødegård Fougner et al.

Macropinocytosis is a non-selective endocytic process by which cells take up large amounts of extracellular fluid into giant vesicles known as macropinosomes. This mechanism is used by immune cells to sample the surroundings for antigens...

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10 9 October 2026

DOI 10.1242/jcs.265075

FRET imaging of ERK activity in an orthotopic xenograft model of patient-derived pancreatic ductal adenocarcinoma using imaging window

Open DOI

Houssam Al-Koussa, Daisuke Taniguchi, Masafumi Kuroda et al.

Intravital imaging of cancer xenograft models enables the observation of cells in their tissue microenvironment. Application of molecular activity probes to intravital imaging, however, often poses technical difficulties. Here we sought ...

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