Journal of cancer research and clinical oncology

01 18 October 2026

DOI 10.1007/s00432-026-06643-1

Clinicopathological features and prognostic outcomes in pancreatic ductal adenocarcinoma with elevated alpha fetoprotein: a single-center retrospective study

Open DOI

Haonan Liu, Ruiqi Cao, Shengzhan Zhang et al.

02 16 October 2026

DOI 10.1007/s00432-026-06646-y

Management of extravasations of enfortumab vedotin and pembrolizumab: a case report and mini review of the current literature

Open DOI

Hendrik Dinkel, Konstantin E. Seifert, Martin Bögemann et al.

Following the EV-302/KEYNOTE-A39 study, the combination therapy of enfortumab vedotin and pembrolizumab (EV-P) has been established as a new first-line treatment for metastatic urothelial carcinoma. With increasing use, the documentation...

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03 16 October 2026

DOI 10.1007/s00432-026-06642-2

CT-to-surgery interval and occult nodal metastasis in cN0 oral squamous cell carcinoma

Open DOI

Jannik Ketschau, Jonathan Mohr, Alex Grabenhorst et al.

Background: CT-based staging of the clinically node-negative (cN0) neck in oral squamous cell carcinoma (OSCC) has limited sensitivity, and occult nodal metastasis remains common. Whether the CT-to-surgery interval influences pathologica...

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04 15 October 2026

DOI 10.1007/s00432-026-06622-6

Aqueous and flavonoid-rich Carica papaya leaf extracts modulate 7, 12-dimethylbenz[a]anthracene-induced breast carcinogenesis in rats: roles of oxidative stress, inflammation, and in silico docking

Open DOI

Doris Olachi Alilonu, Sunday Oge Elom, Azubuike Peter Ebokaiwe et al.

Purpose: Carica papaya leaves (CPL), traditionally used in ethnomedicine to manage inflammatory conditions and as an adjuvant in therapies, have been reported to have anticancer potential. This study investigated the chemopreventive and ...

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05 13 October 2026

DOI 10.1007/s00432-026-06598-3

A cross-sectional analysis of biopsychosocial distress among oncology patients in Limpopo, South Africa

Open DOI

Takalani Friddah Rafundisani, Dorah Ursula Ramathuba, Maria Sonto Maputle

Background: Cancer is a major global health burden associated with substantial mortality and long-term biopsychosocial challenges. In South Africa, limited oncology infrastructure and inequitable access to cancer care may contribute to d...

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06 12 October 2026

DOI 10.1007/s00432-026-06620-8

ARL4C in oral cancer cells promotes stromal RANKL expression via a RelA-dependent inflammatory axis in stromal fibroblasts

Open DOI

Thinh Thi Kim Truong, Shinsuke Fujii, Kana Hasegawa et al.

Purpose: Jawbone destruction in oral squamous cell carcinoma (OSCC) is driven by receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-mediated osteoclastogenesis. Although the cellular sources of RANKL and its regulatory mechan...

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07 11 October 2026

DOI 10.1007/s00432-026-06637-z

Chemotherapy-associated hyponatremia during curative-intent salvage therapy for very late relapse of central nervous system germinoma: a case-based review

Open DOI

Ryotaro Ohkuma, Toshiaki Tsurui, Tomoyuki Ishiguro et al.

Central nervous system germinoma is highly curable, but very late relapse and chronic endocrine sequelae can complicate salvage treatment. Herein, we report a 22-year-old man with central diabetes insipidus and panhypopituitarism who dev...

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08 10 October 2026

DOI 10.1007/s00432-026-06636-0

Nasopharyngeal carcinoma incidence and survival trends in the United States: a population-based analysis of two decades

Open DOI

Zhenchao Zhu, Chuan Lu, Wumei Huang et al.

09 9 October 2026

DOI 10.1007/s00432-026-06641-3

Bioinformatic landscapes of TTK-mediated ceRNA networks: new horizons for targeted therapy in lung adenocarcinoma

Open DOI

Prachi Patidar, Bhavika Baweja, Chainsee Saini et al.

Objective: This study identifies TTK as a prognostic LUAD biomarker regulated by a ceRNA network, driving immune evasion and therapeutic resistance. Methods: An integrated in silico approach was employed using OncoMX, KM Plotter, UALCAN,...

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10 3 October 2026

DOI 10.1007/s00432-026-06630-6

Evaluation of novel targeted small-molecule therapeutics in desmoplastic small round cell tumor (DSRCT) cells

Open DOI

Anne Hahn, Julia Hentschel, Shifa Saleem et al.

Purpose: Desmoplastic small round cell tumor (DSRCT) is an aggressive sarcoma associated with an extremely poor prognosis. This study evaluates the therapeutic potential of targeted, non-DNA-damaging small-molecule inhibitors in an in vi...

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