Journal of applied toxicology : JAT

01 19 October 2026

DOI 10.1002/jat.70479

Metal Accumulation, Liver Histopathology, and Human Health Risk Assessment Across Different Trophic Guilds in a Mining‐Affected Neotropical River

Open DOI

Breno Thuller, Alessandro Loureiro Paschoalini, Fabio Pereira Arantes et al.

Metal pollution in aquatic environments represents a recurring global concern; however, traditional paradigms often assume linear bioaccumulation patterns that may fail under catastrophic contamination scenarios. This study evaluated met...

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02 19 October 2026

DOI 10.1002/jat.70483

Toxicological Assessment of Phthalate Plasticizers in Hydra vulgaris : Acute Toxicity, Genotoxicity, Developmental and Behavioural Effects

Open DOI

Aditya Mohan Menon, Gayathri R. Chandran, Ramaswamy Babu Rajendran et al.

Phthalates pose significant risks to aquatic ecosystems, though their effects on nontarget organisms have been reported, with little information on Hydra. This study evaluated the developmental, cytotoxic and behavioural toxicity of four...

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03 18 October 2026

DOI 10.1002/jat.70485

Cytotoxic and Oxidative Effects of Common Pesticides on Hepatic and Renal Cell Lines (HepG2 and Hek‐293): Implications for Human Health and Environmental Safety

Open DOI

Fares Elghali, Kawther Bedchich, Nour Kacem et al.

Modern agricultural practices expose humans and the environment to numerous chemical pesticides. Increasing evidence suggests that commercial pesticide formulations may exhibit toxicological properties that differ from those of their act...

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04 18 October 2026

DOI 10.1002/jat.70477

Hemocyte, Biochemical, and Histopathological Responses of Biomphalaria alexandrina , the Egyptian Intermediate Host of Schistosoma mansoni , to Sublethal Deltamethrin Exposure

Open DOI

Rasha Ezzat Mohamed Ali, Rasha Mohamed Gad El‐Karim, Hassan El‐Sayed Flefel et al.

Deltamethrin is among the pyrethroids most frequently detected in Egyptian irrigation canals and drains, the same water bodies that support Biomphalaria alexandrina , the snail that transmits Schistosoma mansoni in Egypt. The objective o...

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05 16 October 2026

DOI 10.1002/jat.70464

Toxicity of Organophosphate Insecticides and Biochemical Mechanisms Associated With Resistance in Field Populations of Plutella xylostella (L.) From Kashmir, India

Open DOI

Bazila Rehman, Tariq Ahmad, Barkat Hussain

The diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae), is a globally important pest of cruciferous crops, for which intensive insecticide use has accelerated the evolution of resistance. However, the magnitude and bio...

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06 14 October 2026

DOI 10.1002/jat.70468

Assessment of Industrial Effluent‐Induced Multi‐Organ Toxicity, Genotoxicity, DNA Damage, and Esterase Activities Changes in the Brain, Liver, and Muscle of Oreochromis niloticus

Open DOI

Sarwat Ishaq, Ghazala Jabeen, Iqra Muzaffar et al.

Industrial effluents frequently contain a variety of toxic substances that can seriously threaten aquatic life. Pollutants discharged in industrial effluents can significantly induce genetic damage in aquatic organisms, leading to long‐t...

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07 14 October 2026

DOI 10.1002/jat.70478

Cardiac Histomorphometric Implications Resulting From Chronic Nandrolone Decanoate Treatment in Rats Subjected to Resistance Training

Open DOI

Lucas D. Ferreira, Tallys E. Velasco, Bruno A. Aguilar et al.

The effects of anabolic steroid abuse on the cardiac tissue of resistance training practitioners are poorly understood. Herein, we present the histomorphometric implications of resistance training in rats treated with nandrolone decanoat...

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08 13 October 2026

DOI 10.1002/jat.70472

Biochar‐nZVI Mediated Immobilization of Soil As and Cd Reduces Their Gastrointestinal Bioaccessibility and Cytotoxic Potential in Caco‐2/HL‐7702 Cells

Open DOI

Maria Aziz, Muhammad Tariq Rafiq, Ying Feng et al.

Soil‐bound arsenic (As) and cadmium (Cd) reach the human body through accidental ingestion, yet most risk assessments rely on total soil metal content rather than the fraction that is actually released and absorbed. The present study lin...

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09 13 October 2026

DOI 10.1002/jat.70476

Mixture Effects of Lead and Chromium in Zebrafish ( Danio rerio ) Brain: Involvement of Nrf2‐Keap1‐ARE Pathway

Open DOI

Olivia Sarkar, Sunanda Mukherjee, Tanmoy Das et al.

Lead (Pb) and chromium (Cr) are prevalent aquatic contaminants capable of inducing oxidative and neurological disturbances; however, the consequences of their combined exposure on brain oxidative homeostasis remain poorly understood. The...

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10 8 October 2026

DOI 10.1002/jat.70470

Europium Oxide Disrupts Metabolic Homeostasis and Antioxidant Defenses in African Catfish ( Clarias gariepinus ): Integrated Physiological and Molecular Docking Approaches

Open DOI

Abdallah Tageldein Mansour, Ahmed Saud Alsaqufi, Fatma Mahsoub et al.

Chemical pollution from rare earth elements (REEs) has emerged as a significant threat to the stability of freshwater ecosystems. Among these elements, europium oxide (Eu 2 O 3 ) is widely used across various industrial sectors; however,...

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