International journal of oral science

01 2 October 2026

DOI 10.1038/s41368-026-00465-0

H3K18la in periodontal ligament fibroblasts regulates immune niches and alveolar bone remodeling under mechanical loads

Open DOI

Bo Zhang, Zhihang Song, Yige Zhang et al.

02 29 September 2026

DOI 10.1038/s41368-026-00464-1

Spatially resolved single cell atlas deciphers SAA1 inflammatory epithelial cells

Open DOI

Yajie Wu, Zhifei Su, Bowen Zhang et al.

Disruption of epithelial integrity is a pivotal event in inflammation, disease pathogenesis, and tissue homeostasis. To investigate these processes in chronic inflammatory disease, we performed spatial transcriptomics integrated with sin...

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03 28 September 2026

DOI 10.1038/s41368-026-00466-z

RUNX2 promotes osteoclast differentiation and bone resorption via the newly identified LncRNA-ROD: implications for alveolar remodeling

Open DOI

Jie Li, Yang Liu, Yanchun Qiao et al.

Delayed tooth eruption is a hallmark of cleidocranial dysplasia (CCD) caused by RUNX2 haploinsufficiency, yet the underlying molecular mechanism remains undefined. Here, we show that RUNX2 regulates osteoclast-mediated alveolar bone remo...

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04 15 September 2026

DOI 10.1038/s41368-026-00463-2

IGFBP5 alleviates periodontitis by reversing human dental follicle stem cell senescence via the non-canonical Wnt pathway

Open DOI

Yuru Wang, Yue Wang, Yuguo Dai et al.

The improvement of health and the delay of aging represent pivotal goals in medical research. Bone aging contributes to various age-related disorders, including periodontitis. Dental follicle stem cells (DFSCs) serve as ideal seed cells ...

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05 14 September 2026

DOI 10.1038/s41368-026-00456-1

ID3-directed sonogenetics to enhance osteogenesis and bone defect healing

Open DOI

Huan Liu, Yifan Xu, Xue Wang et al.

Sonogenetics, a noninvasive approach combining ultrasound physics with genetic engineering, has shown clinical potential in promoting bone repair. However, its therapeutic efficacy remains suboptimal due to the scarcity of bone-specific ...

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06 10 September 2026

DOI 10.1038/s41368-026-00461-4

Piezo channels contribute to the terminal cytodifferentiation of odontoblasts via modulation of canonical Wnt signaling

Open DOI

Xuguang Nie, Kelley Huang, Emily Chu et al.

Piezo1 and Piezo2 are mechanosensitive ion channels that transduce mechanical stimuli into intracellular biochemical signals in diverse tissues and organ systems. Their functions in odontoblast development are still not well understood. ...

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07 31 August 2026

DOI 10.1038/s41368-026-00460-5

PFKM acts as a metabolic switch initiating donut-shaped mitochondrial remodeling to promote osteogenesis

Open DOI

Nengwen Huang, Yang Li, Jie Lu et al.

08 31 August 2026

DOI 10.1038/s41368-026-00462-3

Mechanical control in dental and jaw morphogenesis and remodeling

Open DOI

Xiangjun Yang, Xiaotian Zhang, Qingping Gao et al.

09 27 August 2026

DOI 10.1038/s41368-026-00458-z

Mechanobiology of orofacial tissues: principles, mechanisms, and therapeutic applications

Open DOI

Junnan Qi, Yawen Wang, Yuandong Xie et al.

10 25 August 2026

DOI 10.1038/s41368-026-00454-3

TLR9-engineered photoresponsive biomimetic nanodecoys for targeted NETs clearance to mitigate periodontitis-associated bone resorption

Open DOI

Siyan Liu, Yitong Liu, Yingyi Chen et al.