Immunogenetics

01 9 September 2026

DOI 10.1007/s00251-026-01413-2

Intra-colony divergence and global allele sharing reflect purifying selection and recombination at the Botryllus histocompatibility factor locus

Open DOI

Agniya M. Sokolova, Jacob Douek, Baruch Rinkevich

02 27 August 2026

DOI 10.1007/s00251-026-01412-3

Naïve adaptive immune receptor repertoires in celiac disease assessed by machine learning; impact of the HLA-DQ2.5 allotype on the TCR repertoire

Open DOI

Aengus Officer, Ida Lindeman, Milena Pavlovic et al.

The adaptive immune receptor repertoire (AIRR) - the collection of an individual’s B-cell and T-cell receptors (BCRs and TCRs, respectively) - encodes cumulative immune history and is shaped by both germline genetics and environmental ex...

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03 28 July 2026

DOI 10.1007/s00251-026-01409-y

Genetic association of immunosenescence to immune decline

Open DOI

Mohammad Y. Alshahrani, Zahraa AlKhafaje, Uday Abdul-Reda Hussein et al.

04 13 July 2026

DOI 10.1007/s00251-026-01411-4

Causal relationship and pathogenic mechanism analysis of breast cancer and coronary heart disease based on mendelian randomization and transcriptome data analysis

Open DOI

Mingbin Xie, Yuanhong Wu, Xinyao Jin et al.

Breast cancer (BC) is closely linked to coronary heart disease (CHD), yet the genetic causal relationship and common driving mechanism between the two have not been fully elucidated. The purpose of this study is to infer the causal relat...

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05 6 July 2026

DOI 10.1007/s00251-026-01407-0

Genotype–phenotype correlations in autoimmune and autoinflammatory diseases: An NGS-based immunogenetic cohort study

Open DOI

Esra Çolak Geniş, Fethi Sırrı Çam

ObjectiveAutoimmune and autoinflammatory diseases (AIDs) represent a heterogeneous group of immune-mediated disorders characterized by dysregulated innate and adaptive immune responses. This study aimed to investigate the immunogenetic b...

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06 6 July 2026

DOI 10.1007/s00251-026-01410-5

Elevated interleukin-36γ and gene polymorphisms implicate novel risk in essential hypertension

Open DOI

Alishba Kainat, Fazlul Aziz Mian, Muhammad Asif Nawaz Khan et al.

Cytokines are crucial in regulating hypertension and vascular inflammation. The clinical significance of circulating IL-36γ levels and IL36G gene variants in relation to essential hypertension risk was assessed because IL-36γ has been as...

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07 4 July 2026

DOI 10.1007/s00251-026-01408-z

Unraveling the genomic structures, conserved functional domains and evolutionary dynamics of beta-defensins in Bubalus bubalis and Ovis aries

Open DOI

Sonam Yadav, Chanchal Rana, Fanny Josan et al.

Defensins are key innate immune proteins exhibiting pleiotropic functions such as antibacterial activity, antiviral activity, anti-inflammatory activity, immunomodulatory functions, and roles in reproduction. Genomic information inadequa...

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08 27 June 2026

DOI 10.1007/s00251-026-01406-1

Genetic characterization of the TAPBP and its allelic association with BF2 in the chicken major histocompatibility complex

Open DOI

Roshani Fernando, Trisha Nicole Agulto, Eunjin Cho et al.

TAPBP is a key chaperone of the peptide-loading complex that facilitates peptide loading onto major histocompatibility complex class I (MHC I) molecules. This study characterized TAPBP alleles in Korean Native Chickens (KNCs), identified...

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09 19 June 2026

DOI 10.1007/s00251-026-01404-3

Reconstructed amphibian heavy-chain constant regions support a mosaic origin of IgXA with IgY-like CH1–CH2, an intermediate CH3, and an IgM-like CH4

Open DOI

Francisco Gambón-Deza

The evolutionary relationship between amphibian IgM, IgY, and IgX/A-like antibodies has remained difficult to resolve, largely because repetitive heavy-chain loci are often incompletely or inconsistently annotated. In this study, I re-an...

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10 18 June 2026

DOI 10.1007/s00251-026-01405-2

Climate factors and selection shape MHC class II diversity in a montane wild sheep (Ovis ammon)

Open DOI

Zi-Yue Tian, Jin-Yi Li, Zhen-Yuan Cai et al.

Understanding how environmental heterogeneity drives spatially varying selection is key to deciphering adaptive evolution. The Major Histocompatibility Complex (MHC) provides an ideal model to study this process. We investigated the MHC ...

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