Fluids and barriers of the CNS

01 17 October 2026

DOI 10.1186/s12987-026-00889-0

Neonatal diphtheria toxin treatment of iDTR mice reduces ventricular volume and shows damage in the choroid plexus in an age-dependent manner

Open DOI

Paloma Merchan-Sala, Zohair Siddiqui, Stephanie A. Stephens et al.

The choroid plexus (ChP), which is located in the cerebral ventricles, is the principal source of cerebrospinal fluid (CSF), contributing to approximately 80% of its production. Dysregulation of CSF volume results in neonatal hydrocephal...

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02 15 October 2026

DOI 10.1186/s12987-026-00888-1

FOSB and JUND transcription factors induce ABCB1 expression and regulate transport in human pluripotent stem cell-derived endothelial cells

Open DOI

Soniya Tamhankar, Yunfeng Ding, Vijay Mukesh Parmar et al.

03 14 October 2026

DOI 10.1186/s12987-026-00890-7

Blood-brain barrier dysfunction and altered choroid plexus contrast kinetics in Parkinson’s disease

Open DOI

Sapir Fajerzstein, Gadi Maayan Eshed, Sheida Mirloo et al.

Background: Neurovascular dysfunction may contribute to Parkinson’s disease (PD), but the extent and clinical relevance of blood-brain barrier alterations remain uncertain. We investigated regional blood-brain barrier permeability, fract...

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04 8 October 2026

DOI 10.1186/s12987-026-00883-6

Elevated apparent diffusion coefficient of extra-axial space in patients with traumatic brain injury

Open DOI

Nicole L. Peterkin, Sophia Z. Cheng, Marie L. Luby et al.

Background: Following traumatic brain injury, the apparent diffusion coefficient (ADC) of fluid within extra-axial space was discovered to be elevated above that of water in “free space”. We aimed to characterize the prevalence, predicto...

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05 8 October 2026

DOI 10.1186/s12987-026-00887-2

Mitochondrial transfer and transplantation as emerging neurotherapeutic strategies for central nervous system disorders

Open DOI

Jingyi Li, Mingfu Zhang, Shiping Li et al.

06 7 October 2026

DOI 10.1186/s12987-026-00885-4

Transport of FGF21 across the blood-brain barrier: mechanisms and receptor activation

Open DOI

Sabrine Linhares, Manon Leclerc, Josue Valentin-Escalera et al.

07 29 September 2026

DOI 10.1186/s12987-026-00882-7

Ablation of the choroid plexus attenuates hydrocephalus-induced parenchymal edema with moderate reduction of postnatal hippocampal neurogenesis

Open DOI

Aleksandr Taranov, Florian Mayrhofer, Sage Hamm et al.

08 29 September 2026

DOI 10.1186/s12987-026-00886-3

Intrathecal mesenchymal stem cell therapy in progressive multiple sclerosis: integrated blood and CSF profiling in the SMART-MS randomized trial

Open DOI

Dimitrios Kleftogiannis, Sonia Gavasso, Live Egeland Eidem et al.

Therapeutic options for progressive multiple sclerosis (MS) remain limited, and the mechanisms engaged by intrathecal mesenchymal stem cell (MSC) therapy are incompletely understood. MSCs are proposed to exert immunomodulatory and trophi...

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09 28 September 2026

DOI 10.1186/s12987-026-00881-8

Comparative analysis of regional blood–brain barrier permeability in humans and rodents: implications for functional specialization and aging

Open DOI

Sheida Mirloo, Lyna Kamintsky, Shayna Cort-Samuel et al.

Background: The blood-brain barrier (BBB) serves a critical function in regulating transport between the blood and the brain, with its dysfunction being implicated in numerous neurological diseases such as neurodegenerative disorders, ep...

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10 24 September 2026

DOI 10.1186/s12987-026-00860-z

Establishment of an in vitro human blood-brain barrier model for antiviral screening against neurotropic viruses

Open DOI

Marisol Zuniga, Alexander Herrmann, Matteo Rizzato et al.

Background: Neurotropic viruses infect the central nervous system (CNS) resulting in severe neurological and long-term complications, including permanent cognitive impairments. However, for many of these neurotropic viruses, like tick-bo...

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