Experimental & molecular medicine

01 16 October 2026

DOI 10.1038/s12276-026-01876-z

Platelet-derived microparticles induce CD8+ T cell senescence in chronic kidney disease via the transfer of microRNA-550a-5p

Open DOI

Yuewen Sun, Qigang Lan, Yaqin Wang et al.

Infection is a leading cause of mortality in patients with chronic kidney disease (CKD), in which T cell dysfunction is considered a typical feature. Although platelets are active participants in immune response, their role in regulating...

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02 16 October 2026

DOI 10.1038/s12276-026-01870-5

Cardiomyocyte-enriched OTUD5 alleviates pathological myocardial hypertrophy by deubiquitinating STAT3 and modulating the STAT3–PGC-1α axis

Open DOI

Bozhi Ye, Yucheng Jiang, Zhaozheng Zheng et al.

Pathological cardiac hypertrophy presents a important public health challenge, particularly in aging populations, highlighting the urgent need for novel therapeutic targets. This study investigates the role and molecular mechanisms of OT...

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03 14 October 2026

DOI 10.1038/s12276-026-01868-z

Decreased circulating dopamine β-hydroxylase is associated with medication-related osteonecrosis of the jaw and implicates sympathetic dysregulation

Open DOI

Kyeongho Lee, Hana Cho, June Yeon Kim et al.

Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication of antiresorptive therapy, yet no reliable circulating biomarker exists for risk stratification. Using an unbiased serum proteomics approach in a multicentre fr...

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04 13 October 2026

DOI 10.1038/s12276-026-01866-1

Translational modelling of human microglia from cultures to chimeras

Open DOI

Jina Lee, Yongjin Yoo

Microglia play a crucial role in maintaining homeostasis of the central nervous system, whereas their dysfunction is implicated in the pathogenesis of various neurological diseases. Nevertheless, interspecific genetic differences pose ch...

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05 9 October 2026

DOI 10.1038/s12276-026-01831-y

Microbial cues and T cell immunity: deciphering their interactions in chronic liver disease

Open DOI

Yinuo Liu, Baichao Yu, Qiaoyan Liu et al.

Chronic liver disease (CLD) poses a major global health challenge, as its progression to cirrhosis and hepatocellular carcinoma significantly contributes to worldwide morbidity and mortality. Mounting evidence has identified the gut micr...

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06 9 October 2026

DOI 10.1038/s12276-026-01860-7

PET imaging enables direct evaluation of ferroptosis in HCC synergistically induced by anti-PD-L1 and Olaparib

Open DOI

Feng Xiong, Cheng Xu, Pei Wang et al.

The efficacy of PET image-guided immune checkpoint inhibitor-based therapy in hepatocellular carcinoma (HCC) management is limited by the lack of direct monitoring of therapeutic response. A key challenge is the mismatch between the ther...

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07 9 October 2026

DOI 10.1038/s12276-026-01867-0

SLC4A9 deficiency is involved in Sjögren’s syndrome and enamel defects through RPS27-triggered ribosomal stress

Open DOI

Wenyan Ruan, Jing Dong, Yali Xu et al.

Xerostomia, a salivary gland disorder affecting up to 30% of adults, compromises oral homeostasis by reducing salivary flow and buffering capacity. Amelogenesis imperfecta is a hereditary condition characterized by defective enamel forma...

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08 7 October 2026

DOI 10.1038/s12276-026-01862-5

Insulin mimetics and non-canonical insulin receptor signaling: mechanisms and disease relevance

Open DOI

Junhee Park, Eunhee Choi

Insulin receptor (IR) signaling has traditionally been viewed as a canonical pathway in which insulin binding uniformly activates downstream metabolic and mitogenic responses. However, growing evidence indicates that IR signaling is not ...

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09 7 October 2026

DOI 10.1038/s12276-026-01869-y

Cell plasticity in cancer and therapy resistance

Open DOI

Yoojeong Seo, Jinho Jang, Jae-Il Park

Cancer cell plasticity, the ability of tumor cells to switch between distinct cellular states, has emerged as a key mechanism driving tumor progression, metastasis and therapy resistance. Cancer cells exploit diverse plasticity mechanism...

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10 7 October 2026

DOI 10.1038/s12276-026-01864-3

Macrophage pyroptosis drives luminal senescence and club-cell reprogramming in 5α-reductase inhibitor-treated prostatic hyperplasia

Open DOI

Zheng Li, Zhenan Zhang, Qiancheng Zhao et al.

Benign prostatic hyperplasia (BPH) is a common age-associated disease whose prevalence rises sharply with advancing age. Therapeutic responses to 5α-reductase inhibitors (5-ARIs) in BPH are heterogeneous and may ultimately culminate in t...

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