Endocrine pathology

01 19 October 2026

DOI 10.1007/s12022-026-09937-9

Correction to: Comprehensive Genomic Analysis in Hereditary Adrenal and Extra- Adrenal Paragangliomas

Open DOI

Helia Purnaghshband, Elif Tuzlali, Kamalika Bhandari Deka et al.

02 9 October 2026

DOI 10.1007/s12022-026-09936-w

Distinct Molecular Pathways Driving Thymic and Pulmonary Neuroendocrine Neoplasms: Organ of Origin Defines Molecular Identity and Yields CD44 as a Marker of Pulmonary Neuroendocrine Tumors

Open DOI

Hanibal Bohnenberger, Stefan Küffer, Arber Qoku et al.

Thymic and pulmonary neuroendocrine neoplasms (NEN) are morphologically similar but arise from different embryonic tissues. Whether this similarity extends to shared molecular programs is unclear. We compared 45 thymic and 37 pulmonary N...

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03 12 September 2026

DOI 10.1007/s12022-026-09935-x

Divergent c-MYC Expression Patterns in NET and NEC: Insights from a Multicentre Cohort of 1380 Neuroendocrine Neoplasms

Open DOI

Maxime Schmitt, Katharina Ofner, Detlef Klaus Bartsch et al.

Neuroendocrine neoplasms (NEN) comprise well-differentiated neuroendocrine tumours (NET) and neuroendocrine carcinomas (NEC), whose distinction is clinically critical. Although c-MYC alterations have been implicated in NEC pathogenesis, ...

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04 12 September 2026

DOI 10.1007/s12022-026-09934-y

Comprehensive Clinicopathologic, Immunohistochemical, and Genomic Profiling of Sporadic Ampullary Somatostatin-producing D-cell Neuroendocrine Tumors Identifies Recurrent HRAS Hotspot Mutations

Open DOI

Alessandro Vanoli, Erica Travaglino, Frediano Inzani et al.

Ampullary somatostatin-producing D-cell neuroendocrine tumors are rare neoplasms that may be associated with type 1 neurofibromatosis. The molecular features of sporadic ampullary somatostatin-producing D-cell neuroendocrine tumors (SAMS...

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05 29 August 2026

DOI 10.1007/s12022-026-09933-z

Real-World-Feasible Immunohistochemistry of ATRX, DAXX, and Menin Identifies a Subgroup of Non-Functioning Pancreatic Neuroendocrine Tumors with low Recurrence Risk to Guide De-Escalating Surveillance

Open DOI

Anna Vera Ditte Verschuur, Wenzel Maximillian Hackeng, Jasvir Jairam et al.

Non-functioning pancreatic neuroendocrine tumors (NF-pNETs) show a variable prognosis. Despite 40–60% of patients remaining recurrence-free after surgery, guidelines recommend ≥ 10 years of follow-up. Recent studies identify prognostic s...

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06 25 August 2026

DOI 10.1007/s12022-026-09932-0

Neuroendocrine Neoplasms of the Urinary Bladder: Integrating Molecular Advances into a Refined Classification System

Open DOI

Anandi Lobo, Liang Cheng

Neuroendocrine neoplasms (NENs) of the urinary bladder are rare but highly aggressive tumors that account for under 1% of bladder malignancies. The 2022 WHO classification recognizes small cell neuroendocrine carcinoma (SCNEC), large cel...

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07 24 August 2026

DOI 10.1007/s12022-026-09930-2

Comprehensive Genomic Analysis in Hereditary Adrenal and Extra-Adrenal Paragangliomas

Open DOI

Helia Purnaghshband, Elif Tuzlali, Kamalika Bhandari Deka et al.

Adrenal and extra-adrenal paragangliomas (PPGLs) are highly heritable non-epithelial neuroendocrine neoplasms. Through a retrospective chart review of 110 individuals diagnosed with PPGLs at the University Health Network in Toronto, Cana...

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08 22 August 2026

DOI 10.1007/s12022-026-09931-1

Tumor Necrosis is Associated with an Increased Metastatic and Cardiovascular Risk in Paragangliomas: A Single-Center Series and Meta-Analysis Comparing Necrosis and Cystic Degeneration in Paragangliomas

Open DOI

Anna-Maria Wiejak, Georgiana Constantinescu, Gintare Zygiene et al.

Paragangliomas (PGLs) are rare neural crest–derived tumors with highly variable morphology and clinical behavior. These tumors can present with cystic and necrotic alterations that may influence the clinical presentation of affected pati...

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09 28 July 2026

DOI 10.1007/s12022-026-09929-9

A Cauda Equina Neuroendocrine Tumor with Tyrosine Hydroxylase Expression

Open DOI

Knarik Arkun, Zahra Jalali, Mina G. Safain et al.

10 22 July 2026

DOI 10.1007/s12022-026-09928-w

Expansion of Germline Variants in Primary Hyperparathyroidism: Fumarate Hydratase Deficiency as a Cause of Parathyroid Adenomas

Open DOI

Hussam Alkaissi, Elias Chuki, Yi Liu et al.

A substantial fraction (60–85%) of hereditary primary hyperparathyroidism (hPHPT) lacks an identifiable genetic etiology. We describe fumarate hydratase ( FH ) mutations as a potential cause of hPHPT, expanding the phenotypic spectrum of...

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