Drug metabolism and pharmacokinetics

01 9 October 2026

DOI 10.1016/j.dmpk.2026.101555

Theoretical Analysis of Developmental Changes in Adenosine A2A Receptor Occupancy in Premature Infants Under Caffeine Therapy

Open DOI

Haruka Ide, Akane Hara, Ryosuke Fujihara et al.

02 6 October 2026

DOI 10.1016/j.dmpk.2026.101556

Microsomal and Hepatocyte Binding in Drug Discovery: Method Suitability and Lipophilicity-Based Predictions

Open DOI

Leonel Torrão, Gaëlle Chenal, Stephane Rodde et al.

03 3 October 2026

DOI 10.1016/j.dmpk.2026.101552

Evaluation of Food Effects on Oral Absorption from Lipid-Based Formulations Using an In Vitro Digestion–In Situ Absorption Model with a Physiologically Relevant Surface Area to Volume Ratio

Open DOI

Yusuke Tanaka, Shogo Sasaki, Hiroto Nishiura et al.

04 29 September 2026

DOI 10.1016/j.dmpk.2026.101553

Beyond Km and Vmax: a geometric framework for characterising enzyme modulation and validating kinetic data

Open DOI

Jonathan Salerno

05 28 September 2026

DOI 10.1016/j.dmpk.2026.101554

Translational limitations of a rat-derived hybrid pharmacokinetic–toxicodynamic model for chemotherapy-induced hematologic toxicity in humans

Open DOI

Shinji Kobuchi, Kenji Ikemura, Akihide Kobayashi et al.

06 15 September 2026

DOI 10.1016/j.dmpk.2026.101551

Assessment of Infliximab Biotransformation in Patient Serum by Comparing Mass-Spectrometry and Ligand-Binding Assay Quantification

Open DOI

Sho Masui, Aoto Nakajima, Kodai Yajima et al.

07 17 July 2026

DOI 10.1016/j.dmpk.2026.101549

Population pharmacokinetic analysis and exposure–response analysis of brexpiprazole in Japanese patients with agitation in Alzheimer's dementia

Open DOI

Koushi Higashi, Tomohiro Sasaki, Hikari Takahashi et al.

08 15 July 2026

DOI 10.1016/j.dmpk.2026.101550

Characterization of unusual pyrazole ring-rearranged metabolites of DS-1971a specific to monkeys

Open DOI

Daigo Asano, Kazuyoshi Michiba, Kayoko Masuda et al.

09 30 June 2026

DOI 10.1016/j.dmpk.2026.101546

Development of a Method for Vancomycin Monitoring in Interstitial Fluid Using a Novel Porous Microneedle Array Patch

Open DOI

Jo Terauchi, Taisei Kawamura, Jongho Park et al.

10 29 June 2026

DOI 10.1016/j.dmpk.2026.101547

β-Cyclodextrin as a Negative Allosteric Modulator of Mammea A/AA Binding to Serum Albumin: A Spectroscopic and Molecular Dynamics Study

Open DOI

Ateba A. Baruch, Mathieu J.M. Tjegbe, Loveline T. Bamou et al.