Drug metabolism and disposition : the biological fate of chemicals

01 13 October 2026

DOI 10.1016/j.dmd.2026.100422

Systematic Evaluation of Organoid Fidelity for ADME and Toxicity Assessment

Open DOI

Ruoxuan Xiao, Yuwei Zheng, Shuya Huang et al.

02 10 October 2026

DOI 10.1016/j.dmd.2026.100420

The Relationship Between Age and Endogenous Biomarkers of Organic Anion Transporters 1 and 3 (OAT1/3) in Preterm Neonates: A Cross-sectional Study

Open DOI

Mohamed Y. Abdelgaied, Cheri Gauldin, William Truog et al.

03 10 October 2026

DOI 10.1016/j.dmd.2026.100419

Evaluation of a Long-Term Human Hepatocyte Culture Maintained in PowerHEP Maintenance Medium for Drug Clearance Prediction

Open DOI

Qianying Yuan, Mitchell Laughlin, Xiaofeng Wu et al.

04 8 October 2026

DOI 10.1016/j.dmd.2026.100416

Multidimensional Regulation of the Cytochrome P450 Metabolic Network in Pulmonary Arterial Hypertension: Homeostatic Imbalance, Pathological Drivers, and Environmental Interactions

Open DOI

Fengxue Zhou, Yu Ma, Tao Zhang et al.

05 8 October 2026

DOI 10.1016/j.dmd.2026.100417

Absorption, distribution, metabolism, excretion, and pharmacokinetics of remibrutinib, an oral, highly selective, Bruton’s tyrosine kinase inhibitor, in healthy participants at steady state

Open DOI

Alexander David James, Frederic Lozac’H, Melissa Hackling et al.

06 7 October 2026

DOI 10.1016/j.dmd.2026.100415

In Vitro-In Vivo Extrapolation of Hepatic Clearance for GalNAc-siRNA Therapeutics Using Rat Liver Tritosomes

Open DOI

Harvey Andersen, Alec Bell, Ryan Hill et al.

07 29 September 2026

DOI 10.1016/j.dmd.2026.100413

A Previously Undetected Major Circulating Metabolite of Trazpiroben Revealed by Human Radiolabeled Absorption, Distribution, Metabolism, and Excretion Study

Open DOI

Sean Xiaochun Zhu, Mitsuhiro Nishihara, Diane Ramsden et al.

08 29 September 2026

DOI 10.1016/j.dmd.2026.100412

EVALUATION OF DEUTERIUM ISOTOPE EFFECTS ON THE METABOLISM OF TEN DRUGS ACROSS MULTIPLE HUMAN CYTOCHROME P450 ENZYMES: CONSIDERATIONS FOR DRUG DESIGN

Open DOI

R. Scott Obach, Matthew A. Cerny

09 29 September 2026

DOI 10.1016/j.dmd.2026.100414

Monocarboxylate transporter 6 mediates sex-dependent cisplatin ototoxicity via metabolite uptake

Open DOI

Arthur Germakovski, Mengxiao Ye, Vivian Xu et al.

10 17 September 2026

DOI 10.1016/j.dmd.2026.100411

Impact of nonspecific binding to membrane vesicles on unbound IC50 estimation for P-glycoprotein and breast cancer resistance protein inhibitors and implications for drug-drug interaction risk assessment

Open DOI

Renjie Zhan, Richard Moulton, Scott Tallman et al.