Drug development research

01 11 October 2026

DOI 10.1002/ddr.70393

Correction to “Mesalamine in Treatment of Intestinal Inflammatory Diseases—Formulation‐Driven Strategies for Targeted Colonic Therapy and Remission Maintenance”

Open DOI

02 9 October 2026

DOI 10.1002/ddr.70394

Bavachin Attenuates Cognitive Impairment in Scopolamine‐Induced Amnesia: Behavioral, Biochemical and Molecular Insights

Open DOI

Md. Shadin, Monisha Brati Barua, Talat Ali et al.

Cholinergic dysfunction is a key feature of cognitive impairment, and currently available acetylcholinesterase (AChE) inhibitors provide limited symptomatic benefit and are often associated with adverse effects. This study evaluated the ...

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03 23 September 2026

DOI 10.1002/ddr.70392

Comprehensive Evaluation of Gastrointestinal Factors Influencing the Stability and Function of mRNA‐Encapsulated Lipid Nanoparticles

Open DOI

Toma Shinkai, Koki Ogawa, Mohamed S. Mohamed et al.

Owing to the intrinsic instability of mRNA, its routes of administration are limited, and to date, only injectable delivery has been clinically applied. In contrast, oral administration exposes mRNA to a variety of substances in the gast...

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04 22 September 2026

DOI 10.1002/ddr.70391

Sphingosine‐1‐Phosphate Attenuates LPS‐Induced Inflammatory Cardiac Injury in Association With RASGRP1–S100A9–NLRP3 Signaling

Open DOI

Chaofu Yue, Qiaolin Li, Chunyan Li et al.

Lipopolysaccharide (LPS) induces endotoxemia‐associated inflammatory cardiac injury rather than classical viral or autoimmune myocarditis. Sphingosine‐1‐phosphate (S1P) regulates cardiovascular and immune responses, predominantly through...

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05 22 September 2026

DOI 10.1002/ddr.70389

Molecular Design and Anticancer Activities of Small‐Molecule BRAF Inhibitors: A Medicinal Chemistry Perspective

Open DOI

Shuyu Jia, Jieman Lin, Janjun Wu et al.

BRAF is a cytoplasmic serine‐threonine protein kinase that plays a critical role in the MAPK signaling pathway. BRAF is the only member of the RAF family activated by mutation in human cancers. Many classes of B‐Raf small molecule inhibi...

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06 20 September 2026

DOI 10.1002/ddr.70388

Statins as Repurposed Anticancer Agents: Regulated Cell Death, the Tumor Immune Microenvironment, and the Translational Evidence Gap

Open DOI

Xu Zhou, Yizhang Chen, Hanxiao Hua et al.

Statins inhibit 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR) and reduce flux through the mevalonate pathway, which supplies both cholesterol and the non‐sterol isoprenoids required for prenylation of small GTPases. Because thi...

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07 18 September 2026

DOI 10.1002/ddr.70390

Comparative Evaluation of Plumbagin and Sorafenib in NDEA–TAA‐Induced Hepatocellular Carcinoma: Effects on Hepatic Function, Redox Homeostasis and Histopathology

Open DOI

Akinade K. Adetola, Regina N. Ugbaja, Olubisi E. Adeyi et al.

Hepatocellular carcinoma (HCC) is a major contributor to cancer‐related mortality worldwide and is closely linked to oxidative stress and progressive hepatic dysfunction. This study investigated the effects of plumbagin on antioxidant de...

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08 17 September 2026

DOI 10.1002/ddr.70387

Gypenosides Damulin A and Damulin B Inhibit Hepatocellular Carcinoma by Regulating Cholesterol Synthesis

Open DOI

Fang‐Fang Li, Can Cui, Zhou‐Juan Zheng et al.

Hepatocellular carcinoma (HCC) is a common malignant tumor of the digestive system. The liver is the primary organ for cholesterol production and metabolism in the body. Abnormal cholesterol levels can promote the initiation and progress...

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09 16 September 2026

DOI 10.1002/ddr.70381

Advances in N ‐ and S ‐Heterocycles as c‐Jun‐N‐Terminal Kinase 3 Inhibitors for Alzheimer's Disease Treatment

Open DOI

Parul Yadav, Deepak Mishra, Ram Singh

C‐Jun‐N‐terminal kinase 3 (JNK3) inhibitors are emerging as promising therapeutic agents for the treatment of Alzheimer's disease (AD). Predominantly expressed in the central nervous system (CNS), JNK3 plays a crucial role in neuronal ap...

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10 16 September 2026

DOI 10.1002/ddr.70384

Synthesis of Tetrahydro‐β‐Carboline‐Based Spirocyclic Peptides via Cascade N ‐Boc Deprotection and Pictet‐Spengler Reaction of Tryptophan: Potent Anti‐Inflammatory and Anti‐Oxidant Activities

Open DOI

Shravani Battula, Vaishnavi Kambhampati, Sai Balaji Andugulapati et al.

Inflammation is a tightly regulated response that maintains tissue homeostasis; however, its dysregulation in the lung contributes to acute lung injury (ALI), characterised by excessive cytokine production, oxidative stress, epithelial‐e...

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