Disease models & mechanisms

01 19 October 2026

DOI 10.1242/dmm.053163

Comprehensive cardiac, vascular, and pulmonary characterization of a cardiometabolic HFpEF model

Open DOI

Ibrahim Aykac, Christoph A. Baumgartner, Ouafa Hamza et al.

Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome in which translational progress is limited by experimental models that insufficiently reflect the cardiometabolic phenotype while affecting en...

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02 19 October 2026

DOI 10.1242/dmm.053052

Single-cell atlas of neuroma-induced DRG remodeling reveals intervention-specific glial and immune programs

Open DOI

Casey L. Stewart, Michael M. Morris, Alexandra E. Halevi et al.

Peripheral nerve injury caused by cut, crush, or excessive stretch can lead to disordered regeneration and painful neuroma formation. Regrowing axons may terminate in a swollen, hypersensitive nerve stump, producing pain that can outweig...

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03 9 October 2026

DOI 10.1242/dmm.052994

Distinct biological and biomechanical features in jaw and knee cartilage contribute to their degenerative susceptibility

Open DOI

Jingyu He, Hong Colleen Feng, Junxi Guo et al.

The temporomandibular joint (TMJ) and knee joint are both prone to degenerative diseases such as osteoarthritis (OA); however, TMJ-OA generally manifests earlier than knee OA, with underlying mechanisms largely unknown. In this study, we...

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04 6 October 2026

DOI 10.1242/dmm.052484

Loss of transcriptional factor Zbtb33 fails to induce clonal hematopoiesis in mice but plays a role in tumor growth

Open DOI

Yuhang Li, Kaiping Luo, Keyao Xia et al.

Clonal hematopoiesis (CH) is an early indicator of hematologic malignancies, driven by mutations in hematopoietic stem cells (HSCs) such as TET2 or P53. Recently ZBTB33 mutations have been implicated in myelodysplastic syndromes (MDS) an...

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05 1 October 2026

DOI 10.1242/dmm.053219

First person – Jenna Villman

Open DOI

First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Jenna Villman is first author on ‘ Pharmacoki...

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06 1 October 2026

DOI 10.1242/dmm.052907

Pharmacokinetics and efficacy of tank-water-administered dabrafenib, a BRAF inhibitor, in a zebrafish model of melanoma

Open DOI

Jenna Villman, Nikol Dibus, Jonas Huhn et al.

Zebrafish models are widely used to study BRAF-mutant melanoma biology. However, long-term treatment of adult fish with small-molecule BRAF inhibitors remains challenging, and pharmacokinetic data to inform rational dosing strategies are...

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07 1 October 2026

DOI 10.1242/dmm.052963

Dysregulated microRNA–mRNA networks in SOD1G93A skeletal muscle reveal metabolic impairments in amyotrophic lateral sclerosis

Open DOI

Libby Moody, Eleni Christoforidou, Greig Joilin et al.

Amyotrophic lateral sclerosis (ALS) is a multi-system disease in which skeletal muscle actively contributes to pathology, yet the regulatory circuits that drive muscle dysfunction remain unclear. We examined miRNA–mRNA interactions in th...

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08 1 October 2026

DOI 10.1242/dmm.052775

A patient-derived missense mouse model of Kabuki syndrome 1

Open DOI

Sara Tholl Halldorsdottir, Meghna Vinod, Hilmar Orn Gunnlaugsson et al.

Kabuki syndrome type 1 (KS1) is a rare cause of intellectual disability resulting from heterozygous pathogenic variants in the gene encoding the histone methyltransferase KMT2D. A previously established loss-of-function mouse model of KS...

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09 18 September 2026

DOI 10.1242/dmm.053030

Cognitive flexibility deficits differ between the sexes in a transchromosomic mouse model of Down syndrome

Open DOI

Elysabeth Otte, Nicole Gordon, Andrew Folz et al.

Individuals with Down syndrome (DS) exhibit cognitive and behavioral phenotypes, including intellectual disability, and reduced cognitive flexibility. The TcMAC21 DS mouse model (Tc(HSA21,CAG-EGFP)1Yakaz/J) has a freely segregating human...

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10 1 September 2026

DOI 10.1242/dmm.052804

Advances in diagnosis of mitochondrial dysfunction and primary mitochondrial disease

Open DOI

Melis Kose, Elizabeth McCormick, James T. Peterson et al.

Mitochondria are critical cellular organelles engaged in energy production, diverse intermediary metabolic functions and signaling. Inherited genetic disorders directly affecting mitochondrial structure and/or function, known collectivel...

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