Digestion

01 16 October 2026

DOI 10.1159/dig/acmag017

Guidelines for Colonic Diverticular Disease—2026, Second Edition: Management of Diverticular Bleeding and Acute Diverticulitis

Open DOI

Chikamasa Ichita, Naoyoshi Nagata, Tomonori Aoki et al.

Colonic diverticular disease is becoming increasingly common in Japan, paralleling population aging and changes in lifestyle and medication use. The predominance of right-sided diverticulosis in Asian populations, in contrast to the left...

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02 15 October 2026

DOI 10.1159/dig/acmag013

A Structured, Repetitive Simulation Program for Endoscopic Coagulation Hemostasis with Hemostatic Forceps: An Assessor-Blinded Randomized Controlled Trial Using a Bleeding Ulcer Model

Open DOI

Suguo Suzuki, Takeshi Kanno, Yutaka Hatayama et al.

Introduction Prompt endoscopic hemostasis is required to control upper gastrointestinal bleeding. Current training relies on on-the-job exposure, with limited evidence supporting the use of dry-lab simulators. This study aimed to develop...

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03 9 October 2026

DOI 10.1159/dig/acmag030

Ultrathin endoscope-assisted pancreatobiliary interventions: from direct transpapillary access to created access routes

Open DOI

Tadahisa Inoue, Masanao Nakamura, Kiyoaki Ito

Background: ERCP is the standard endoscopic approach for pancreatobiliary diseases, but it relies mainly on fluoroscopic assessment and cannot provide direct intraductal visualization. Ultrathin upper gastrointestinal endoscopes, origina...

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04 8 October 2026

DOI 10.1159/dig/acmag001

Color Features on Linked Color Imaging and Histology of Early Gastric Cancer in Previously Helicobacter pylori-Infected Stomachs

Open DOI

Masayuki Higashino, Shoko Ono, Noriyuki Otsuka et al.

Introduction: Linked color imaging (LCI) enhances subtle mucosal color differences and may facilitate the detection of early gastric cancer (EGC), particularly in Helicobacter pylori (H. pylori)-eradicated stomachs. However, the histolog...

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05 7 October 2026

DOI 10.1159/dig/acmag027

Prevalence and burden of functional dyspepsia and “gastroparesis-like” symptoms in a primary care diabetes population

Open DOI

Heithem Soliman, I-Hsuan Huang, Hamid Ferdosi et al.

Introduction: The prevalence of gastroparesis (GP) and functional dyspepsia (FD) in diabetes remains unknown. Nausea and/or vomiting are now considered cardinal symptoms for GP, defining the “gastroparesis-like symptoms” (GPLS). We aimed...

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06 5 October 2026

DOI 10.1159/dig/acmag026

Endoscopic Treatment for Pancreatobiliary Diseases in Patients with Surgically Altered Anatomy: A Perspective from Double-Balloon Endoscopy

Open DOI

Haruka Toyonaga, Makoto Masaki, Shintaro Yodozawa et al.

Background: The number of patients with surgically altered anatomy (SAA) is increasing worldwide. In these patients, pancreatobiliary disease is difficult to treat, because a conventional duodenoscope cannot reach the papilla or the bili...

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07 5 October 2026

DOI 10.1159/dig/acmag022

Dual Therapy with Tacrolimus and Infliximab for Patients with Refractory Ulcerative Colitis

Open DOI

Naokuni Sakiyama, Ryosuke Yamaguchi, Kazuki Kakimoto et al.

Background: In refractory cases of ulcerative colitis (UC) where tacrolimus treatment is ineffective, colectomy is often required. This study aimed to evaluate the efficacy and safety of dual therapy with tacrolimus and infliximab. We al...

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08 30 September 2026

DOI 10.1159/dig/acmag019

Factors associated with all-cause mortality in Gastroesophageal Carcinoma in Situ: Nationwide Cohort Study

Open DOI

Su Youn Nam, Junwoo Jo, Sung Kook Kim

Background: The prognosis of esophageal and gastric carcinoma in situ (CIS) is excellent but population-level incidence pattern and mortality determinants remain limited. Methods: We conducted a nationwide study using Korea Healthcare Bi...

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09 29 September 2026

DOI 10.1159/dig/acmag024

Upadacitinib for Acute Severe Ulcerative Colitis: Real-World Tertiary Care Outcomes

Open DOI

Fares Jamal, Alejandro J Gonzalez, Sandra Elmasry et al.

Background Acute severe ulcerative colitis (ASUC) affects up to 25% of patients with ulcerative colitis. Despite intravenous (IV) corticosteroids as first-line therapy, 30–40% require rescue treatment and up to 40% undergo colectomy with...

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10 29 September 2026

DOI 10.1159/dig/acmag018

AI-generated guidance for non-specialist physicians managing inflammatory bowel disease: expert evaluation and case-based testing of GPT-4 and DeepSeek

Open DOI

Yan Liu, Chaoqun Hu, Xiaomei Song et al.

Introduction: Shortages of inflammatory bowel disease (IBD) specialists, particularly in China and other resource‑constrained settings, mean that many patients are managed by non‑specialist physicians. Artificial intelligence (AI) models...

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