Clinical pharmacokinetics

01 15 October 2026

DOI 10.1007/s40262-026-01715-4

Clinical Pharmacokinetics of Polmacoxib (CG100649): A Tissue-Selective Dual COX-2 and Carbonic Anhydrase I/II Inhibitor

Open DOI

Marlon C. Mallillin, Md Harunur Rashid, Yasmin Abouelbaqa et al.

02 13 October 2026

DOI 10.1007/s40262-026-01713-6

Efsubaglutide Alfa: A Comprehensive Pharmacological Review

Open DOI

Haolin Zheng, Run Yan, Fan Jiang et al.

Efsubaglutide alfa (also known as supaglutide) is a long-acting glucagon-like peptide-1 receptor agonist (GLP-1RA) engineered as a GLP-1 analogue fused to a human immunoglobulin G2 (IgG2) fragment crystallisable (Fc) domain. This narrati...

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03 9 October 2026

DOI 10.1007/s40262-026-01712-7

Physiologically Based Pharmacokinetic Modeling of Elexacaftor–Tezacaftor–Ivacaftor in Adults and Pediatric People with Cystic Fibrosis: Exploring Brain Exposure and Neuropsychiatric Adverse Events

Open DOI

Clotilde Vellat, Laurent Bourguignon, Sabine Cohen et al.

04 7 October 2026

DOI 10.1007/s40262-026-01670-0

Application of Pharmacometric Modelling Towards Precise Dosing in Neonates, Infants and Toddlers: A Scoping Review

Open DOI

Ana S. Rodríguez-Báez, Nina Kreuzberger, Claire Iannizzi et al.

05 7 October 2026

DOI 10.1007/s40262-026-01703-8

Assessing the Influence of CYP3A4 Inhibitors on Voriconazole Exposure across CYP2C19 Genotypes: A Physiologically Based Pharmacokinetic Model Analysis

Open DOI

Sahithi Thotakura, Anil R. Maharaj

06 3 October 2026

DOI 10.1007/s40262-026-01690-w

Pharmacokinetics of Efavirenz in Pregnancy and Postpartum with and Without First-line Tuberculosis Drugs: Results from IMPAACT P1026s

Open DOI

Marije Van Schalkwyk, Jiajia Wang, Adrie Bekker et al.

07 30 September 2026

DOI 10.1007/s40262-026-01698-2

Understanding Pharmacokinetic Variability of Pomalidomide: A Physiologically Based Pharmacokinetic Analysis of Disease-Related Physiology, Ethnicity, Hepatic Impairment, Food Effects, Drug Interactions, and Smoking

Open DOI

Jeffry Adiwidjaja, Alan V. Boddy, Andrew J. McLachlan

08 30 September 2026

DOI 10.1007/s40262-026-01708-3

Structured Evaluation of Model-Informed Precision Dosing of Mycophenolic Acid and Tacrolimus in Pediatric Patients with Kidney Disease

Open DOI

Astrid Heida, Elisabeth A. M. Cornelissen, Rob E. Aarnoutse et al.

09 30 September 2026

DOI 10.1007/s40262-026-01710-9

The Effect of Intrinsic Factors on the Pharmacokinetics of Once-Weekly Insulin Icodec in Type 1 and Type 2 Diabetes: A Population Pharmacokinetic Analysis of Phase II and Phase III trials

Open DOI

Niels R. Kristensen, Mundot P. Haridas, Athena Philis-Tsimikas et al.

10 30 September 2026

DOI 10.1007/s40262-026-01701-w

Optimization of Cefotaxime Treatment in Intensive Care Patients: Impact of Inter- and Intra-patient Variability on Pharmacokinetics and Target Attainment

Open DOI

Anthéa Deschamps, Florence Gattacceca, Olivier Blin et al.