Cancer chemotherapy and pharmacology

01 14 October 2026

DOI 10.1007/s00280-026-04959-w

Longitudinal plasma phosphorylated neurofilament-heavy chain levels in oxaliplatin-induced peripheral neuropathy: a prospective multi-institutional exploratory study

Open DOI

Yoshiharu Motoo, Katsunori Shinozaki, Masatomo Miura et al.

02 12 October 2026

DOI 10.1007/s00280-026-04967-w

Research and development of a multi-target HER2 inhibitor (CPD 1) and its mechanism and application in combating HER2-positive breast cancer

Open DOI

Jianchao Pan, Wenqing Zhang, Xiang Yang

03 12 October 2026

DOI 10.1007/s00280-026-04964-z

Antibody–drug conjugates in lung cancer: clinical development, therapeutic advances, and emerging challenges

Open DOI

Yilin Zhao, Xiaoran Ma, Xiaozhen Liu et al.

04 9 October 2026

DOI 10.1007/s00280-026-04970-1

PROTACs in personalized and precision medicine: transforming targeted therapy with advances in selectivity and patient stratification

Open DOI

Sanket Nagmoti, Eshita Kadam, Nikhil Sakle et al.

05 9 October 2026

DOI 10.1007/s00280-026-04968-9

Risk factors for immune-related adverse events associated with pembrolizumab in patients with solid tumors

Open DOI

Farah Shkakhwa, Farah Basbous, Dalia Shakhatreh et al.

06 9 October 2026

DOI 10.1007/s00280-026-04957-y

Pharmacological targeting of xCT/system Xc− to modulate temozolomide sensitivity in glioma and glioblastoma preclinical models: a focused systematic review

Open DOI

Sufyan Elhashani, Mohamed Elkawafi, Abdalmanam El Shekhi et al.

Background: Resistance to temozolomide (TMZ) remains a major barrier in glioblastoma treatment. The cystine/glutamate antiporter system Xc−, mainly through its xCT/SLC7A11 light-chain subunit, supports cystine uptake, glutathione synthes...

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07 9 October 2026

DOI 10.1007/s00280-026-04963-0

Beyond gastric acid: pharmacologic modulation of the tumor microenvironment by vonoprazan and its drug-interaction implications for chemotherapy and immunotherapy

Open DOI

Ghassan Sonji, Nada Sonji, Afaf El Katerji

08 3 October 2026

DOI 10.1007/s00280-026-04966-x

Continuous infusion of granulocyte colony-stimulating factor is associated with an advantage in neutrophil recovery in pediatric oncologic disorders

Open DOI

Yi-Lun Wang, Tsung-Yen Chang, Shih-Hsiang Chen et al.

09 24 September 2026

DOI 10.1007/s00280-026-04962-1

Association of androgen deprivation therapy and acute kidney injury in patients with prostate cancer: a systematic review and meta-analysis of 72,980 patients

Open DOI

Iago Zang Pires, Alexandre Yamada Fujimura, Marília Oberto da Silva Gobbo et al.

Purpose Androgen deprivation therapy (ADT) has been associated with increased cardiovascular and renal risks in prostate cancer patients. We performed a systematic review and meta-analysis of the currently available evidence to evaluate ...

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10 24 September 2026

DOI 10.1007/s00280-026-04951-4

Population pharmacokinetic analysis of pirtobrutinib, a non-covalent BTK inhibitor, in patients with hematological malignancies from the Phase 1/2 BRUIN study

Open DOI

Robert Bell, Lisa M O’BRien, Eunice Yuen et al.

Purpose: This study aimed to characterize the pharmacokinetics (PK) of pirtobrutinib, a highly selective and noncovalent Bruton’s tyrosine kinase (BTK) inhibitor, in adult patients with hematological malignancies using data from the Phas...

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