Brain tumor pathology

01 10 October 2026

DOI 10.1007/s10014-026-00550-6

CDKN2A deletion associated with poor prognosis in patients with TERT promoter wild-type, IDH wild-type glioblastoma

Open DOI

Shigeru Kamimura, Yuta Mitobe, Kazuki Nakamura et al.

02 3 October 2026

DOI 10.1007/s10014-026-00551-5

Germinoma in late adulthood with extensive dissemination: a case report and literature review

Open DOI

Rindai Saito, Yosuke Kitagawa, Hirokazu Takami et al.

Central nervous system germ cell tumors (CNS GCTs) are exceptionally rare in patients aged 60 years or older. We report a 61-year-old man with progressive weight loss and endocrine dysfunction over 20 months, in whom magnetic resonance i...

Read abstract

03 30 September 2026

DOI 10.1007/s10014-026-00549-z

Dural CIC::DUX4 sarcoma presenting with intracranial hemorrhage at both initial diagnosis and recurrence: a case report and literature review

Open DOI

Shu Kimura, Shota Yamashita, Masayuki Kanamori et al.

CIC -rearranged sarcoma, a rare, undifferentiated small round cell tumor characterized by CIC gene fusions, arises in deep soft tissues of extremities and trunk, whereas an intracranial origin is rare. We report an 11-year-old girl with ...

Read abstract

04 5 September 2026

DOI 10.1007/s10014-026-00548-0

Meningioma enlargement associated with luteinizing hormone-releasing hormone agonist therapy: two cases and supporting in vitro evidence

Open DOI

Toshiya Ichinose, Masashi Kinoshita, Maki Sakaguchi et al.

Luteinizing hormone-releasing hormone (LHRH) agonists are widely used for androgen-deprivation therapy in prostate cancer. Recent reports have raised concern that LHRH may influence the biological behavior of LHRH receptor-expressing int...

Read abstract

05 20 July 2026

DOI 10.1007/s10014-026-00547-1

Ependymoma-like tumor with mesenchymal differentiation harboring ZFTA::NCOA2 fusion: a case report

Open DOI

Masanobu Kumon, Masahiro Joko, Shigeo Ohba et al.

Ependymoma-like tumor with mesenchymal differentiation (ELTMD) is a recently proposed, but not yet formally defined, entity that is not recognized in the 2021 World Health Organization (WHO) classification of central nervous system tumor...

Read abstract

06 20 July 2026

DOI 10.1007/s10014-026-00546-2

Association between PLVAP downregulation and increased lymphocyte infiltration in newly diagnosed glioblastoma treated with bevacizumab

Open DOI

Hiroaki Matsuzaki, Shukang Zhao, Yoshihiro Komohara et al.

Glioblastoma (GBM) is a highly lethal brain tumor resistant to immunotherapy such as immune checkpoint inhibitors, partly because of an immunosuppressive tumor microenvironment and blood–brain barrier (BBB) dysfunction. Although bevacizu...

Read abstract

07 15 June 2026

DOI 10.1007/s10014-026-00545-3

Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype, of the adult cerebellum: a report of 2 cases

Open DOI

Kaishi Satomi, Yukino Nikai, Kuniaki Saito et al.

The 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System, 5th Edition, defines diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (dpHGG, H3-/IDH-WT) as a molecularly distinct en...

Read abstract

08 15 June 2026

DOI 10.1007/s10014-026-00544-4

Rapid immunohistochemistry for intraoperative differentiation between high-grade gliomas and primary central nervous system lymphomas: a multicenter prospective study

Open DOI

Takahiro Ono, Hiroaki Shimizu, Yuko Hiroshima et al.

Rapid intraoperative differentiation between high-grade gliomas (HGGs) and primary central nervous system lymphomas (PCNSLs) is critical because surgical strategies and adjuvant therapies differ substantially. We conducted a multicenter ...

Read abstract

09 2 June 2026

DOI 10.1007/s10014-026-00542-6

Spinal EWSR1::CREM fused mesenchymal tumor: an extracranial CNS counterpart of intracranial mesenchymal tumor, FET::CREB‑fusion positive

Open DOI

Seung-Ho Seo, Ki-Jeong Kim, Jae-Koo Lee et al.

The occurrence of mesenchymal tumor, FET::CREB fusion-positive in the spinal compartment is exceptionally rare, with only a few previously documented cases. Here, we present a unique case of a 43-year-old man who developed a mesenchymal ...

Read abstract

10 2 June 2026

DOI 10.1007/s10014-026-00543-5

Gliosarcoma of the craniovertebral junction with loss of H3K27me3: a case report with molecular profiling

Open DOI

Tomoko Ikemoto, Hirotaka Hasegawa, Taijun Hana et al.

Gliosarcoma is a rare and aggressive variant of glioblastoma characterized by biphasic glial and sarcomatous components. Lesions arising from the craniovertebral junction or brainstem are extremely uncommon, and their molecular pathogene...

Read abstract