Bioscience, biotechnology, and biochemistry

01 16 October 2026

DOI 10.1093/bbb/zbag156

An eight-ketohexose stereoisomer screen identifies d -allulose as a stereoselective suppressor of AGE-related autofluorescence in Caenorhabditis elegans

Open DOI

Masashi Sato, Keiko Hirata, Hiromu Takagishi et al.

Advanced glycation end products (AGEs) accumulate with age and contribute to age-related disease. Using an autofluorescence assay in Caenorhabditis elegans, we screened all eight ketohexose stereoisomers. The response was highly stereose...

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02 15 October 2026

DOI 10.1093/bbb/zbag155

Onion’s ability to reduce feeding and weight in fat-fed obese mice: its induction by cut and incubation at room temperature

Open DOI

Yermek Rakhat, Soo Takasu, Kohei Morikawa et al.

Health benefits with onion have been widely documented. However, its effect on obesity remains elusive. Here, we show an ability of onion to reduce food intake and weight in fat-fed obese mice: it appears upon cut and 35 °C-incubation bu...

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03 12 October 2026

DOI 10.1093/bbb/zbag154

Structures and functions of enzymes involved in primary and secondary metabolite biosynthesis mediated by amino-group carrier protein

Open DOI

Makoto Nishiyama

Thermus thermophilus, an extremely thermophilic bacterium, synthesizes lysine through a novel type of 2-aminoadipate (AAA) pathway. The pathway starts from the synthesis of homocitrate using 2-oxoglutarate and acetyl-CoA. Homocitrate is ...

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04 10 October 2026

DOI 10.1093/bbb/zbag153

Raspberry Ketone as a Contributor to the Sweet, Fruity Flavor of Heated Tobacco ( Nicotiana tabacum L.) Leaves and Insights into Its Occurrence Form

Open DOI

Toru Kishimoto, Yuka Koizumi, Kei Bando et al.

Raspberry ketone was identified as a contributor to the sweet, fruity flavor of heated Taoerxing Pushan Yezi (TPY) tobacco (Nicotiana tabacum L.) leaves through comparisons with an authentic standard, exploratory gas chromatography-olfac...

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05 8 October 2026

DOI 10.1093/bbb/zbag152

Daidzein treatment exerts antioxidant effect via SIRT3–FOXO3a axis activation

Open DOI

Takakazu Mitani, Miu Iwasaki

Metabolic dysfunction-associated progression of steatotic liver disease is closely associated with lipotoxicity-induced oxidative stress and inflammation. This study investigated whether daidzein, a major soy isoflavone, protects hepatoc...

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06 6 October 2026

DOI 10.1093/bbb/zbag151

Saccharomyces cerevisiae PA YEAST SC-1 induces IL‑12p70 production in primary human dendritic cells

Open DOI

Papawee Saiki, Saori Yamamoto, Tomoki Abe et al.

A food-grade Saccharomyces cerevisiae extract (PA YEAST SC-1) was evaluated in human dendritic cells. SC‑1 increased interleukin (IL)‑12p40 and IL‑6 expression and induced IL‑12p40, IL‑6, and IL‑12p70 secretion. In contrast, LPS did not ...

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07 5 October 2026

DOI 10.1093/bbb/zbag149

Magnetic decantation-enabled pot- and time-economical liquid-phase peptide synthesis

Open DOI

Jun Karasawa, Tatsuya Sudo, Shohei Yamashita et al.

Soluble support (tag)-assisted liquid-phase peptide synthesis (LPPS) is a greener alternative to solid-phase peptide synthesis (SPPS) because it reduces the consumption of reagents and solvents throughout the synthetic process. In conven...

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08 5 October 2026

DOI 10.1093/bbb/zbag147

Phylogeny-guided identification of a 1-kestose-degrading GH32 from fish-derived Clostridium butyricum LZK-08, with exploratory survival observations during natural infectious hematopoietic necrosis exposure in rainbow trout

Open DOI

Tadashi Fujii, Kosuke Tomiyama, Shinji Takada et al.

Dietary 1-kestose in rainbow trout was associated with higher Clostridiaceae abundance and descriptively higher survival during natural infectious hematopoietic necrosis exposure. To explore a possible microbial basis, we examined GH32 e...

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09 5 October 2026

DOI 10.1093/bbb/zbag148

Physical properties of retrogradation of rice gels produced by high shear during refrigerated storage

Open DOI

Kazumi Ninomiya, Kanta Katagiri, Mai Yamamura et al.

Rice gel (RG) is produced by applying high shear to cooked high-amylose rice, whereas rice flour gel (RFG) is prepared by gelatinizing a mixture of rice flour and water. Both gels harden during refrigerated storage because of starch retr...

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10 5 October 2026

DOI 10.1093/bbb/zbag150

Studies on transglutaminases regulating cell fates and tissue formation

Open DOI

Kiyotaka Hitomi

Transglutaminase is an enzyme that catalyzes the cross-linking reaction of proteins via glutamine- and lysine residues. In mammals, eight isozymes are distributed in various tissues and play distinct roles by modifying their preferred su...

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