Bioprocess and biosystems engineering

01 16 October 2026

DOI 10.1007/s00449-026-03444-1

Integrated dual carbon source and TCA intermediate supplementation in fed-batch fermentation of CHO cells for reduced lactate and ammonia accumulation and improved IgG1 monoclonal antibody titre

Open DOI

Ashwin Naidu, Krutika Padhye, Prajakta Dandekar et al.

02 14 October 2026

DOI 10.1007/s00449-026-03438-z

Tailoring high-cell-density fed-batch fermentation strategies to produce Russell’s viper venom-specific single-domain antibody in E. coli

Open DOI

Shivani Chauhan, Nimisha Chaudhary, Mohini Talwar et al.

Attributes of camelid-derived single-domain antibodies (sdAbs), such as enhanced antigen specificity, improved solubility and stability, efficient tissue penetration, and superior biodistribution, make them preferable therapeutics for di...

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03 14 October 2026

DOI 10.1007/s00449-026-03434-3

Construction of an industrial host for the efficient active expression of protein glutaminase (PG) in Bacillus licheniformis

Open DOI

Cuixia Zhou, Zhenyu Zhang, Kefen Wang et al.

Protein glutaminase (PG), a specific deaminase derived from C. proteolyticum, has been shown to hold significant potential for improving plant protein functionality. However, its industrial application is hindered by low expression level...

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04 12 October 2026

DOI 10.1007/s00449-026-03442-3

Impact of basal media and feeds on CHO cell cultures: a full factorial experiment implicating tryptophan in medium–feed antagonism

Open DOI

Daria Kalkova, Polina Maximova, Anna Kolokhina et al.

05 12 October 2026

DOI 10.1007/s00449-026-03443-2

High-efficiency secretion expression of FAD-dependent glucose dehydrogenase in Pichia pastoris via signal peptide optimization and redox cofactor enhancement

Open DOI

Chun Wei, Zhenao Zhang, Jiahao Xu et al.

06 12 October 2026

DOI 10.1007/s00449-026-03440-5

Fundamental aspects of lignocellulosic material as slow-release electron donor for biological sulfate reduction

Open DOI

Raul Natale, Rachel B. Costa, Tiago P. Delforno et al.

Biological sulfate reduction combined with chemical precipitation of metal sulfides is an good alternative to mitigate environmental impacts of acid mine drainage (AMD) and to recover base metals. This process requires a consistent suppl...

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07 12 October 2026

DOI 10.1007/s00449-026-03439-y

Fed-batch bioreactor intensifies degradation and detoxification of anthraquinone dyes by an immobilized white-rot fungal consortium

Open DOI

Pragnya Paramita Sahoo, Sangeeta Raut, Aswinee Kumar Panda et al.

08 12 October 2026

DOI 10.1007/s00449-026-03441-4

A three-step serum-free protocol for the robust generation of monocyte-derived dendritic cells from human hematopoietic stem/progenitor cells

Open DOI

Tsung-Yu Tseng, Hsing-Fen Tsai, Yun Chen et al.

09 12 October 2026

DOI 10.1007/s00449-026-03432-5

Community succession and functional trait reorganization in a continuous aerobic denitrification reactor under repeated hydraulic retention time reductions

Open DOI

Zhuzhong Yin, Zhaoyue Yang, Chenxiang Sun et al.

10 6 October 2026

DOI 10.1007/s00449-026-03436-1

Optimization of hyaluronic acid production through co-culture of mutant Streptococcus zooepidemicus and Streptococcus pyogenes under controlled uv and environmental conditions

Open DOI

Hilal Gi̇rGi̇n Öz, Hamdi Öğüt