Biofabrication

01 19 October 2026

DOI 10.1088/1758-5090/aeb62e

Versatile polyacrylamide/gum hybrid hydrogels for tunable mechanics and high-fidelity 3D extrusion printing

Open DOI

Mehwish Yousaf, Hazal Kutluk, Leon Balters et al.

Polyacrylamide (PAM) hydrogels are widely used in biological research for their well-established and tunable mechanical properties, which can closely match native tissue stiffness, making them attractive for mechanobiology, biosensing an...

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02 19 October 2026

DOI 10.1088/1758-5090/aeb62d

Granular hydrogel bioink for macroporous pancreatic spheroid scaffolds

Open DOI

Theresa Seah, Jingyi Zhang, Juin Ting Chen et al.

Cells positioned more than several hundred microns away from a vascular network experience insufficient oxygen and nutrient supply due to diffusion limitations, leading to compromised viability and impaired function. This challenge is es...

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03 16 October 2026

DOI 10.1088/1758-5090/aeadd2

Structural and functional remodeling of large-scale cardiac tubes

Open DOI

Sára Szádocka, Jana Teske, Annika Franke et al.

The functionality of tissue-engineered cardiac constructs using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is challenged by the cells’ immature state. To promote cell and tissue maturation, co-culture approach...

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04 16 October 2026

DOI 10.1088/1758-5090/aeadd1

3D printed graphene oxide/calcium alginate/strontium-doped hydroxyapatite composite scaffolds with enhanced osteogenic and angiogenic properties for critical-size bone defect repair

Open DOI

Ma Chunquan, Wu Xudong, A Ze Lalai Di Li et al.

The repair of critical-sized bone defects is hindered by insufficient vascularization, an unfavorable osteogenic microenvironment, and the limitations of conventional materials. Systematic studies on ternary composites of graphene oxide ...

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05 13 October 2026

DOI 10.1088/1758-5090/aeae75

Airflow controlled droplet bioprinting enables high-throughput generation of iPSC-derived thymic organoids with in vivo T cell functionality

Open DOI

Miranda Poklar, Erin Parlow, Ravikumar K et al.

The thymus is a critical organ for T cell generation. It is composed of distinct layers of thymic epithelial cells (TECs) that coordinate a complex process of antigen recognition and self-tolerance checks that result in mature population...

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06 13 October 2026

DOI 10.1088/1758-5090/aea7dc

Optogenetic-enabled biomanufacturing of long-projecting motor tracts for neural reconstruction

Open DOI

Justin C Burrell, Vishal J Tien, Phuong T Vu et al.

Tissue-engineered spinal tracts (TE-STs), a subclass of micro-tissue-engineered neural networks, are designed to replace long-range axonal pathways but are limited by the slow intrinsic growth of many neuronal subtypes, particularly spin...

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07 8 October 2026

DOI 10.1088/1758-5090/aea9cf

A 3D-printed spider silk-based functional mesh for ventral hernia repair via endogenous regeneration-promoting strategies

Open DOI

Kai Deng, Changjun Liu, Xingjie Wang et al.

Ventral hernia, a prevalent condition especially in the elderly, is primarily treated with mesh implantation. However, high postoperative recurrence persists due to mismatched degradation rates of biological meshes and tissue remodeling....

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08 7 October 2026

DOI 10.1088/1758-5090/aeb162

MLATE V3: An Open-Source Multi-Tissue AI Framework for Data-Driven Optimization of 3D-Printed and Bioprinted Scaffolds

Open DOI

Saeed Rafieyan, Minoo Partovi Nasr, Elham Ansari et al.

3D (bio)printing is increasingly used for scaffold fabrication in tissue engineering; however, identifying suitable biomaterial compositions, cell types, cell densities, and printing conditions remains largely empirical, time-consuming, ...

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09 5 October 2026

DOI 10.1088/1758-5090/ae6c5d

Perspectives on the future of biofabrication: insights from the winter school for biofabrication

Open DOI

Oliver Kopinski-Grünwald, Corinna Barella, Anastasiia Budaeva et al.

Biofabrication is a multidisciplinary field that integrates diverse technologies to create three-dimensional structures composed of living cells, biomaterials, and other biological components. One of its main goals is the realization of ...

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10 1 October 2026

DOI 10.1088/1758-5090/aea7df

Stochastic fiber templating for rapid generation of perfusable microchannels via immersed microfluidic spinning method

Open DOI

Zarya Rajestari, Christopher T Clark, Quinton Smith et al.

The fabrication of biomimetic tubular architectures within hydrogel-based tissue constructs remains a major barrier to advancing scalable tissue engineering and organoid systems. Here, we present a rapid and modular strategy for engineer...

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