Bioconjugate chemistry

01 16 October 2026

DOI 10.1021/acs.bioconjchem.6c00387

An Alternative Strategy for Albumin Binding in Therapeutics. Proof-of-Concept Synthesis of Metallacarborane−Insulin Conjugates

Open DOI

Jakub Cebula, Krzysztof Fink, Waldemar Goldeman et al.

Commercialized designs of long-acting insulins often base their protracted mode of action on fatty acid acylation, which enables interaction between insulin and serum albumin. Building on that experience, we propose an alternative design...

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02 15 October 2026

DOI 10.1021/acs.bioconjchem.6c00337

A CXCR4-Targeted Dual-Acting Nanoconjugate Combines Protein-Toxin and Small-Molecule Warheads for Synergistic Cytotoxicity

Open DOI

Julian I. Mendoza, Ariana Rueda, Gemma Quijada et al.

Self-assembling multivalent protein nanoparticles with an architecture based on His-metal coordination and specific binding to cancer stem cells have emerged as promising tools for the selective delivery of microbial toxins in oncology, ...

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03 12 October 2026

DOI 10.1021/acs.bioconjchem.6c00426

Porphyrin−Peptide Bioconjugates: Photophysical Properties and Targeted Singlet Oxygen-Mediated Photooxidation of Amyloid-β

Open DOI

Cristina Parisi, Francesco Attanasio, Giuseppina Sabatino et al.

The aberrant self-assembly of amyloid β (Aβ) peptides into toxic oligomers is a central event in Alzheimer’s disease, motivating the development of molecular systems capable of modulating or degrading these species. Porphyrins and porphy...

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04 12 October 2026

DOI 10.1021/acs.bioconjchem.6c00489

A VAPG Incorporating Targeted Self-Assembling Peptides for Efficient VSMC Restoring and Imaging in Abdominal Aortic Models

Open DOI

Xiushuang Yuan, Hongyi Huang, Siqi Zhang et al.

Vascular smooth muscle cell (VSMC) dysfunction is closely associated with vascular remodeling during abdominal aortic aneurysm (AAA) progression, making VSMC repair a vital therapeutic strategy. Although peptides capable of VSMC recruitm...

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05 12 October 2026

DOI 10.1021/acs.bioconjchem.6c00313

Glycosylated Diarylmethyloxy-Triazines: Facile Synthesis and Aqueous Self-Assembly for Supramolecular Hydrogel Formation

Open DOI

Shuto Okuda, Honoka Samizo, Shintaro Sugiura et al.

Glycosylated self-assembling molecules enable the construction of nanostructures whose surfaces are decorated with saccharides under aqueous conditions, reminiscent of biological systems at both the molecular and cellular levels. Such gl...

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06 12 October 2026

DOI 10.1021/acs.bioconjchem.6c00425

Development of a Hyaluronic Acid−Retinol Conjugate for Enhanced Photostability and Transdermal Delivery

Open DOI

Chaeheon Park, Seungchan Lee, Seung Oh Jung et al.

Despite its potent anti-aging efficacy, the practical application of retinol (ROH) remains highly restricted by its poor photostability, low aqueous solubility, and concentration-dependent cytotoxicity. Herein, we report the synthesis of...

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07 9 October 2026

DOI 10.1021/acs.bioconjchem.6c00470

DBCO/Azide-Appended Thioesters Enable Proximal-Dependent Cysteine to Lysine Labeling through S → N Acyl Shift

Open DOI

N. Fathima, Anagha S. Nair, A. M. Amrutha et al.

Thioester bonds are unique reactive functional groups with distinct reactivity profiles toward thiol and amine nucleophiles in aqueous solution. Here, we designed and synthesized thioester-appended clickable handles, including DBCO and a...

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08 9 October 2026

DOI 10.1021/acs.bioconjchem.6c00437

Facile Gram-Scale Solution Phase Synthesis of a Universal Cathepsin B-Cleavable Antibody-Drug Conjugate Linker

Open DOI

Alina Ringaci, Aladin Hamoud, Yolonda L. Colson et al.

Antibody drug conjugates (ADCs) are a key therapy in the cancer treatment arsenal. Critical to the success of the ADC is the release of the drug cargo at the desired site, and thus, enzymatically or chemically responsive linkers, connect...

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09 8 October 2026

DOI 10.1021/acs.bioconjchem.6c00403

Ultrasound-Triggered Site-Specific Chemistry Redefines Precision Oncology

Open DOI

Xinxin Xie, Shuyu Xu, Haonan Wang et al.

Ultrasound-triggered site-specific molecular chemistry has emerged as a transformative strategy for cancer therapy, yet precise spatiotemporal control of their activity remains a critical bottleneck. Endogenous stimulus-responsive strate...

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10 8 October 2026

DOI 10.1021/acs.bioconjchem.6c00395

Synthesis of Polyacrylamide-Conjugated Boronic Acid Probes for Glycocalyx Labeling

Open DOI

Alexander B. Tuzikov, Eugenia M. Rapoport, Anna I. Astakhova et al.

A polyacrylamide derivative of boric acid has been proposed for staining the cellular glycocalyx. Probes differing in their boric acid residue content and type of fluorescent label were obtained by conjugating fully activated polyacrylic...

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