Biochemistry and cell biology = Biochimie et biologie cellulaire

01 28 September 2026

DOI 10.1139/bcb-2026-0118

Trefoil Factor 1 contributes to Paclitaxel and Lapatinib resistance in brain metastatic breast cancer cells

Open DOI

Sumiran Kumar Gurung, Venu Yakati, Raghu Vamsi Kondapaneni et al.

Late occurrence of breast cancer brain metastases in patients pretreated with systemic therapies is often associated with therapy resistant brain metastatic lesions. Prior studies targeting previously identified mediators of resistance h...

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02 28 September 2026

DOI 10.1139/bcb-2026-0275

Meeting Report: 3rd Codon Usage Conference: Function, Mechanism and Evolution

Open DOI

Alexander F. Palazzo

The 3rd Codon Usage Conference: Function, Mechanism and Evolution was held May 31 to June 3, 2026, at the Bibliothèque et Archives nationales du Québec in Montreal, Canada. Here, I provide summaries of the talks that were given at the me...

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03 22 September 2026

DOI 10.1139/bcb-2026-0156

Passive and active regulation of cell wall mechanical properties

Open DOI

Jordan Ferria, Heather E. McFarlane

Plant cells are turgid and exert pressure against a stiff extracellular matrix, the plant cell wall, which resists turgor pressure and prevents cell bursting due to osmotic pressure. During growth, the cell wall yields under turgor press...

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04 5 June 2026

DOI 10.1139/bcb-2026-0094

Does the beta subunit of mitochondrial trifunctional protein modulate monolysocardiolipin acylation to cardiolipin?

Open DOI

Grant Hatch

The alpha subunit of mitochondrial trifunctional protein (αTFP) catalyzes the acylation of monolysocardiolipin (MLCL) to cardiolipin (CL). We determined whether the beta subunit of mitochondrial trifunctional protein (βTFP) impacted the ...

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05 4 June 2026

DOI 10.1139/bcb-2026-0147

Distinct effects of disease-associated mutations in the proximal C-linker on negatively cooperative binding of cyclic nucleotides to the human HCN4 channel

Open DOI

Leo Ng, Joanna Xia, Filip Van Petegem et al.

The direct binding of cAMP to the hyperpolarization-activated cyclic nucleotide-gated channel form 4 (HCN4) protein contributes to autonomic modulation of heart rate. Here, we determine affinity for binding of cyclic nucleotides directly...

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06 1 January 2026

DOI 10.1139/bcb-2026-0193

Ceramide 1-phosphate binding proteins: emerging regulators of cell physiology and disease

Open DOI

Antonio Gomez-Muñoz, Asier Benito-Vicente, Kepa B. Uribe et al.

Ceramide-1-phosphate (C1P), once considered a minor metabolic intermediate, is now recognized as a relevant regulator of cell survival, inflammation, migration, oxidative stress, glucose uptake, and adipogenesis. These diverse functions ...

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07 1 January 2026

DOI 10.1139/bcb-2025-0148

Extracellular vesicle-derived heat shock proteins as biotargets in cancer

Open DOI

C.L. Lim, J.J.W. Low, M.Z.M. Zulkifli et al.

Heat shock proteins (HSPs) are essential molecular chaperones that maintain protein homeostasis and protect cells under stress. Their extracellular functions have emerged as pivotal in cancer biology. Extracellularly released HSPs are se...

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08 1 January 2026

DOI 10.1139/bcb-2026-0043

Diphenoquinone, a small-HDL neogenesis accelerator, concurrently docks with cholesterol or POPC to human ATP-binding cassette transporter ABCA1

Open DOI

Maki Tsujita, Leticia Alves da Silva, Kosuke Nakasuka et al.

High-density lipoprotein (HDL) functionality has emerged as a key determinant of residual cardiovascular risk despite advances in low-density lipoprotein-cholesterol lowering therapies. Small HDL particles, generated through ATP-binding ...

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09 1 January 2026

DOI 10.1139/bcb-2026-0136

Beyond phenylalanine to tyrosine: Mapping the comprehensive phenylalanine hydroxylase (PAH) pathway for systems biology

Open DOI

Sophia M. Khan, Madison L. Fennell, Elizabeth Kandiotis et al.

The phenylalanine hydroxylase (PAH) pathway is an enzymatic pathway focused primarily on the hydroxylation of the amino acid L-phenylalanine (Phe) to L-tyrosine (Tyr). However, the functioning of this pathway can also have significant im...

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10 1 January 2026

DOI 10.1139/bcb-2025-0457

Autologous chylous fat improves hypertrophic scars via TSG-6: association with endoplasmic reticulum stress mediated by IRE1α phosphorylation and JNK activation

Open DOI

Xingwang Deng, Hongwei Ma, Wenjing Pang et al.

Hypertrophic scars (HS) represent pathological outcomes of traumatic or surgical injuries with dysregulated wound healing. We investigated the therapeutic effects and underlying mechanism of autologous chyle fat (ALCF) in HS formation. A...

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