Impact Factor
4.55
Journal Citation Impact
Estimated influence, citation density, publishing volume, and citation integrity from the analytics table.
Citation rate
25.00
1,411 total citations
h5-index
58
h5 depth signal
Cited share
96.7%
58 of 60
Total citations
1,411
Citation footprint
Metric signal
19.60
External metric anchor
Self-citation
0.1%
2 self-citations
Citations Trend
Monthly Publications Cadence
Citing Geographic Demographics
United States
235
United Kingdom
42
Switzerland
25
Canada
22
Germany
18
Citing Fields of Research
Pharmacology & Toxicology
59
Cellular Membrane Transporters & Receptors
36
Molecular & Cellular Toxicology
31
Physiology
28
Genetics & Genomics
28
Publishing Activity & Reach
Volume, recency, access pattern, and citing-community signals from the journal analytics record.
All-time article footprint
1,378
Articles tracked across the journal lifetime
Indexed publication set
60
58 cited publications
Last 12 months
43
10.8 publications/month
Open access share
67.4%
29 OA publications in the last year
Leading citing country
United States
235 citing publications
Leading citing field
Pharmacology & Toxicology
59 citing publications
Latest tracked publication
13 October 2026
10 recent records available
Coverage & Indexing History
v16, 1976-
v16, 1976-
Active Coverage
Research Focus & Classification
Indexed Subjects
Pharmacology & Toxicology
Cellular Membrane Transporters & Receptors
Genetics & Genomics
Molecular & Cellular Toxicology
Immunology
Neurodegenerative Disorders
Diabetes
Broad Categories
Pharmacology
Toxicology
Pharmacology & Toxicology
Cellular Membrane Transporters & Receptors
Genetics & Genomics
Neurosciences
Molecular & Cellular Toxicology
Medical Ethics
MeSH Descriptors
Pharmacology
Toxicology
Latest Publications
Recent article records with DOI-first linking and condensed abstracts.
01
DOI 10.1146/annurev-pharmtox-060425-072130
Open DOI
Environmental Epigenetic Transgenerational Inheritance and Generational Toxicology
Environmental chemicals and toxicants can promote phenotypic variation or disease not only in the individual exposed but also in individuals for multiple subsequent generations. This phenomenon is termed epigenetic transgenerational inhe...
02
DOI 10.1146/annurev-pharmtox-060325-101830
Open DOI
Tobacco and Cannabis Use Disorders: Similarities, Differences and Therapeutic Approaches
Cannabis and tobacco are two of the most commonly used drugs worldwide. Both drugs can lead to a use disorder, characterized by compulsive use despite harm and mediated by neurobiological changes in reward and motivational circuitry. Co-...
03
DOI 10.1146/annurev-pharmtox-060325-102258
Open DOI
Circadian Rhythms in Drug Response: From Molecular Clocks to Precision Dosing
Circadian rhythms organize mammalian physiology across the 24-h day through molecular clocks coordinated by the central clock in the suprachiasmatic nucleus and distributed to peripheral oscillators. These clocks regulate processes centr...
04
DOI 10.1146/annurev-pharmtox-060325-031237
Open DOI
Exercise as Medicine: The Potential of Exerkines as Therapeutics
Exercise delivers a wide variety of health benefits through many mechanisms, including the release of exerkines, signaling molecules secreted by multiple tissues during physical activity. We evaluated 34 exerkines with therapeutic potent...
05
DOI 10.1146/annurev-pharmtox-052825-085837
Open DOI
Endocannabinoid Signaling and Mood Regulation
The endocannabinoid (eCB) signaling system is a local regulator of synaptic activity across brain circuits involved in the regulation of emotional behaviors. Preclinical studies predominantly show that eCB signaling dampens acute stress ...
06
DOI 10.1146/annurev-pharmtox-062124-023947
Open DOI
Small Interfering RNA in Cardiovascular Disease: A New Frontier in Precision Medicine
Despite advances in traditional lipid-lowering, antithrombotic, and antihypertensive therapies, cardiovascular disease remains the leading cause of mortality worldwide. Small interfering RNA (siRNA) therapeutics harness the endogenous RN...
07
DOI 10.1146/annurev-pharmtox-062425-044036
Open DOI
Pharmacological Individuality: The Twists and Turns of My Journey
The intent of this review is a nearly chronicle tale of my life as a physician-scientist, recounting the events, fortuitous encounters, and sites that shaped my career. Intrigued as a clinician by the large individual variation in respon...
08
DOI 10.1146/annurev-pharmtox-060225-124705
Open DOI
Placebo Pain Relief: Mechanisms and Therapeutic Opportunities
The placebo effect has accompanied medicine throughout its history and remains a powerful modulator of health and disease. While the rise of double-blind, randomized, placebo-controlled trials has positioned placebo effects primarily as ...
09
DOI 10.1146/annurev-pharmtox-090826-125709
Open DOI
Introduction to the Theme “Context Is Everything: Defining the Factors That Contribute to Variability in Drug Response”
Drug response is shaped by far more than the interaction between a drug and its molecular target. The reviews in Volume 67 of the Annual Review of Pharmacology and Toxicology examine how temporal, pharmacokinetic, genetic, physiological,...
10
DOI 10.1146/annurev-pharmtox-060425-094846
Open DOI
Nanobodies as Versatile Next-Generation Biologics
Nanobodies, also known as single-domain antibodies or variable domains of heavy-chain-only antibodies (VHHs), are the antigen-binding domains derived from heavy-chain-only antibodies that naturally occur in camelids. Since their discover...
Bibliographical & Catalog Notes
Also issued online.
Continues Annual review of pharmacology.
Vol. 17 (APRIL 1977)19890816 Notice published Printed on acid-free paper that meets the full ANSI standard for Permanent Paper