Impact Factor
4.51
Journal Citation Impact
Estimated influence, citation density, publishing volume, and citation integrity from the analytics table.
Citation rate
43.39
1,811 total citations
h5-index
53
h5 depth signal
Cited share
95.5%
42 of 44
Total citations
1,811
Citation footprint
Metric signal
32.14
External metric anchor
Self-citation
0.3%
5 self-citations
Citations Trend
Monthly Publications Cadence
Citing Geographic Demographics
United States
185
Germany
13
United Kingdom
11
Canada
9
Spain
5
Citing Fields of Research
Immunology
44
Cancer & Development
27
Oncology
21
Hematology
20
Genetics & Genomics
18
Publishing Activity & Reach
Volume, recency, access pattern, and citing-community signals from the journal analytics record.
All-time article footprint
422
Articles tracked across the journal lifetime
Indexed publication set
44
42 cited publications
Last 12 months
24
12.0 publications/month
Open access share
79.2%
19 OA publications in the last year
Leading citing country
United States
185 citing publications
Leading citing field
Immunology
44 citing publications
Latest tracked publication
16 October 2026
10 recent records available
Coverage & Indexing History
v1, 2006-
v1, 2006-
Research Focus & Classification
Indexed Subjects
Immunology
Neurodegenerative Disorders
Hematology
Genetics & Genomics
Congenital Disorders
Noncoding RNA
Cancer & Development
Broad Categories
Pathology
Hematology
Cancer & Development
Neurodegenerative Disorders
Immunology
Cancer, Autophagy & Apoptosis
Virology
MeSH Descriptors
Pathology
Latest Publications
Recent article records with DOI-first linking and condensed abstracts.
01
DOI 10.1146/annurev-pathmechdis-032025-030232
Open DOI
Amyloid-β Immunotherapy in Alzheimer's Disease: Challenges and Opportunities
Passive anti–amyloid-β immunotherapy has shifted from repeated phase 3 failure to reproducible, although modest, clinical slowing in biomarker-defined early Alzheimer's disease. We review lessons from first-generation antibodies, includi...
02
DOI 10.1146/annurev-pathmechdis-042624-121246
Open DOI
TIME to Target Sarcomas: Lessons from the Tumor Immune Microenvironment
The tumor immune microenvironment (TIME) has emerged as a crucial regulator of antitumor immune responses with important therapeutic, prognostic, and predictive implications. Despite the success of immunotherapies in select solid tumors,...
03
DOI 10.1146/annurev-pathmechdis-042624-123521
Open DOI
Mechanisms of Regulation of Fetal Hemoglobin Levels: Implications for Treatment of Sickle Cell Disease
Sickle cell disease (SCD) is caused by one of the most common single gene defects in humans and has severe clinical consequences that affect millions of individuals worldwide. It is well established that sufficient levels of fetal hemogl...
04
DOI 10.1146/annurev-pathmechdis-042524-015234
Open DOI
Noncoding RNAs in Cancer: Functions, Mechanisms, and Targeting Approaches
Ninety-eight percent of the human transcriptome lacks protein-coding potential. A small fraction of this landscape comprises housekeeping noncoding RNAs (ncRNAs) with well-defined functions, whereas the heterogeneous group of regulatory ...
05
DOI 10.1146/annurev-pathmechdis-032125-013842
Open DOI
Enhancer Hijacking in Hematological Malignancies
Cell identity is established by tightly regulated transcriptional programs. Disruption of the regulatory mechanisms governing these programs leads to aberrant behavior and, frequently, cancer. Enhancer hijacking, the process whereby a ge...
06
DOI 10.1146/annurev-pathmechdis-032025-102741
Open DOI
Ultrasensitive Protein Detection in Cancer
Circulating protein biomarkers may offer a minimally invasive way to diagnose and follow cancers, yet their clinical utility has been limited by biological and analytical constraints. Recent advances in ultrasensitive protein detection h...
07
DOI 10.1146/annurev-pathmechdis-032125-105611
Open DOI
Extrachromosomal Circular DNA in Pathobiology: Current State
With advances in sequencing technologies and molecular tools, extrachromosomal circular DNA (eccDNA), once considered a mere by-product of genomic instability, is now recognized as playing important roles in genome plasticity, gene regul...
08
DOI 10.1146/annurev-pathmechdis-042424-123909
Open DOI
Proteomics for Precision Oncology: Lessons from Liver Cancer
It is an exciting time for the field of proteomics, which has finally demonstrated the capabilities the term has long suggested. Today it is possible to deeply analyze the proteomes of up to 100 human samples at depth on a single instrum...
09
DOI 10.1146/annurev-pathmechdis-042624-113746
Open DOI
Fault Lines in the Genome: Somatic DNA Mutations in Aging and Neurodegeneration
The human genome is both fragile and resilient: prone to alteration yet protected by extensive repair mechanisms. With age, individuals accumulate genetic damage from environmental factors and cell-intrinsic processes, with effects rangi...
10
DOI 10.1146/annurev-pathmechdis-032025-035253
Open DOI
Friedreich Ataxia: From Genetics to Mechanism to Clinical Features
Friedreich ataxia is a slowly progressive neurodegenerative disorder caused by GAA expansions in the FXN gene that lead to decreased transcription of the mRNA coding for frataxin protein. Such deficiency leads to impaired iron sulfur clu...
Bibliographical & Catalog Notes
"Mechanisms of disease."
Also issued online.