Impact Factor
3.70
Journal Citation Impact
Estimated influence, citation density, publishing volume, and citation integrity from the analytics table.
Citation rate
3.49
789 total citations
h5-index
40
h5 depth signal
Cited share
81.9%
194 of 237
Total citations
789
Citation footprint
Metric signal
3.75
External metric anchor
Self-citation
1.8%
14 self-citations
Citations Trend
Monthly Publications Cadence
Citing Geographic Demographics
United States
925
China
155
Canada
105
Japan
93
Australia
84
Citing Fields of Research
Digestive Disorders
358
Inflammatory Bowel Diseases & Infections
285
Liver Diseases
284
Gut-Brain Axis Disorders
236
Epithelial Barriers
218
Publishing Activity & Reach
Volume, recency, access pattern, and citing-community signals from the journal analytics record.
All-time article footprint
11,212
Articles tracked across the journal lifetime
Indexed publication set
237
194 cited publications
Last 12 months
128
10.7 publications/month
Open access share
23.4%
30 OA publications in the last year
Leading citing country
United States
925 citing publications
Leading citing field
Digestive Disorders
358 citing publications
Latest tracked publication
1 November 2026
10 recent records available
Coverage & Indexing History
v278n1, Jan. 2000-
v278n1, Jan. 2000-
Active Coverage
Research Focus & Classification
Indexed Subjects
Inflammatory Bowel Diseases & Infections
Digestive Disorders
Epithelial Barriers
Liver Diseases
Gut-Brain Axis Disorders
Immunology
Issuing & Sponsoring Bodies
Contributor
American Physiological Society (1887- )
Broad Categories
Gastroenterology
Physiology
Digestive Disorders
Inflammatory Bowel Diseases & Infections
Gut-Brain Axis Disorders
Hepatitis
Epithelial Barriers
MeSH Descriptors
Digestive System Physiological Phenomena
Liver
Latest Publications
Recent article records with DOI-first linking and condensed abstracts.
01
DOI 10.1152/ajpgi.00167.2026
Open DOI
The neogenin-hemojuvelin axis in murine liver is crucial for hepcidin expression
Hepcidin expression in hepatocytes relies on a multiprotein plasma membrane complex. This study establishes a critical functional axis between neogenin and hemojuvelin within this complex, revealing how their coordination is essential fo...
02
DOI 10.1152/ajpgi.90057.2026
Open DOI
Longitudinal Shifts in Gut Microbiota After Cholecystectomy: A Point of No Return in Losing Lactobacillus Spp
Cholecystectomy alters bile acid dynamics and may influence gut microbiota composition. However, longitudinal data with preoperative baseline assessment remain limited, and existing evidence is largely based on cross-sectional studies wi...
03
DOI 10.1152/ajpgi.00117.2026
Open DOI
Sex- and hepatocyte PPARγ-dependent effects of an obesogenic dietary approach to induce MASH with fibrosis in mice
Mouse models of metabolic dysfunction-associated steatotic liver disease (MASLD) are valuable tools for identifying novel molecular mechanisms that drive progression from MASLD to metabolic dysfunction-associated steatohepatitis (MASH). ...
04
DOI 10.1152/ajpgi.00157.2026
Open DOI
Reversal of injury-induced fibrosis and anal sphincter muscle dysfunction by sFRP2 in rabbits
This study demonstrates for the first time that local administration of sFRP2 into fully established external anal sphincter (EAS) fibrosis reverses fibrosis and restores anal canal pressure in a rabbit model. Through coordinated modulat...
05
DOI 10.1152/ajpgi.00316.2025
Open DOI
Soluble adenylyl cyclase regulates tight junctions of human intestinal epithelial cells via claudin-4
It is established that cAMP modulates tight junctions, but little is known about the mechanism behind. Here, for the first time, soluble adenylyl cyclase (sAC) was found to exert exclusive control over the ionic paracellular permeability...
06
DOI 10.1152/ajpgi.00223.2026
Open DOI
Ethanol reshapes FFC-driven steatohepatitis through time-dependent fibrosis and lipid-droplet remodeling
This study presents a refined murine MetALD model designed to distinguish ethanol-modified features from FFC-driven metabolic steatohepatitis. Chronic ethanol did not uniformly worsen liver injury. Instead, it selectively modified diseas...
07
DOI 10.1152/ajpgi.00133.2026
Open DOI
Three-dimensional architecture of the liver: structural organization, methodological advances, and functional implications
Though comprising only 2%–3% of body weight, the liver performs more than 500 distinct biochemical tasks, despite a parenchyma built almost entirely of hepatocytes—a single cell type that alone metabolizes carbohydrates, lipids, and prot...
08
DOI 10.1152/ajpgi.00121.2026
Open DOI
Colonic metabolomic and transcriptomic alterations in a mouse model of metabolic syndrome
This study identifies the colon as a metabolically active tissue affected in metabolic syndrome. Despite the absence of intestinal inflammation, MS NASH mice displayed altered colonic metabolism and microbiota composition, with conserved...
09
DOI 10.1152/ajpgi.00014.2026
Open DOI
Butyrate Triggers Neuronal Signaling via Release of Colonic Serotonin in a Microfluidic Model of Gut-Brain Axis
Host-microbiota interactions play a central role in regulating gastrointestinal and cardiometabolic physiology, yet the mechanistic pathways linking microbial metabolites to sensory neuronal activation remain poorly defined. In particula...
10
DOI 10.1152/ajpgi.90031.2026
Open DOI
Endoscopic gastric pacing: A minimally invasive approach for slow wave entrainment in rhythmic and dysrhythmic states
Background: Disordered gastric electrical rhythms contribute to debilitating motility disorders and existing therapies remain largely symptomatic without restoring coordinated activity. Electrical pacing has shown promise but currently r...
Bibliographical & Catalog Notes
Description based on: Vol. 41, no. 1 (Jan. 2000); title from cover.
Print issues ceased with v. 301, no. 6 (2011).
Vols. for <2000-> also carry the numbering of the consolidated version of The American journal of physiology; i.e., v. <41-> also numbered as v. <278->.
Also issued online.
Also issued as a section of the consolidated version of The American journal of physiology.