Aging cell

01 19 October 2026

DOI 10.1111/acel.70709

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine

Open DOI

Pranay Ramteke, Bahiyah Watson, Sanjana Jagannath et al.

Aging is a critical risk factor for intervertebral disc degeneration, a major contributor to chronic low back pain. Loss‐of‐function studies showed that SIRT6, a nuclear NAD + ‐dependent deacetylase, maintains disc health. We therefore i...

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02 18 October 2026

DOI 10.1111/acel.70775

Systemic Loss of Chromosome Y Associates With Age‐Related Ophthalmic Diseases in Middle‐Aged Men: A Longitudinal Multi‐Omic Study

Open DOI

Tianhao Chen, Zhaoyu Xiang, Zhe Zhang et al.

Maintaining health during global population aging represents a critical challenge, where mosaic loss of chromosome Y (LOY) in the hematopoietic system surfaces as a prevalent somatic mutation in aging men. However, its longitudinal impac...

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03 16 October 2026

DOI 10.1111/acel.70766

Senescent Fibroblasts Impair B Cell Proliferation via Cell–Cell Contact

Open DOI

Kassandra Vezyrgianni, Elizabeth MacLeod, Abigail Nutley et al.

Ageing profoundly impairs vaccine efficacy, leaving older individuals highly susceptible to infectious diseases despite vaccination. Although B cells retain the intrinsic capacity to generate germinal centre (GC) responses in older peopl...

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04 16 October 2026

DOI 10.1111/acel.70774

MTR4 : A Conserved Youth Factor for Vascular Endothelium

Open DOI

Zhenyuan Guo, Zhiqiang Chen, Jiaqi Sun et al.

Vascular endothelial cell (VEC) senescence drives organismal aging and age‐related pathologies, yet the intrinsic factors preserving endothelial youthfulness remain poorly defined. Here, we identify MTR4, an evolutionarily conserved RNA ...

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05 16 October 2026

DOI 10.1111/acel.70769

High‐Fat Diet–Induced Metabolic Stress Durably Reprograms the Liver Regenerative Compartment Toward a Senescence‐Like State

Open DOI

Mirai Yamazaki, Hiroya Yamada, Eiji Munetsuna et al.

Chronic metabolic stress is increasingly recognized as a driver of aging‐like tissue dysfunction, but whether it durably reprograms liver regenerative cells, potentially compromising tissue maintenance and repair, remains unknown. Here, ...

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06 15 October 2026

DOI 10.1111/acel.70765

METTL14 ‐Mediated m 6 A Methylation Preserves Cardiomyocyte Homeostasis and Attenuates Progeria‐Associated Cardiac Remodeling

Open DOI

Shixiao Wang, Jie Zhang, Ying Ao et al.

Hutchinson–Gilford progeria syndrome (HGPS) is a rare premature aging disorder most commonly caused by a de novo synonymous mutation (c.1824C>T) in the LMNA gene. This mutation activates aberrant splicing of prelamin A, leading to the pr...

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07 15 October 2026

DOI 10.1111/acel.70771

Mitochondrial Genetic Background Shapes Baseline Retinal Function, Age‐Related Bioenergetic Remodeling, and Microglial STING Phenotypes

Open DOI

McKenna M. Somerville, Sydney S. Lin, Scott W. Ballinger et al.

Mitochondria are central regulators of retinal bioenergetics and innate immune signaling, yet how mitochondrial genetic background and aging jointly influence immunometabolic responses in the retina remains poorly defined. Here, we inves...

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08 15 October 2026

DOI 10.1111/acel.70773

Skeletal Muscle‐Derived Extracellular Vesicles in Interorgan Communication During Aging

Open DOI

Weiyi Jiang, Kenon Chua, Joe Young et al.

Skeletal muscle is increasingly recognized as a secretory organ that communicates with distant tissues through the release of bioactive factors, including extracellular vesicles (EVs). During aging, muscle‐derived EVs have emerged as imp...

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09 14 October 2026

DOI 10.1111/acel.70761

A Hypertrophic Stimulus Drives Age‐Dependent Transcript Isoform Switching With and Without Differential Gene Expression in Skeletal Muscle

Open DOI

Pieter J. Koopmans, Abbey L. Stokes, Christopher E. Nelson et al.

Aged skeletal muscle has a reduced ability to adapt to hypertrophic stimuli concomitant with dysregulation across several molecular layers. Whether altered RNA splicing associates with impaired adaptive potential is not well studied. We ...

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10 13 October 2026

DOI 10.1111/acel.70714

The Human Ovary Exhibits Dynamic Molecular Remodeling in the Decades Post‐Menopause

Open DOI

Mark A. Watson, Bikem Soygur, Christina D. King et al.

The human ovary is among the first organs to show age‐related functional decline, resulting in menopause. Beyond this transition, the postmenopausal ovary is often regarded as quiescent and remains poorly characterized. We analyzed the p...

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