Acta neuropathologica

01 14 October 2026

DOI 10.1007/s00401-026-03106-2

MGMT expression in pediatric H3 G34-mutant diffuse hemispheric glioma: technical covariates should be addressed before clinical use

Open DOI

Fang Shen, Hansong Sheng

02 14 October 2026

DOI 10.1007/s00401-026-03105-3

The association between MGMT expression and outcome in H3 G34-mutant diffuse hemispheric glioma is robust to adjustment for pre-analytic and technical variables

Open DOI

Qunyu Zhang, Dana Tlais, Tong Lin et al.

03 13 October 2026

DOI 10.1007/s00401-026-03093-4

CHCHD2 mitigates age-associated proteostatic collapse by maintaining homeostasis of the mitochondria-lysosome axis

Open DOI

Teresa R. Kee, Brianna M. Masters, Khoi D. Tran et al.

Mutations in coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), including the Parkinson’s disease (PD)-linked CHCHD2 T61I mutation, are associated with Lewy body disorders (LBDs) by unknown mechanisms. Here, we demonstrate...

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04 13 October 2026

DOI 10.1007/s00401-026-03102-6

Pericyte loss and endothelial activation define distinct vascular states in cerebral small vessel disease

Open DOI

A. Chagnot, D. Jaime Garcia, C. McQuaid et al.

Cerebral small vessel disease (cSVD) is a leading cause of stroke and vascular cognitive impairment, yet the cellular mechanisms underlying microvascular dysfunction in human disease remain incompletely understood. In particular, the rel...

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05 13 October 2026

DOI 10.1007/s00401-026-03098-z

Chromosome 6q mediated loss of LATS1 tumour suppression as a targetable mechanism of ultra-high-risk posterior fossa A ependymoma

Open DOI

Andrew M. Donson, Andrea M. Griesinger, Rebecca J. Chapman et al.

Posterior Fossa A (PFA) is the most frequent and clinically aggressive ependymoma (EPN) subgroup, with relapse typically representing a terminal event despite intensive multimodal therapy. Ultra-high-risk PFA EPNs are characterised by ch...

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06 13 October 2026

DOI 10.1007/s00401-026-03100-8

Incident versus prevalent progressive supranuclear palsy: analyses of U.S. Alzheimer’s Disease Research Centers data indicate clinical and neuropathological features of a relatively common and underrecognized tauopathy in the aging brain

Open DOI

Benjamin J. Cushing, Ryan K. Shahidehpour, Erin L. Abner et al.

07 9 October 2026

DOI 10.1007/s00401-026-03097-0

Histone neutralization protects the ischemic brain against the consequences of stroke-associated pneumonia

Open DOI

Dongpei Yin, Anran Li, Ayan Mohamud Yusuf et al.

Bacterial pneumonia aggravates ischemic stroke via mechanisms that still remain to be determined. In ischemic stroke patients, we show that stroke-associated pneumonia is associated with poor clinical outcome and long-term neutrophil der...

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08 9 October 2026

DOI 10.1007/s00401-026-03095-2

Global and regional amyloid-β in explaining APOE-ε4 and sex associations with medial temporal tau: a neuropathology study

Open DOI

Gemma Salvadó, Colin Groot, Laura E. Wisse et al.

The medial temporal lobe (MTL) is a key region in Alzheimer’s disease (AD) pathogenesis, affected early by tau pathology. While female sex and APOE-ε4 are two known risk factors that affect tau levels, whether these factors drive tau in ...

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09 9 October 2026

DOI 10.1007/s00401-026-03071-w

Multiple motor proteins regulate TDP-43 anterograde axonal transport

Open DOI

Monica Feole, Victorio M. Pozo Devoto, Neda Dragišić et al.

10 9 October 2026

DOI 10.1007/s00401-026-03072-9

Lateral sclerosis in amyotrophic lateral sclerosis is an upper motor neuron distal axonopathy (“dying back”): a clinical-neuropathological study

Open DOI

Jianguo Liu, Kailee Ong, Alex Meng et al.

The hallmark neuropathological feature of upper motor neuron (UMN) degeneration in amyotrophic lateral sclerosis (ALS) is the “sclerosis” of the lateral corticospinal tract (CST)—the major axonal pathway connecting UMNs to lower motor ne...

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