ACS infectious diseases

01 17 October 2026

DOI 10.1021/acsinfecdis.6c00689

Targeting Force-Regulated FimH Adhesin: Assays, Mannosides, and Biologics for Anti-Virulence Therapy of UPEC Infection

Open DOI

Mohor Mitra, Zhilei Chen

Urinary tract infections (UTIs) are among the most common bacterial infections, and recurrent UTIs caused by uropathogenic Escherichia coli (UPEC) drive antibiotic use and antimicrobial resistance. FimH, the mannose-binding adhesin at th...

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02 16 October 2026

DOI 10.1021/acsinfecdis.6c00559

ATR-FTIR Spectroscopy Combined with Machine Learning Enables Detection of Schistosomiasis-Associated Biochemical Signatures in Human Serum

Open DOI

Victor Freire Ferreira de Aguilar, Tatyane Martins Cirilo, Douglas Carvalho Caixeta et al.

Schistosomiasis, caused by Schistosoma mansoni, remains a major public health burden in endemic regions, demanding rapid and reliable diagnostic strategies. Here, we report a label-free diagnostic platform based on attenuated total refle...

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03 15 October 2026

DOI 10.1021/acsinfecdis.6c00062

Cytoplasmic C-Terminal Domain of the MmpL11 Lipid Transporter Is Required for Interaction with Its Co-cistronic Partner MSMEG_0240 in Mycobacterium smegmatis

Open DOI

Sophie Lecher, Neetika Jaisinghani, Mary L. Previti et al.

MmpL proteins play an important role in the various mechanisms associated with mycobacterial virulence. Identification of interacting protein partners by classical in vitro methods is hampered by the low solubility of these integral memb...

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04 9 October 2026

DOI 10.1021/idv012i010_2140318

Issue Publication Information

Open DOI

05 9 October 2026

DOI 10.1021/acsinfecdis.6c00889

Honoring Prof. Gerard (Gerry) D. Wright, a Fearless Pioneer in Natural Product Antimicrobial Discovery and the Antibiotic Resistome

Open DOI

Georgina Cox, Eric Brown, Jayanta Haldar

06 9 October 2026

DOI 10.1021/acsinfecdis.6c00608

Why Computational Predictions Fall Short in Subclass B1 Metallo-β-Lactamase Inhibitor Discovery: Progress, Pitfalls, and Translational Opportunities

Open DOI

Alessandra Moraes Balieiro, Gilson Mateus Bittencourt Fernandes, Letisha Girdhari et al.

The global dissemination of subclass B1 metallo-β-lactamases (MBLs), especially New Delhi metallo-β-lactamase-1 (NDM-1), Verona integron-encoded metallo-β-lactamase-2 (VIM-2), and imipenemase-1 (IMP-1), threatens the clinical utility of ...

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07 9 October 2026

DOI 10.1021/idv012i010_2140319

Issue Editorial Masthead

Open DOI

08 9 October 2026

DOI 10.1021/acsinfecdis.5c01096

A Perspective on Biomarkers, Candidates for Surrogate End Points to Accelerate Successful Development of New Antiparasitic Agents for the Treatment of Chronic Chagas Disease

Open DOI

Tiffany Loy, María-Jesus Pinazo, Julio Alonso-Padilla et al.

Chagas disease, caused by Trypanosoma cruzi, remains a neglected tropical disease with limited therapeutic options. Although benznidazole and nifurtimox are the available antiparasitic treatments, assessing treatment efficacy in adults w...

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09 9 October 2026

DOI 10.1021/acsinfecdis.6c00766

Affinity-Based Proteome Profiling to Identify Targets of Tuberculosis Antibiotics

Open DOI

Liyan Huang, Kang Duan, Cara Adolph et al.

Drug-resistant Mycobacterium tuberculosis is an increasing global health crisis that requires the urgent development of new antibiotics. Understanding the mechanism of action of new inhibitors is an essential but challenging component of...

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10 8 October 2026

DOI 10.1021/acsinfecdis.6c00699

Beyond Catalysis: Physiology, Cellular Biology And Therapeutic Strategies for Metallo-β-Lactamase-Producing Pathogens

Open DOI

Brenda A. Warecki, Clarisa Parodi, Fernanda D. Romero et al.

Metallo-β-lactamases (MBLs) are zinc-dependent β-lactamases that threaten the clinical utility of carbapenems and other last-line β-lactams in Gram-negative pathogens. Their impact cannot be explained solely based on their catalytic effi...

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